Chemogenetic and optogenetic technologies for probing molecular and cellular networks

Alice Y. Ting

Professor of Genetics, Biology, and by courtesy, Chemistry, Stanford University, and Chan Zuckerberg Biohub Investigator

Alice Y. Ting and her lab are credited with developing several influential techniques, some of which have been broadly adopted by academic and industrial researchers across the world. These techniques include Proximity labeling, monovalent streptavidin, site-specific biotinylation in mammalian cells, small monovalent quantum dots for single molecule imaging, APEX2 as a genetic tag for electron microscopy, split horseradish peroxidase for visualization of synapses in vivo, FLARE for gaining genetic access to activated neural ensembles, SPARK for transcriptional readout of protein-protein interactions, and PRIME (PRobe Incorporation Mediated by Enzymes).