Boston Convention & Exhibition Center
#cellbio2023
Minisymposia
Scientific sessions known as Minisymposia offer the most groundbreaking research representing each of the seven scientific meeting tracks at Cell Bio 2023. Top-scoring abstracts within each scientific track are scheduled into Minisymposium sessions. There are 28 total scientific Minisymposia and one Education Minisymposium.
The Minisymposia for this meeting, including speaker information, can be found below.
Sunday, December 3, 3:30 pm to 5:00 pm
The actin cytoskeleton is a fundamental element of the cell. Emerging work also now reveals its extensive crosstalk with other essential cellular components, critically affecting their function, which will be the focus of this session.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration; and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Rafael Garcia-Mata, University of Toledo; and Antonis Kourtidis, Medical University of South Carolina
3:30 pm M1 Calmin, a novel ER-actin tether on ER tubules that influences cell migration. H. Merta1, T. Isogai2, G. Danuser2, W. M. Henne1; 1Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, 2Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
3:45 pm M2 Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development. W. Deng1, R. L. Carr2, R. R. Kaul2, M. Pavlova3, A. Haage4, P. Roca-Cusachs3, G. Tanentzapf1; 1Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, CANADA, 2School of Biomedical Engineering, University of British Columbia, Vancouver, BC, CANADA, 3Institute for Bioengineering of Catalonia, University of Barcelona, Barcelona, SPAIN, 4Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND.
4:00 pm M3 Functionally distinct actin filament nanoscale layers control focal adhesion assembly and microtubule-dependent disassembly. R. Kumari1, K. Ven1, M. Chastney2, J. Peränen1, J. Aaron3, L. Almeida- Souza1, E. Kremneva1, R. Poincloux4, T. Chew3, P. W. Gunning5, J. Ivaska2, P. Lappalainen1; 1University of Helsinki, Helsinki, FINLAND, 2University of Turku, Turku, FINLAND, 3HHMI Janelia, Ashburn, VA, 4Université de Toulouse, Toulouse, FRANCE, 5School of Medical Sciences, UNSW, Sydney, AUSTRALIA.
4:15 pm M4 Calcium influx mediated by a mechanosensitive ion channel TRPV4 controls actin architecture in lamellipodia to promote cell migration. E. Iu1, A. Bogatch1, W. Deng2, J. Humphries3, C. Yang4, M. Humphries5, G. Tanentzapf2, T. Svitkina4, S. Plotnikov1; 1University of Toronto, Toronto, ON, CANADA, 2University of British Columbia, Vancouver, BC, CANADA, 3Manchester Metropolitan University, Manchester, UNITED KINGDOM, 4University of Pennsylvania, Philadelphia, PA, 5University of Manchester, Manchester, UNITED KINGDOM.
4:30 pm M5 Mitochondria and ER-associated actin are required for mitochondrial fusion. P. Gatti1, C. Schiavon2, U. Manor3, M. Germain1; 1Medical Biology, Université du Québec à Trois-Rivières, Trois Rivieres, QC, CANADA, 2Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA, 3Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA.
4:45 pm M6 Capping Protein contributes to the balance of actin assembly among different F-actin networks in the C. elegans zygote. S. E. Yde, R. S. Kadzik, E. Munro, D. R. Kovar; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.
This session will discuss how dynamic cellular compartments adapt their spatial organization to changing cellular conditions and how proteins regulate the biogenesis, morphology, and function of the organelles in cells. These processes are critical for cellular division, differentiation, and communication.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Halil Aydin, University of Colorado Boulder; and Thomas Wollert, Institut Pasteur
3:30 pm M7 Structural Mechanism of Mitochondrial Membrane Remodeling by Human OPA1. H. Aydin; University of Colorado Boulder, Boulder, CO.
3:45 pm M8 Peroxisomes import proteins by a nuclear pore-like mechanism. M. L. Skowyra, Y. Gao, P. Feng, T. A. Rapoport; Cell Biology, Harvard Medical School / HHMI, Boston, MA.
4:00 pm M9 Lysosome related organelles contain an expansion compartment that mediates zinc transporter delivery to promote zinc homeostasis in C.elegans. A. Mendoza1, N. Dietrich2, C. Tan3, D. Herrera1, J. Kasiah1, Z. Payne1, D. Schneider1, C. Cubillas1, K. Kerry1; 1Washington University in St.Louis, Saint Louis, MO, 2Washington University in St.Louis,, Saint Louis, MO, 3California Institute of Technology, Pasadena, CA.
4:15 pm M10 Endoplasmic Reticulum moves by hitchhiking on Golgi-derived vesicles. A. Morrissey, S. Abeling, E. Wagner, J. Salogiannis; Molecular Physiology and Biophysics, University of Vermont, Larner College of Medicine, Burlington, VT.
4:30 pm M11 Mechanism of insulin granule biogenesis. J. Von Blume, M. Tian, A. Parchure; Department of Cell Biology, Yale School of Medicine, New Haven, CT.
4:45 pm M12 Understanding membrane dynamics in autophagy - biogenesis of omegasomes and autophagosomes. T. Wollert, J. Mohan, D. Campisi, S. Blanchard; Institut Pasteur, Paris, FRANCE.
This session will provide a modern perspective on how signaling and metabolism mutually control cellular fate in health and disease. Diverse model systems, organelle crosstalk, neuroscience, oncogenesis, and relationships between tissue homeostasis and external cues are highlighted.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics; and Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Lai (Linda) Chan, Cleveland Clinic; and Jerry Edward Chipuk, Icahn School of Medicine-Mount Sinai
3:30 pm M13 A Chemical Genetic Screen Implicates O-GlcNAc Transferase (OGT) in Maintaining Cellular Homeostasis through Mitochondrial Proteostatic Mechanisms. B. E. Gibbs, G. Q. Fei, X. Wang, M. Jost, S. Walker; Microbiology, Harvard Medical School, Boston, MA.
3:45 pm M14 The balance of mitochondrial biogenesis and degradation in neurons is impaired by ALS-linked mutation of the ER protein VapB. H. C. Wong, C. Stein, C. M. Drerup; Integrative Biology, University of Wisconsin–Madison, Madison, WI.
4:00 pm M15 Oncogenic BRAF Activates the ATF5-Dependent Mitochondrial Unfolded Protein Response To Restrict Mitochondrial Function and Senescence In Early Disease. J. Chipuk; Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY.
4:15 pm M16 Metabolic rewiring promotes metastatic potential in STK11-null KRAS-driven non-small cell lung adenocarcinoma. S. Prior, L. Sands, S. Lenahan, H. Sarausky, D. Seward, P. Deming; University of Vermont, Burlington, VT.
4:30 pm M17 Small amino acids that accumulate in tumors enable cancer cells to overcome lethal stresses. G. Cognet, C. Sheehan, G. Croley, L. Hu, A. Muir; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL.
4:45 pm M18 Exercise-induced senescence-like gene signature in fibro/adipogenic progenitors is impaired in diabetes muscle. Y. Saito1, N. Miura2, S. Yamamoto2, T. Sato2, K. Nagaoka1, T. Iwamoto1, M. Miyajima2, A. Kita1, T. S. Chikenji2; 1Department of Anatomy, Sapporo Medical University, Sapporo, JAPAN, 2Graduate School of Health Sciences, Hokkaido University, Sapporo, JAPAN.
The orchestration of protein localization within cells is a fundamental aspect of their regulation. Disruptions in this dynamic localization can lead to protein misfunction. In this session, we delve into the pivotal role of impaired protein dynamics in developing pathologies.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Martina Bazzaro, Masonic Cancer Center-University of Minnesota; and Julia von Blume, Yale School of Medicine
3:30 pm M19 Regulation of functional heterogeneity of insulin secretion hot spots in pancreatic beta cells. M. Fye, G. Gu, I. Kaverina; Vanderbilt University, Nashville, TN.
3:45 pm M20 Depleting the Golgi ATPase SPCA1 in human keratinocytes and organotypic epidermis reveals defective cell-cell adhesion, ER stress, and actin disorganization as drivers of Hailey-Hailey disease. J. L. Ayers1, C. L. Simpson1, A. Tiwaa1, C. J. Tam1, M. K. Sarkar2, J. E. Gudjonsson2; 1Dermatology, University of Washington, Seattle, WA, 2Dermatology, University of Michigan, Ann Arbor, MI.
4:00 pm M21 Single-cell, live-dynamic studies reveal AKT-driven drug resistance mechanism in colorectal cancer. J. Morris1,2,3, C. Wichaidit1,3, C. Thorne1,3; 1Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, 2University of Arizona, College of Medicine - Tucson, Tucson, AZ, 3University of Arizona Cancer Center, Tucson, AZ.
4:15 pm M22 1-deoxysphingolipids dysregulate the secretory pathway by altering membrane properties of the endoplasmic reticulum. Y. Tsai1, R. Varma1, R. Brea Fernandez2, I. Budin1; 1University of California, San Diego, La Jolla, CA, 2Universidade da Coruña, Coruña, SPAIN.
4:30 pm M23 Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases . A. Fitzpatrick; Columbia University, New York, NY.
4:45 pm M24 Seeding primary neurons with Alzheimer's brain-derived pathological tau results in the progressive formation of pathogenic conformations of tau linked to neuron dysfunction. R. L. Mueller1,2, N. M. Kanaan1,2,3; 1Department of Translational Neuroscience, Michigan State University, Grand Rapids, MI, 2Neuroscience Program, Michigan State University, East Lansing, MI, 3Hauenstein Neuroscience Center, Mercy Health Saint Mary's, Grand Rapids, MI.
Dynamic microtubule polymers and higher-order microtubule assemblies such as centrioles, basal bodies, and cilia play key roles in cellular organization and physiology. This session features work in different model systems on how these structures form and function.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Inna Nechipurenko, Worcester Polytechnic Institute; and Suvranta K. Tripathy, University of Michigan - Dearborn
3:30 pm M25 A Near-Micrometer-Scale Self-Assembled Platform around a Human Centriole: How Does It Form, and What to Make of It After All?. K. S. Lee, J. I. Ahn, H. Ravishankar, J. Park; National Institutes of Health, Bethesda, MD.
3:45 pm M26 ZYG-1-mediated phosphorylation of SAS-5 positively and negatively controls centriole assembly in Caenorhabditis elegans. P. Sankaralingam, K. O'Connell; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD.
4:00 pm M27 Poc1 is a triplet microtubule inner junction protein that promotes triplet microtubule integrity and interconnections to resist ciliary forces. M. D. Ruehle1, S. Li2, D. Agard2, C. G. Pearson1; 1Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of California San Fransisco, San Fransisco, CA.
4:15 pm M28 Cryo-electron tomography reveals the step-wise process of cilia assembly. H. E. Foster1, S. E. Lacey1, A. P. Nievergelt2, P. Capasso1, A. Chhatre2, A. Graziadei1, G. Pigino1; 1Human Technopole, Milan, ITALY, 2MPI-CBG, Dresden, GERMANY.
4:30 pm M29 In vitro reconstitution of the protein complex controlling ciliary tip dynamics. H. Saunders1, C. van den Berg1, R. Roepman2, A. Akhmanova1; 1Biology, Utrecht University, Utrecht, NETHERLANDS, 2Department of Human Genetics, Radboud University Medical Center, Nijmegen, NETHERLANDS.
4:45 pm M30 A genome-wide CRISPRa screen reveals a pathway for primary cilium disassembly linked to neurodevelopmental disease. S. D. Elliott, P. Ready, A. K. Ganga, D. K. Breslow; Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT.
This session focuses on cytoskeleton-dependent regulation of mechanobiology. Selected talks cover mechanisms across length (and phylogenetic) scales, highlighting new tools and approaches. Topics range from in-vitro reconstitution, development of molecular actuators to mechanistic insights into nuclear mechanotransduction and epigenetic modifications.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Stefanie Redemann, Sr., University of Virginia School of Medicine; and Vinay S Swaminathan, Lund University
3:30 pm M31 Regulating the material properties of focal adhesions through protein phase separation. X. Cheng, L. Case; Massachusetts Institute of Technology, Cambridge, MA.
3:45 pm M32 Curved crease origami at cellular scales enables hyper-extensibility of Lacrymaria olor. E. Flaum, V. Patil, M. Prakash; Bioengineering, Stanford University, Stanford, CA.
4:00 pm M33 Dynamic Microtubule Acetylation Drives Actomyosin Contractility in Directional Cell Migration. A. Deb Roy, C. Saez Gonzalez, E. Yadav, S. Lira, J. Rezek, F. Shahid, T. Inoue; Department of Cell Biology, Johns Hopkins University, BALTIMORE, MD.
4:15 pm M34 Probing mechanotransduction pathways in breast cancer metastasis through visualization and control of vinculin conformation. J. M. Szulczewski, M. Choi, G. Kreider-Letterman, S. Gulec, R. Superfine, K. Hahn; University of North Carolina-Chapel Hill, Chapel Hill, NC.
4:30 pm M35 Role of epigenetic modifications in the establishment of mechanical memory. J. Gauchoux--Bruna1, N. Elkhatib1, C. Lobry2; 1Institut Gustave Roussy, Villejuif, FRANCE, 2Institut de Recherche Saint Louis, Paris, FRANCE.
4:45 pm M36 Mechanical Control of Actin Polymerization is an Essential Regulator of Nuclear Mechanotransduction and Cell Programming. F. R. Valencia, D. Jiang, J. F. Du, S. V. Plotnikov; Cell and Systems Biology, University of Toronto, Toronto, ON, CANADA.
Sensing of extracellular cues and metabolic adjustments are critical for cellular homeostasis. This session discusses recent advances in sensing, signaling and integration with metabolism under physiological and pathological influences.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Paulo Caceres, Henry Ford Hospital; and Carsten Gram Hansen, University of Edinburgh - Institute for Regeneration and Repair
3:30 pm M37 Tuning Epidermal Growth Factor Receptor (EGFR) Spatiotemporal Organization Through Adaptor Protein Valency and Competition. M. F. Ullo, L. B. Case; Massachusetts Institute of Technology, Cambridge, MA.
3:45 pm M38 PDGFRα/β Heterodimers Have Distinct Internalization and Signaling Dynamics from PDGFR Homodimers. M. B. Campana, K. A. Fantauzzo, M. A. Rodgers, A. Neumann; Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO.
4:00 pm M39 DGS-1 and FIG-1 allow glia to detect and counter defects in ensheathed dendrite structure. K. C. Varandas1, B. Hodges1, L. Lubeck2, A. Farinas2, Y. Liang3, Y. Lu1, S. Shaham1; 1The Rockefeller University, New York, NY, 2Stanford University, Stanford, CA, 3Alexion Pharmaceuticals, Boston, MA.
4:15 pm M40 Reactivation of TORC1 by pheromone signaling during starvation. M. Bérard, L. Merlini, S. G. Martin; Department of molecular and cellular biology, University of Geneva, Geneva, SWITZERLAND.
4:30 pm M41 A Comprehensive Lipotoxicity Profile for Podocytes Reveals Distinct Cellular Susceptibilities. S. Sewerin1, D. Boone1, C. Kim1, J. L. Pablo1, A. Greka1,2,3; 1Broad Institute of MIT and Harvard, Cambridge, MA, 2Harvard Medical School, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA.
4:45 pm M42 Immune signaling subprograms invoked by macronutrients adapt antiviral defenses. T. Chang, D. Hancks, S. Chappidi; UT Southwestern Medical Center, Dallas, TX.
Sunday, December 3, 5:20 pm to 6:50 pm
Breaking of symmetry is a critical step in constructing the unique shapes of multicellular tissues. This session will explore conserved and unique concepts of tissue shape formation in several different model systems.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Richa Arya, Banaras Hindu University, India; and Edgar R. Gomes, iMM - Lisbon
5:20 pm M43 The molecular mechanism of the core planar cell polarity complex elucidated with single-molecule imaging techniques in live Drosophila wing cells. S. Nissen1,2, A. Weiner1, A. Dunn1, J. Axelrod1; 1Stanford University, Stanford, CA, 2University of Copenhagen, Copenhagen, DENMARK.
5:35 pm M44 Pre-patterning of an actomyosin network by a cell adhesion gradient to control tissue flow. N. Clarke1, J. Totz2, J. Dunkel2, A. Martin1; 1Biology, Massachusetts Institute of Technology, Cambridge, MA, 2Applied Math, Massachusetts Institute of Technology, Cambridge, MA.
5:50 pm M45 Spatial and temporal regulation of cell-cell fusion in human placenta. V. Farmer, M. Keenen, A. Gladfelter; Duke University, Durham, NC.
6:05 pm M46 Surround yourself with the finest: Organs, basement membranes, and morphogenesis. H. Ku; University of California, Berkeley, Berkeley, CA.
6:20 pm M47 A morphogenetic wave in the chick embryo lateral mesoderm generates mesenchymal-epithelial transition through a 3D-rosette intermediate. M. Abboud Asleh1, M. Zaher1, J. Asleh2, J. Jadon1, L. Shaulov1, R. Yelin1, T. Schultheiss1; 1Genetics and Developmental Biology, Technion-Israel Institute of Technology, Haifa, ISRAEL, 2Technion-Israel Institute of Technology, Haifa, ISRAEL.
6:35 pm M48 Coordination of cell cycle and morphogenesis during organ formation. J. Matthew1, V. Vishwakarma1, T. P. Le1, S. Chung2; 1Biological Sciences, Louisiana State University, BATON ROUGE, LA, 2Biological Sciences, Louisiana State University, Baton Rouge, LA.
Approaches presented will target students at varying preparation levels in a variety of environments, inside and outside of the classroom. Science literacy, summer research and mentoring programs, student perception studies, and workforce development support will be discussed.
Track(s): Education, Professional Development, Diversity and Inclusion
Co-Chairs: Kimberly Baker, University of Indianapolis; Laurie Cook, SUNY Brockport; and Melville Vaughan, University of Central Oklahoma
5:20 pm M49 Modernizing graduate and postdoctoral education to support development of a diverse biomedical workforce. C. N. Fuhrmann1, B. Natalizio1, B. Lindstaedt2; 1RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 2University of Massachusetts Chan Medical School, Worcester, MA.
5:35 pm M50 An Inclusive Summer Research Experience Promotes Minority Student Engagement in STEM. C. Carter1, A. Gooch2, C. Davis1, M. Van Stry1; 1Biology, Lane College, Jackson, TN, 2Chemistry, Lane College, Jackson, TN.
5:50 pm M51 Undergraduates’ science identity and science literacy is enhanced by a new curriculum on molecular biology preprint peer review. R. Lijek1, G. McDowell2, M. Balgopal3; 1Mount Holyoke College, South Hadley, MA, 2Lightoller, LLC, Chicago, IL, 3Colorado State University, Fort Collins, CO.
6:05 pm M52 Investigations into undergraduate biology syllabi: instructor omissions and recommendations. S. Ewell1, A. Harvey2, M. Maloney2, A. Clark3, L. Stevison2, C. Ballen2; 1University of Mississippi, Oxford, MS, 2Auburn University, Auburn, AL, 3University of Alabama at Birmingham, BIrmingham, AL.
6:20 pm M53 Differences in the perceptions of trust by undergraduate students from marginalized backgrounds and their faculty research mentors in STEM. S. W. Lee1, S. Dingwall2, R. A. Cardullo2; 1Developmental and Cell Biology, University of California, Irvine, Irvine, CA, 2University of California, Riverside, Riverside, CA.
6:35 pm M54 Developing Scholars: a Bilateral Approach to Building a Community of Researchers. J. Moore; University of Colorado Anschutz Medical Campus, Aurora, CO.
This session will focus on the molecular mechanisms determining cell fate and specialization throughout evolution.
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems
Co-Chairs: Georgia Rapti, EMBL; and Huocong Huang, UT Southwestern Medical Center
5:20 pm M55 AID governs plasma cell fate decision by co-operation with TET2 to demethylate irf4 locus in germinal center B cells. R. D'aulerio, M. He, M. M. S. Oliveira, L. S. Westerberg; Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SWEDEN.
5:35 pm M56 Single cell RNA sequencing reveals the intracellular developmental program of a highly divergent eukaryotic parasite. K. McCarty1, P. Jaroenlak2, D. Ekiert1, G. Bhabha1; 1New York University Grossman School of Medicine, New York, NY, 2Chulalongkorn University, Bangkok, THAILAND.
5:50 pm M57 Topological damping in an ultrafast giant cell. R. Chang, M. Prakash; Bioengineering, Stanford University, Stanford, CA.
6:05 pm M58 Ruptoblasts act as surveillance for hormonal dysregulation in planarian. C. Chai1, E. Sultan2, S. Sarkar1, L. Zhong1, O. Gerchoni-Yahalom2, B. Rosental2, B. Wang1; 1Bioengineering, Stanford University, Stanford, CA, 2The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev, Beer Sheva, ISRAEL.
6:20 pm M59 Learning and Memory Without a Brain. D. Rajan1, T. Makushok2, W. Marshall1; 1University of California, San Francisco, SAN FRANCISCO, CA, 2Altos Labs, Redwood City, CA.
6:35 pm M60 Single-cell RNAseq in a sponge sheds light on the origin of animal cell types. J. Musser1, L. Moroz2, D. Arendt3; 1Yale University, New Havn, CT, 2University of Florida, Gainesville, FL, 3European Molecular Biology Laboratory, Heidelberg, GERMANY.
Eukaryotic genome organization within the nucleus is fundamental for many cellular processes. The session includes a diverse range of speakers, concentrating on the latest developments in the field of genome biology.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair; and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Igor Cestari, Institute of Parasitology, McGill University; and Fei Li, Department of Biology, New York University
5:20 pm M61 Exportin-mediated docking of transcription factors to the nuclear pore complex mediates localization of chromatin to the nuclear periphery. J. Brickner, D. G. Brickner, K. Zehr, T. Ge, J. Van Belzen; Northwestern University, Evanston, IL.
5:35 pm M62 Profiling the interactions of epigenetic regulators and their control of various T cells states. M. M. Inge1, T. Siggers2; 1Cell and Molecular Biology, Boston University, Boston, MA, 2Biology, Boston University, Boston, MA.
5:50 pm M63 SUMO as a glue promotes ALT telomere maintenance via PML-dependent and independent phase separation. R. Zhao1, A. Wivagg1, A. Wondisford2, D. Chenoweth3, H. Zhang1; 1Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA, 2Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 3Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA.
6:05 pm M64 Centromere size variations: new genetic determinants of mitotic fidelity. A. SEN GUPTA, S. McKinney, D. Tsuchiya, Z. Yu, S. Smith, J. Unruh, M. Mattingly, S. Shivanandan, J. Gerton; Stowers Institute for Medical Research, Kansas City, MO.
6:20 pm M65 Coilin Mediates m6A RNA Methylation through the Regulated Expression of METTL3 and hnRNPA2B1. D. McLaurin, S. Tucker, M. Hebert; Cell & Molecular Biology, University of Mississippi Medical Center, Jackson, MS.
6:35 pm M66 PRC1 Composition and Chromatin Interaction Determine Degree of Chromatin Condensation. S. Niekamp, S. Marr, T. E. Oei, R. Subramanian, R. E. Kingston; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA.
Cells reprogram their physiology and functionality in response to external stimuli and metabolic cues. This symposium covers new mechanistic insights into the interplay between signaling pathways and metabolism in changing cell states and physiology.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Chun-Yan Lim, Guangzhou National Laboratory, China; and Alexander Muir, University of Chicago
5:20 pm M67 High throughput identification of calcium-regulated proteins across diverse proteomes. Y. Sancak; University of Washington, Seattle, WA.
5:35 pm M68 Dynamics of ATP metabolism generates two heritable stable states in yeast. P. Nanda, A. W. Murray; Molecular and Cellular Biology, Harvard University, Cambridge, MA.
5:50 pm M69 PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. N. Niemi; Washington University in St. Louis, St. Louis, MO.
6:05 pm M70 Metabolic Regulation of Cell Fate and Function in Mammalian Skin Implications for Tissue Homeostasis and Aging. M. Forni, Y. Xu, W. Krause, V. Horsley; Yale University, New haven, CT.
6:20 pm M71 Mitochondrial Chaperonin CLPB: A New Regulator of Mitochondrial Cristae Structure and Functions. A. Kadam, P. Jadiya, D. Tomar; Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
6:35 pm M72 Signal integration by a bHLH transcription factor network enables neural fate choice. N. Nandagopal1, A. Terrio2, A. Jambhekar1, G. Lahav1; 1Harvard Medical School, Boston, MA, 2Tufts Medical School, Boston, MA.
In this session, we will discuss how developing systems self-organize. We will hear about mechanisms that organize the cytoplasm and polarize the cortex during symmetry breaking and how cells form boundaries and differentiate in a temporal and spatial-dependent manner.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Katerina Ragkousi, Amherst College; and Vasundhara Sharma, Sartorius Stedim Biotech
5:20 pm M73 De novo generation of spatially organized cytoplasm. X. Cheng; University of Southern California, Los Angeles, CA.
5:35 pm M74 Centrosome-induced plasma membrane infoldings initiate growth of a cortical actin domain. R. Tam, T. J. C. Harris; University of Toronto, Toronto, ON, CANADA.
5:50 pm M75 Inducing cortical polarity by designed proteins reveals the molecular mechanism of central spindle symmetry breaking in unpolarized mammalian cells. L. K. Krüger1, J. Watson2, D. Baker2, E. Derivery1; 1MRC Laboratory of Molecular Biology, Cambridge, UNITED KINGDOM, 2Institute for Protein Design, University of Washington, Seattle, WA.
6:05 pm M76 Germ fate mediates protection of germ precursor cell division. C. Q. Connors1, M. S. Mauro1, J. T. Wiles1, S. L. Martin1, J. Dumont2, M. Shirasu-Hiza3, T. R. Davies4, J. C. Canman1; 1Department of Pathology and Cell Biology, Columbia University, New York City, NY, 2Department of Pathology and Cell Biology, Université Paris Cité, CNRS, Institut Jacques Monod, Paris, FRANCE, 3Department of Genetics and Development, Columbia University, New York City, NY, 4Department of Biosciences, Durham University, Durham, UNITED KINGDOM.
6:20 pm M77 miR-31-mediated local translation at the mitotic spindle is important for early development. J. L. Song, C. Remsburg, K. Konrad, M. Testa; Biological Sciences, University of Delaware, Newark, DE.
6:35 pm M78 Nuclear envelope buds traffic large trancripts in muscle cells. S. Zaganelli, J. Meehl, D. Petito, G. Voeltz; MCDB, University of Colorado, Boulder, CO.
This session highlights intriguing findings of the interplay and functional crosstalk between various organelles and other cellular machinery. These interactions play a vital role in regulating cell division, organelle biogenesis, subcellular transport, and intracellular viral particle assembly.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration; and Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Mi Hye Song, Oakland University; and Alexander Sorkin, University of of Pittsburgh
5:20 pm M79 Cell-cycle regulated tug-of-war between microtubule motors positions major trafficking organelles. A. V. Sawant, J. Lee, I. Kaverina; Vanderbilt University, Nashville, TN.
5:35 pm M80 Zika virus NS3 drives the assembly of a viroplasm-like structure with MTOC activity. T. Sultana, C. Zheng, R. Buchwalter, T. Megraw; Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL.
5:50 pm M81 Dysregulation of the ER blocks recruitment of centrosome associated proteins resulting in mitotic failure. K. Rollins, T. Blankenship; UNIVERSITY OF DENVER, DEPARTMENT OF BIOLOGICAL SCIENCES, Denver, CO.
6:05 pm M82 Single-molecule tracking of protein transport from the ER to lipid droplets. A. Mizrak1, J. Kæstel-Hansen2, W. Harper1, N. Hatzakis2, R. Farese Jr3, T. Walther3; 1Department of Cell Biology, Harvard Medical School, Boston, MA, 2Department of Chemistry & Nanoscience Center, University of Copenhagen, Copenhagen, DENMARK, 3Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.
6:20 pm M83 Quantitative mapping of autophagic cargo during nutrient stress reveals membrane receptors for Golgiphagy. K. Hickey1, S. Swarup2, I. Smith3, J. Paoli1, E. Miguel Whelan1, J. Paulo1, W. Harper1; 1Cell Biology, Harvard Medical School, Boston, MA, 2Casma Therapeutics, Cambridge, MA, 3Velia Therapeutics, San Diego, CA.
6:35 pm M84 Cytoplasmic ribosomes hitchhike on mitochondria to dendrites in vivo. C. Renken, S. Kim, Y. Wu, M. Hammarlund, S. Yogev; Yale University, New Haven, CT.
Cells possess intrinsic health monitoring and maintenance mechanisms that can become insufficient and dysfunctional in aging and disease, limiting the cell’s ability to deal with perturbations and compromising bioresilience. In this session, we will explore these homeostatic mechanisms.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Diego Acosta Alvear, Altos Labs; and Yasunori Saheki, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
5:20 pm M85 The differential proteostasis mechanisms in response to acute and persistent stresses. C. Zhou; Buck Institute for Research on Aging, Novato, CA.
5:35 pm M86 An obligate intracellular bacterial pathogen forms a direct, interkingdom membrane contact site. Y. Acevedo-Sánchez1, P. J. Woida1, S. Kraemer2, R. L. Lamason1; 1Biology, MIT, Cambridge, MA, 2Center for Nanoscale Systems, Harvard University, Cambridge, MA.
5:50 pm M87 Parkinson Sac domain mutation in Synaptojanin 1 affects ciliary properties in dopaminergic neurons. N. Mohd Rafiq1,2,3,4, K. Fujise1,2,3,4, M. Rosenfeld1,2,3,4, P. Xu1,2,3,4, P. De Camilli1,2,3,4; 1Departments of Neuroscience, Yale University, New Haven, CT, 2Departments of Cell Biology, Yale University, New Haven, CT, 3Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University, New Haven, CT, 4Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD.
6:05 pm M88 SQST-1/p62 and SKN-1/NRF2 promote phagocytosis under stress by promoting lysosomal trafficking. A. Elkhalil, P. Ghose; University of Texas At Arlington, Arlington, TX.
6:20 pm M89 Unconventional binding of Salmonella effector SipA to F-actin mimics the structural effects of inorganic phosphate and phalloidin. E. Niedzialkowska1, L. A. Runyan2, E. H. Egelman1, E. Kudryashova2, D. S. Kudryashov2; 1Biochemistry and Molecular Genetics, University of Virginia, Charlottesvilee, VA, 2Chemistry & Biochemistry, The Ohio State University, Columbus, OH.
6:35 pm M90 The Integrated Stress Response Unconventionally Activates the Unfolded Protein Response Sensor IRE1. F. Zappa, D. Acosta-Alvear; Bay Area Institute of Science, Altos Labs, Redwood City, CA.
Tuesday, December 5, 3:30 pm to 5:00 pm
The cellular genome contains an enormous amount of DNA information to produce a vast number of RNA and protein molecules. This mini-symposium presents up-to-date work from diverse speakers focusing on the cellular genome organization and gene regulation.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair
Co-Chairs: Junnan Fang, Emory University School of Medicine; and Yaron Shav-Tal, Bar-Ilan University
3:30 pm M91 Mechanisms of genome scaling during embryogenesis and evolution. C. Zhou; University of California, Berkeley, Berkeley, CA.
3:45 pm M92 Tackling mitotic chromosome (un-)folding. A. Brunner1, K. Sandvold Beckwith1, J. Hossain2, N. Rosalia Morero1, A. Halavatyi1, J. Ellenberg1; 1EMBL - European Molecular Biology Laboratory, Heidelberg, GERMANY, 2Centre for Cancer Immunology, University of Southampton, Southampton, UNITED KINGDOM.
4:00 pm M93 Dynamics and mechanics of R-loop formation during DNA interrogation by Cas12a from different species. K. Aris1, J. Cofsky2, H. Shi3, N. Al-Sayyad1, I. Ivanov4, A. Balaji1, J. Doudna3,5, Z. Bryant1; 1Stanford University, Stanford, CA, 2Harvard Medical School, Cambridge, MA, 3UC Berkeley, Berkeley, CA, 4Chan Zuckerberg Biohub, San Francisco, CA, 5Howard Hughes Medical Institute, UC Berkeley, CA.
4:15 pm M94 Lamins A and B1 are essential for mouse development by conferring proper 3D genome organization and cell fate in the extraembryonic endoderm. S. Debic1,2, X. Zheng1, Y. Kim3, Y. Zheng1,2; 1Carnegie Institution for Science, Department of Embryology, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Soonchunhyang Institute of Medi-Bio Science, Cheonan City, KOREA, REPUBLIC OF.
4:30 pm M95 Identifying the mechanism of olfactory receptor gene regulation in primary olfactory neurons via live-cell imaging of genomic loci and transcription factors. J. Pulupa, O. Stathi, S. Lomvardas; Columbia University, New York, NY.
4:45 pm M96 Towards a Comprehensive Characterization of Human DNA Replication Kinetics. N. Rhind; UMass Med School, Worcester, MA.
Advancements in understanding the tumor microenvironment are revealing new treatment possibilities. This session will explore how the surroundings of tumors influence their behaviour and pave the way for novel therapeutic approaches.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: David C. Michael, University of Bath; and Kuo-Hui Su, The University of Toledo
3:30 pm Co-Chair. D. C. Michael; University of Bath, Bath, UNITED KINGDOM.
4:15 pm M100 Multidimensional single-object screening of pancreatic cancer spheroids/organoids reveals cooperative vulnerabilities in mitotic and cell adhesion pathways that associate with KRAS mutations. J. A. Kelber1, A. Aquino2, A. Todd2, N. Haindl2, M. Wallace2, J. Gamez2, E. Ortiz2; 1Biology, Baylor University, Waco, TX, 2California State University, Northridge, Los Angeles, CA.
4:30 pm M101 Neoadjuvant Niraparib Therapy and Chemotherapy Reverse HRD-driven Immunosuppression of Tumor Microenvironment in Ovarian Cancer. Y. Luo1,2, Y. Xia3, D. Liu3, X. Li3, H. Li3, Y. Zhao4, D. Ma3, Y. Fang3, H. Liang1,2, Q. Gao3; 1University of Texas MD Anderson Cancer, Houston, TX, 2Baylor College of Medicine, Houston, TX, 3Tongji Medical College, Wuhan, CHINA, 4Precision Scientific (Beijing) Co., Ltd., Beijing, CHINA.
4:45 pm M102 HER2-dependent prostate cancer cells downregulate androgen receptor activity to drive resistance to therapy. S. Wilkinson, A. Ku, I. King, A. Baj, D. Low, F. Karzai, S. A. Harmon, N. T. Terrigino, J. R. Bright, S. Y. Trostel, R. Lis, B. Turkbey, W. L. Dahut, A. G. Sowalsky; National Cancer Institute, NIH, Bethesda, MD.
3:30 pm M97 Microphysiological systems to study the tumor microenvironment: from memory-like NK cells to immune exhaustion. R. Turaga, J. Ayuso, S. Zima, C. Reed-McBain; University of Wisconsin, Madison, WI.
3:45 pm M98 Nutrient stress enhances DNA repair pathways in pancreatic cancer. G. Croley1, C. Sheehan1, G. Cognet1, L. Hu1, J. Martin1, A. Thomas-Toth2, J. LaBelle2, A. Muir1; 1Ben May Department for Cancer Research, University of Chicago, Chicago, IL, 2Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL.
4:00 pm M99 Emerin modulates mechanotransduction to facilitate breast cancer metastasis. E. Hansen Miller1, J. M. Holaska1, M. Wang2; 1Biomedical Sciences, Cooper Medical School At Rowan, Camden, NJ, 2Rowan School of Osteopathic Medicine, Stratford, NJ.
Advances in technology can catalyze seminal advances in cell biology. The session will feature cutting-edge techniques in electron and light microscopy, chemistry, and bioinformatics that have been creatively applied to describe multi-component cellular processes. The selected talks will reveal the composition, structure, and dynamics of P-granules, ribosomes, sperm axoneme, circadian clock proteins, ultrafast neuronal endocytosis, and extracellular vesicles.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: C. Dave P. Dingal, The University of Texas at Dallas; and Julia Romano, Johns Hopkins University
3:30 pm M103 Visual Proteomics of C. reinhardtii using High-throughput Collaborative in situ Cryo-ET. R. Kelley1, M. Obr2, X. Zhang2, S. Khavnekar3, J. Plitzko3, A. Kotecha2; 1Thermo Fisher Scientific, US, Hillsboro, OR, 2Thermo Fisher Scientific, Netherlands, Eindhoven, NETHERLANDS, 3Max Planck Institute of Biochemistry, Martinsried, GERMANY.
3:45 pm M104 De novo protein identification in mammalian sperm using in situ cryo-electron tomography and AlphaFold2 docking. Z. Chen1, M. Shiozaki2, K. M. Haas1, W. M. Skinner3, S. Zhao2, C. Guo2, B. J. Polacco1, Z. Yu2, N. J. Krogan1, R. M. Kaake1, R. D. Vale2, D. A. Agard1; 1University of California, San Francisco, SAN FRANCISCO, CA, 2Janelia Research Campus, Ashburn, VA, 3University of California, Berkeley, Berkeley, CA.
4:00 pm M105 Live cell resolution of mRNA decapping subunit interaction dynamics within condensates. L. E. Fahim, J. E. Lee; Molecular and Cell Biology, BAYLOR COLLEGE OF MEDICINE - Houston, TX, Houston, TX.
4:15 pm M106 Novel microscopy tools reveal dynamic sub-cellular distributions of core clock components in Neurospora crassa. Z. Wang1, B. M. Bartholomai1, J. J. Loros2, J. C. Dunlap1; 1Department of Molecular and Systems Biology, Dartmouth College, Hanover, NH, 2Department of Biochemistry and Cell Biology, Dartmouth College, Hanover, NH.
4:30 pm M107 Investigating the impact of G2019S LRRK2 on ultrafast endocytosis at hippocampal presynapses. C. R. Eddings, Y. Imoto, S. Watanabe; Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.
4:45 pm M108 Defining ciliary extracellular vesicle subtypes by single-EV molecular analysis. I. Nikonorova, E. desRanleu, K. Jacobs, J. Saul, J. Walsh, J. Wang, M. Barr; Rutgers University, Piscataway, NJ.
The ability of stem cells to self-renew and differentiate into a variety of cell types is critical for embryonic development, tissue maintenance, and regeneration. This session will explore the latest advances in understanding stem cell fate across model systems.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Ernest G. Heimsath, Agilent Technologies, Inc; and Sandra Scharaw, Karolinska Institute
3:30 pm M109 Early Embryonic Cell Fate Decisions directed by Differential RNA Localisation and Translation. A. Hawdon1, J. Greaney1, N. Geoghegan2, A. Elsenhans3, C. Ferguson4, R. Parton4, H. Janovjak5, J. Polo6, J. Zenker1; 1Australian Regenerative Medicine Institute, Monash University, Clayton, AUSTRALIA, 2Walter and Eliza Institute of Medical Research, Parkville, AUSTRALIA, 3Department of Biology, University of Duisburg-Essen, Duisburg-Essen, GERMANY, 4Institute for Molecular Bioscience, University of Queensland, Brisbane, AUSTRALIA, 5Flinders Health and Medical Research Institute, Flinders University, Adelaide, AUSTRALIA, 6South Australian Immunogenomics Cancer Institute (SAIGENCI), University of Adelaide, Adelaide, AUSTRALIA.
3:45 pm M110 Non-cell autonomous competition eliminates karyotypic mosaicism in human embryonic stem cells. A. Ya1,2, D. A. Compton1,2, K. M. Godek1,2; 1Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
4:00 pm M111 The impact of dysfunctional mitochondria from astrocytes in Rett Syndrome on the human brain. D. L. Tomasello1, M. I. Barrasa1, D. Mankus2, K. I. Alarcon3, A. K. Lytton-Jean2, X. S. Liu4, R. Jaenisch1; 1Whitehead Institute for Biomedical Research, Cambridge, MA, 2Koch Institute for Integrative Cancer Research, Cambridge, MA, 3Massachusetts Institute of Technology, Cambridge, MA, 4Columbia University Medical Center, New York, NY.
4:15 pm M112 Intracellular Cell Tension Regulates Stem Cell Conversion To The Mesoderm Lineage Downstream Of The Apoptotic Pathway. L. Fort, I. G. Macara; Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
4:30 pm M113 Myosin 2A-driven planar cell division ensures lumen integrity in intestinal organoids. M. Yousafzai, K. Remmert, C. Alexander, A. Pedrosa, L. Boley, A. Gasilina, Y. Yim, X. Wu, J. A. Hammer; National Heart, Lung, and Blood Institute, Bethesda, MD.
4:45 pm M114 Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration. B. Benham-Pyle1, F. Mann Jr.2, C. Brewster2, D. Vuu2, E. Dewars3, S. Nowotarski2, C. Guerrero-Hernández2, S. Malloy2, K. Hall2, L. Maddera2, S. Chen2, J. Morrison2, S. McKinney2, B. Slaughter2, A. Perera2, A. Sánchez Alvarado2; 1Baylor College of Medicine, Houston, TX, 2Stowers Institute for Medical Research, Kansas City, MO, 3Duke University, Durham, NC.
This session will highlight some of the recent advances in cell biology, chemotaxis and directed migration, and bioengineering. It will specifically be focused on exploring and controlling mechanical and time-dependent cues that govern the behavior of cells from the sub-cellular to the community scale.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: C. Nadir Kaplan, Virginia Tech; and Matthew L. Kutys, University of California, San Francisco
3:30 pm M115 Synthetic control of dynamic pattern formation at the cortex. L. A. Sepaniac, A. Michaud, W. M. Bement; Center for Quantitative Cell Biology, University of Wisconsin–Madison, Madison, WI.
3:45 pm M116 Light-directed evolution of dynamically changing and computing proteins. V. Gligorovski, S. Rahi; EPFL, Lausanne, SWITZERLAND.
4:00 pm M117 Diffusion in the cytoplasm increases with cell size. C. Tan, F. Chang; University of California, San Francisco, San Francisco, CA.
4:15 pm M118 Confinement as a critical factor in guiding rheotactic cell behavior. P. Mistriotis, F. Amiri, A. Akinpelu, W. C. Keith, F. Hemmati; Auburn University, Auburn, AL.
4:30 pm M119 Optogenetic programming of large-scale collective cell migration. K. Suh1, R. H. Thornton2, J. E. Toettcher2, D. J. Cohen3; 1Chemical and Biological Engineering, Princeton University, Princeton, NJ, 2Molecular Biology, Princeton University, Princeton, NJ, 3Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ.
4:45 pm M120 Behavioral cartography: Mapping cellular behavior in the wild. M. Prakash; Stanford University, Stanford, CA.
Accurately segregating proteins to distinct intracellular locations is essential for cellular organization and processes. This session discusses mechanisms that sort various proteins into different cellular compartments for specific functions.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Sichen (Susan) Shao, Harvard Medical School; and Yuyu Song, Harvard Medical School
3:30 pm M121 Mechanisms Regulating Organellar Protein Localization. S. Shao, M. J. McKenna, M. Vasandani; Harvard Medical School, Boston, MA.
3:45 pm M122 Using Photoswitching FRET to define the interaction boundaries between Rab1 and secretory cargo. Y. Malis1, G. M. Hirschberg1, E. H. Sklan2, G. H. Patterson3, K. Hirschberg1; 1Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, ISRAEL, 2Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, ISRAEL, 3Section on Biophotonics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD.
4:00 pm M123 Advanced microscopy time-resolves the higher-order structure of the exocyst and it reveals an unexpected function for Sec18. O. Gallego1, M. Puig1, S. Ortiz1, P. Hoess2, S. Meek1, M. Mund2, J. Ries2, C. Manzo3; 1Universitat Pompeu Fabra, Barcelona, SPAIN, 2European Molecular Biology Laboratory, Heidelberg, GERMANY, 3Universitat de Vic, Vic, SPAIN.
4:15 pm M124 Filamentation of Lipoprotein Lipase in Secretory Vesicles. K. H. Gunn1, P. B. Rosenthal2, S. B. Neher1; 1Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, London, UNITED KINGDOM.
4:30 pm M125 A unifying mechanism underlying the trafficking of proteins to the primary cilium membrane. V. Palicharla1, M. Jiang2, J. Sun2, S. Mukhopadhyay1; 1Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 2Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.
4:45 pm M126 Transporting the Gli transcription factors to the cilium tip compartment for Hedgehog signaling: A tale of two motor systems. S. J. Surendran, P. Ku, R. Subramanian; Massachusetts General Hospital, Boston, MA.
Cell migration is a complex process requiring precise coordination of morphodynamic alterations under the regulation of diverse signaling networks. The session will delve into how several of these signaling networks regulate the movement and chemotaxis of different cell types.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration; and Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Chuan-Hsiang Bear Huang, Johns Hopkins University School of Medicine Department of Pathology; and Charlotte M. Vines, University of Texas-El Paso
3:30 pm Co-Chair. C. Huang; Johns Hopkins University School of Medicine Department of Pathology.
3:30 pm Co-Chair. C. Vines; University of Texas-El Paso.
3:30 pm M127 Secretion of exosome-associated DNA (SEAD) regulates neutrophil chemotaxis. S. B. Arya1, S. P. Collie2, C. A. Parent3; 1Life Sciences Institute, University of Michigan, Ann Arbor, MI, 2Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 3Life Sciences Institute, Department of Pharmacology and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI.
3:45 pm M128 Mechanocontrol of RhoA dynamics by Caveolae is required for directional migration. V. SINGH1, C. Viaris de Lesegno1, P. Sens2, C. Lamaze1; 1INSERM U1143 - CNRS UMR 3666, Institut Curie, PARIS, FRANCE, 2Physico-chimie Curie (UMR168), Institut Curie, PARIS, FRANCE.
4:00 pm M129 The activation of INF2 by Piezo1/Ca2+induces de-adhesion and amoeboid migration in confined environments. N. Kar, A. P. Caruso, N. Prokopiou, J. S. Logue; Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY.
4:15 pm M130 Investigating how FGF signaling guides cell migration in vivo. T. V. Gibney1, N. R. Rasmussen2, D. J. Reiner2, A. M. Pani1,3; 1Department of Biology, University of Virginia, Charlottesville, VA, 2Department of Translational Medical Science, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, 3Department of Cell Biology, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA.
4:30 pm M131 Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. J. A. Jackson1,2, M. Denk-Lobnig3, A. C. Martin1; 1Biology, Massachusetts Institute of Technology, Cambridge, MA, 2Biophysics, Harvard University, Cambridge, MA, 3Biophysics, University of Michigan Ann Arbor, Ann Arbor, MI.
4:45 pm M132 A dynamic partitioning mechanism for polarizing membrane protein distribution. T. Banerjee1,2, S. Matsuoka3, D. Biswas4, Y. Miao1, D. S. Pal1, Y. Kamimura5, M. Ueda3, P. N. Devreotes1, P. A. Iglesias4; 1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 3Laboratory of Single Molecule Biology, Graduate School of Frontier Biosciences, Osaka University, Osaka, JAPAN, 4Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 5Laboratory for Cell Signaling Dynamics, RIKEN Center for Biosystems Dynamics Research, Osaka, JAPAN.
Tuesday, December 5, 5:20 pm to 6:50 pm
Dividing cells must build specialized machinery: the spindle and kinetochore to segregate chromosomes, and the cytokinetic furrow to split the cytoplasm. This session features work on how these three machines assemble and function robustly.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Xianrui Cheng, University of Southern California; and Sophie Dumont, University of California, San Francisco
5:20 pm M133 Spatially distinct regulatory inputs modulate mitotic-phase GAP activity to locally limit RhoA activity for successful cytokinesis. F. Wolff1, E. Zanin1, S. Srinivasan1, C. Nöcker1, S. Mangal2, T. Mikeladze-Dvali2; 1Biology, Friedrich-Alexander-Universität Erlangen, Erlangen, GERMANY, 2Biology, Ludwig-Maximilians University, München, GERMANY.
5:35 pm M134 Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mediated signal is required for correct centrosome positioning in prophase, and maintenance of mitotic fidelity. J. T. Lima, J. G. Ferreira; I3S, Porto, PORTUGAL.
5:50 pm M135 Kinetochore-independent mechanisms contribute to chromosome segregation in human cells. F. Renda1, A. Alfieri1, R. Fisher1, I. Tikhonenko1, C. Miles2, A. Mogilner3, A. Khodjakov1; 1New York State Department of Health, Wadsworth Center, Albany, NY, 2Department of Mathematics, University of California, Irvine, CA, 3Courant Institute and Biology Department, New York University, New York, NY.
6:05 pm M136 Centrosome age breaks spindle symmetry even in “symmetrically” dividing cells. A. Thomas, P. Meraldi; Department of Cell Physiology and Metabolism, Faculty of Medecine, University of Geneva, Geneva, SWITZERLAND.
6:20 pm M137 Centromere stretching in oocytes is a reproductive isolating barrier in mice. W. El Yakoubi, T. Akera; Center for Scientific Review, NIH, Bethesda, MD.
6:35 pm M138 Bi-directional modulation of centromere binding via evolutionary innovation in the CENP-T histone fold domain. D. Dudka1, A. L. Nguyen2,3, K. Boese1, O. Marescal2,3, B. Akins1, B. E. Black4,5,6, I. M. Cheeseman2,3, M. A. Lampson1,5; 1Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 3Whitehead Institute for Biomedical Research, Cambridge, MA, 4Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 5Penn Center for Genome Integrity, University of Pennsylvania, Philadelphia, PA, 6Epigenetics Institute, University of Pennsylvania, Philadelphia, PA.
Communities of cells respond to biochemical and mechanical signals to build tissue form. This session will explore different mechanisms used by cells during the process of tissue morphogenesis.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids; and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Tara M. Finegan, University of Missouri; and Celeste M. Nelson, Princeton University
5:20 pm M139 PIK3CA-induces biophysical changes in the mammary epithelium that disrupt tissue architecture by altering homeostatic programs of self-organization. V. Srivastava1, J. L. Hu1, J. Le1, B. A. Moser1, R. Nakagawa1, S. Durney1, J. C. Garbe2, M. A. LaBarge3, A. Goga1, Z. J. Gartner1; 1University of California San Francisco, San Francisco, CA, 2Lawrence Berkeley National Laboratory, Berkeley, CA, 3Beckman Research Institute, City of Hope, Duarte, CA.
5:35 pm M140 Transition dynamics between distinct diffusible states regulate morphogen signaling range. G. Schlissel1, M. Meziane1,2, D. Narducci2, A. Jain1,2, A. S. Hansen2, P. Li1,2; 1Whitehead Institute, Cambridge, MA, 2Massachusetts Institute of Technology, Cambridge, MA.
5:50 pm M141 Adapting modes of cell migration to diverse tissue environments: how primordial germ cells traverse the mouse embryo. K. Goodwin, K. McDole; MRC Laboratory of Molecular Biology, Cambridge, UNITED KINGDOM.
6:05 pm M142 On form and fate: how morphogenesis patterns epithelial differentiation. K. Goodwin, K. Shelburne, C. M. Nelson; Princeton University, Princeton, NJ.
6:20 pm M143 Towards engineering control of epithelial branching in the developing mammalian kidney. L. Prahl, A. Hughes; Bioengineering, University of Pennsylvania, Philadelphia, PA.
6:35 pm M144 Tissue fluidity: a double-edged sword for multicellular patterning. R. M. Garner, A. A. Ruzette, S. E. McGeary, A. Denisenko, T. Chen, A. M. Klein, S. G. Megason; Department of Systems Biology, Harvard Medical School, Boston, MA.
This session will focus on the molecular mechanisms underlying neurogenesis, axon guidance and neuro-glia interactions in the developing brain.
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems; and Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Shen-Ju Chou, Academia Sinica; and Alessandro Didonna, East Carolina University - Greenville, NC
5:20 pm M145 Molecular mechanisms for self-assembly of circuit pioneer cells in C. elegans brain assembly. L. Sabou, M. Bhushan, F. Caroti, A. Kumar, L. Gandara, J. Crocker, G. Rapti; EMBL, Heidelberg, GERMANY.
5:35 pm M146 Combinatorial control of endoplasmic reticulum remodeling during neurogenesis via selective ER-phagy. M. Hoyer, I. Smith, J. Paoli, Y. Zhang, J. Paulo, J. Harper; Harvard Medical School, Boston, MA.
5:50 pm M147 A sensory cilium mediates specific neuron-glia attachment. L. Wexler, M. G. Heiman; Harvard Medical School, Boston, MA.
6:05 pm M148 Interphasic Somal Translocation is a prominent mode of bRG cell dissemination into the human developing neocortex. R. Wimmer; Institut Curie, Paris, FRANCE.
6:20 pm M149 Endocytosis at the axon initial segment: towards specificity and polarity regulation. K. Eichel, R. Fetter, C. Taylor, K. Shen; Stanford University, Stanford, CA.
6:35 pm M150 Non-autonomous roles of Rac1 and likely Nectin3 in axon guidance in the peripheral auditory system. S. Clancy, A. Hogan, Y. Zheng, M. Smith, E. Fateh, T. Eluvathingal Muttikkal, N. Xie, X. Lu; Cell Biology, University of Virginia School of Medicine Graduate Programs Office, Charlottesville, VA.
From the architecture of entire kinetochores and sperm flagella, to the residue-level analysis of single molecules, this session will discuss how structural and functional determinants of cellular machineries can be uncovered using multi-modal approaches in situ and in vitro.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration; and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Valentina Piano, University of Cologne; and Florian Schur, Institute of Science and Technology Austria.
5:20 pm M151 evolutionary structural comparison of sperm flagella based on high-resolution native structures. J. Zeng; Washington University in St. Louis, St. Louis, MO.
5:35 pm M152 Autoinhibited kinesin-1 adopts a hierarchical folding pattern. Z. Tan1, F. da Veiga Leprevost2, S. E. Haynes2, V. Basrur2, A. I. Nesvizhskii2, K. J. Verhey3, M. A. Cianfrocco4; 1Department of Biophysics, University of Michigan, Ann Arbor, MI, 2Department of Pathology, University of Michigan, Ann Arbor, MI, 3Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, MI, 4Life Sciences Institute, University of Michigan, Ann Arbor, MI.
5:50 pm M153 Architecture of the human inner kinetochore on intact mitotic chromosomes revealed by cryo-electron tomography. K. Kixmoeller, Y. Chang, B. Black; University of Pennsylvania, Philadelphia, PA.
6:05 pm M154 Structural convergence endows nuclear transport receptor Kap114p with a novel transcriptional repressor function toward TATA-box binding protein. C. Liao1,2, Y. Wang2, W. Pi3, C. Wang4, Y. Wu4, W. Chen3,5,6, K. Hsia1,2,3,6; 1Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and National Defense Medical Center, Taipei City, TAIWAN, 2Institute of Molecular Biology, Academia Sinica, Taipei City, TAIWAN, 3Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei City, TAIWAN, 4Institute of Biological Chemistry, Academia Sinica, Taipei City, TAIWAN, 5Cancer and Immunology Research Center, National Yang Ming Ciao Tung University, Taipei City, TAIWAN, 6Correspondence should be addressed to K.-C. H. (e-mail: khsia@gate.sinica.edu.tw) and W.-Y. C. (e-mail: chenwy@nycu.edu.tw), Taipei City, TAIWAN.
6:20 pm M155 CKAP5/XMAP215 facilitates microtubule-F-actin interaction and promotes F-actin bundling. L. Lowery1, B. Erdogan1, G. Cammarata1, P. Slater2, T. O'Brien1, J. Sabo3, M. Zdimalova3, V. Dostal4, S. Herynek3, L. Libusova4, A. Thawani5, M. Braun3, Z. Lansky3; 1Boston University, Boston, MA, 2Universidad San Sebastián, Santiago, CHILE, 3Czech Academy of Sciences, Prague West, CZECH REPUBLIC, 4Charles University, Prague, CZECH REPUBLIC, 5Princeton University, Princeton, NJ.
6:35 pm M156 Single-Molecule Insights into Kinesin-2 Motility and Its Role in Ciliopathies. S. Redford1, M. Friel1,2, N. Billington1,3, R. Liu1; 1Department of Biochemistry & Molecular Medicine, School of Medicine, West Virginia University, Morgantown, WV, 2Department of Natural Sciences, Fairmont State University, Fairmont, WV, 3Microscope Imaging Facility, West Virginia University, Morgantown, WV.
This session focuses on how physical forces intersect with molecular signaling to orchestrate cell fate and morphodynamics within multicellular systems.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology; and Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Haley Barlow, UMass Chan Medical School; and Matthew L. Kutys, University of California, San Francisco
5:20 pm M157 Optogenetic control of endogenous Rho signaling reveals biophysical principles of tissue morphogenesis. A. D. Countryman1, M. Herrera-Perez2, C. A. Doherty3, S. Y. Shvartsman3, K. E. Kasza2; 1Biomedical Engineering, Columbia University, New York, NY, 2Mechanical Engineering, Columbia University, New York, NY, 3Molecular Biology, Princeton University, Princeton, NJ.
5:35 pm M158 Curvature sensing mechanisms in single cells and epithelia. L. Pieuchot1, K. Anselme1, J. Milan2, V. Luchnikov1; 1CNRS, Mulhouse, FRANCE, 2Aix Marseille Univ, Marseille, FRANCE.
5:50 pm M159 Coordination of cell states and tissue architecture by mechanical forces. S. A. Wickstrom; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Muenster, GERMANY.
6:05 pm M160 An ancient mechanically-induced neuronal cell state promotes melanoma invasion. M. V. Hunter, M. H. Sherman, R. M. White; Memorial Sloan Kettering Cancer Center, New York, NY.
6:20 pm M161 All models are wrong (but some are useful): Xenopus embryonic epithelial sheets under strain in the real world. J. Yang1, E. Hearty1, Y. Wang1, L. A. Davidson2; 1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Bioengineering, Developmental Biology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA.
6:35 pm M162 Stem Cell Dancing Enhances Differentiation in 3D via Nuclear Mechanotransduction. M. Ayushman, G. Mikos, S. Sinha, S. Jones, X. Tong, F. Yang; Stanford University, Stanford, CA.
Misfolded proteins and their aggregates are highly toxic to cells and must be efficiently identified and eliminated. This session will focus on protein degradation as a key aspect of protein quality control.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Sriparna Ghosh, CaresBio Laboratory, LLC; and John Hanna, Harvard Medical School.
5:20 pm M163 Dissecting the role of TMED9, a p24-family member, in the clearance of misfolded GPI-anchored proteins via RESET pathway. E. Ronzier1, P. Satpute-Krishnan2; 1Henry Jackson Foundation, Bethesda, MD, 2Uniformed Services University of the Health Sciences, Bethesda, MD.
5:35 pm M164 HUWE1 amplifies the ubiquitin signal to promote the clearance of protein aggregates and condensates. Y. Lu1, M. Zhou1, R. Fang1, L. Colson1, K. Donovan2, M. Hunkeler2, Y. Song3, M. Kalocsay4, R. Eisert1, E. Fischer2; 1Harvard Medical Sch, Boston, MA, 2Dana-Farber Cancer Institute, Boston, MA, 3Massachusetts General Hospital, Boston, MA, 4MD Anderson Cancer Institute, Huston, TX.
5:50 pm M165 OTUB1 salvages folding-competent ubiquitinated nascent proteins. M. Mariappan, X. Li; Yale University, West Haven, CT.
6:05 pm M166 PI31/Fub1 is an Endogenous Proteasome Inhibitor that Functions Via a Novel Mechanism that Simultaneously Targets All Six Active Sites. J. Hanna1, S. Rawson1, R. Walsh1, B. Velez1, H. Schnell1, F. Jiao2, M. Blickling1, J. Ang1, M. Bhanu1, L. Huang2; 1Harvard Medical School, Boston, MA, 2University of California - Irvine, Irvine, CA.
6:20 pm M167 Unfolded Proteins Regulates Autophagy and Amino Acid Homeostasis through The Dynamics of CTPS Filaments. C. Wang1, W. Lin2, L. Pai1,2,3; 1Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City, TAIWAN, 2Molecular Medicine Research Center, Chang Gung University, Taoyuan City, TAIWAN, 3Department of Biochemistry, College of Medicine, Chang Gung University, Taoyuan City, TAIWAN.
6:35 pm M168 TMEDs as differential regulators of mutant membrane proteins. A. Goss1, M. Kost-Alimova2, K. Keller2, P. Byrne2, E. Grinkevich2, R. Muraleedharan2, J. Lin2, J. Pablo2, A. Greka2; 1Harvard Medical School, Boston, MA, 2Broad Institute of Harvard and MIT, Cambridge, MA.
Intracellular spatial organization underpins cellular functions in health and disease. In this symposium, we present new insights into localized metabolite and kinase signaling and the regulation of cellular functions via interorganelle and organelle-cytoskeleton interactions.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing; and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Michelle C. Mendoza, University of Utah; and Gulcin Pekkurnaz, University of California San Diego
5:20 pm M169 The guardians of mitochondrial metabolism: SoLute Carrier SLC25 family. H. Shen; Yale University, New Haven, CT.
5:35 pm M170 Mechanistic Regulation of Endoplasmic Reticulum-Mitochondria Contact Sites in Tumor Metabolic Rewiring. B. Chen, M. Elderany, P. Jadhav, T. Nguyen, J. Sexton, S. Mosalaganti, C. Lyssiotis, Y. Shah; University of Michigan, Ann Arbor, MI.
5:50 pm M171 A periodic organization of endoplasmic reticulum-plasma membrane contact sites organizes Ca2+release units allowing long distance propagation of Ca2+signals. L. Benedetti1, R. Fan2, A. Weigel1, A. S. Moore1, M. A. Kittisopikul1, C. J. Obara1, G. Park1, A. Petruncio1, P. Hubbard1, S. Xu3, S. Pang3, H. Hess1, V. Rangaraju2, S. Saalfeld1, P. De Camilli3, T. A. Ryan4, J. Lippincott-Schwartz1; 1HHMI Janelia Research Campus, Ashburn, VA, 2Max Planck Florida Institute for Neuroscience, Jupiter, FL, 3Yale University School of Medicine, New Haven, CT, 4Weill Cornell Medical Institute, New York, NY.
6:05 pm M172 A Novel Cytoskeleton-based Pathway Required for Maintenance of Mitochondria Dynamics and Energetics in Skeletal Muscle. D. Lorenzo1, K. M. Voos1, J. Tzeng1, P. Patel1, T. S. Pharr2, H. Choi2, S. Rubinsky1; 1University of Pennsylvania, Philadelphia, PA, 2University of North Carolina at Chapel Hill, Chapel Hill, NC.
6:20 pm M173 Self Organization of Glycolytic Activity into Cortical Waves Fuels Cell Migration and Cancer Progression. H. Zhan1, C. Janetopoulos1, D. S. Pal1, J. Borleis1, C. Huang2, P. N. Devreotes1; 1Cell Biology Department, Johns Hopkins University School of Medicine, Baltimore, MD, 2Pathology Department, Johns Hopkins University School of Medicine, Baltimore, MD.
6:35 pm M174 Focal Adhesion Kinase Phase Separation Regulates Autophosphorylation. N. Lea, L. Case; Massachusetts Institute of Technology, Cambridge, MA.
Session Co-Chairs Information
Cells in Distress and Disease
- Diego Acosta Alvear, Altos Labs
- Martina Bazzaro, Masonic Cancer Center-University of Minnesota
- Lai (Linda) Chan, Cleveland Clinic
- Jerry Edward Chipuk, Icahn Sch Medicine-Mount Sinai
- Sriparna Ghosh, CaresBio Laboratory, LLC
- John Hanna, Harvard Medical School
- David C. Michael, University of Bath
- Yasunori Saheki, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
- Kuo-Hui Su, The university of Toledo
- Julia von Blume, Yale School of Medicine
Cellular Dynamics
- Halil Aydin, University of Colorado Boulder
- Xianrui Cheng, University of Southern California
- P. C. Dave P. Dingal, The University of Texas at Dallas
- Sophie Dumont, University of California, San Francisco
- Rafael Garcia-Mata, University of Toledo
- Chuan-Hsiang Bear Huang, Johns Hopkins University School of Medicine Department of Pathology
- Antonis Kourtidis, Medical University of South Carolina
- Inna Nechipurenko, Worcester Polytechnic Institute
- Valentina Piano, University of Cologne
- Katerina Ragkousi, Amherst College
- Julia Romano, Johns Hopkins University
- Florian Schur, Institute of Science and Technology Austria
- Sichen (Susan) Shao, Harvard Medical School
- Vasundhara Sharma, Sartorius Stedim Biotech
- Mi Hye Song, Oakland University
- Yuyu Song, Harvard Medical School
- Alexander Sorkin, University of of Pittsburgh
- Suvranta K. Tripathy, University of Michigan - Dearborn
- Charlotte M. Vines, University of Texas-El Paso
- Thomas Wollert, Institut Pasteur
Cellular Genome
- Igor Cestari, Institute of Parasitology, McGill University
- Junnan Fang, Emory University School of Medicine
- Fei Li, Department of Biology, New York University
- Yaron Shav-Tal, Bar-Ilan University
Communal Cell
- Richa Arya, Banaras Hindu University, Varanasi INDIA
- Tara M. Finegan, University of Missouri
- Edgar R. Gomes, iMM - Lisbon
- Ernest G. Heimsath, Agilent Technologies, Inc
- Celeste M. Nelson, Princeton University
- Sandra Scharaw, Karolinska Institute
Physical Cell
- Haley Barlow, UMass Chan Medical School
- Nadir Kaplan, Virginia Tech
- Matthew L. Kutys, University of California, San Francisco
- Sahand Rahi, EPFL
- Stefanie Redemann, Sr., University of Virginia School of Medicine
- Vinay S Swaminathan, Lund University
Signaling and Metabolism
- Paulo Caceres, Henry Ford Hospital
- Carsten Gram Hansen, University of Edinburgh - Institute for Regeneration and Repair
- Chun-Yan Lim, Guangzhou National Laboratory, China
- Michelle C. Mendoza, University of Utah
- Alexander Muir, University of Chicago
- Gulcin Pekkurnaz, University of California San Diego
Specialized Cell and Evolution
- Shen-Ju Chou, Academia Sinica
- Alessandro Didonna, East Carolina University - Greenville, NC
- Huocong Huang, UT Southwestern Medical Center
- Georgia Rapti, EMBL
Education Minisymposium: Narrowing the Gap: Inclusive Teaching Strategies to Engage and Retain Students
- Kimberly Baker, University of Indianapolis
- Laurie Cook, SUNY Brockport
- Melville Vaughan, University of Central Oklahoma
Minisymposium Co-Chairs are responsible for scoring submitted abstracts, selecting talks for Minisymposia sessions from top-scoring abstracts, and introducing the speakers on the day of the Minisymposium. Please note co-chairs, or members of their labs, are only eligible to present a talk within their Minisymposium if they are in the top-scoring abstracts after the concealed review. There is not a reserved or guaranteed speaking slot for co-chairs, or members of their lab.
A minimum of four (4) and a maximum of ten (20) Minisymposium Co-Chairs will be selected per scientific meeting track, depending on the popularity of the track.
Minisymposium Co-Chairs will:
- Read and score up to 150 abstracts submitted to their scientific track. The abstracts will have author information concealed to reduce bias in scoring. The review period will take place between August 4 and August 18.
- Create a specified number of Minisymposia sessions, varying from two to 10 sessions depending on the track. Each Minisymposium session will consist of six (6) talks selected from top-scoring abstracts.
- Chair the session at Cell Bio 2022 in Washington, DC. Two Co-Chairs will work together to introduce the speakers in each Minisymposium, keep speakers on time, and moderate the live Q&A following each talk.
Diversity and Inclusion
ASCB is committed to ensuring that a diversified and inclusive program is presented to our attendees. Minisymposia Co-Chairs will be required to ensure talks selected are from presenters with diverse ethnic backgrounds, gender, research backgrounds, career-levels, geographic location.
Availability Requirements
Minisymposium Co-Chairs must be available during the following time periods
- Thursday, August 4 through Thursday, August 16 - Concealed Abstract Scoring Review Period
- Tuesday, August 23 through Tuesday, August 31- Formation of Minisymposia sessions with talk selections from top-scoring abstracts.
- Sunday, December 3 and Tuesday, December 5- Minisymposia sessions will be scheduled from approximately 3:40 pm to 5:10 pm and 5:40 pm to 7:10 pm on both Sunday, December 3 and Tuesday, December 5. You will need to be available for any of the four time slots.
Co-Chair Benefits
Minisymposia Co-Chairs will receive 50% off meeting registration via a coupon code provided by ASCB Staff.
Timeline & Key Dates
| Co-Chair Applications | Applications accepted to co-chair a Minisymposium. | Deadline: April 27 |
| Co-Chair Review | Program Committee Track Chairs review and score applications. | Late April to Late May |
| Co-Chair Notifications | Applicants are notified. | Late May/Early June |
| Abstract Submission | Abstracts accepted for consideration for Minisymposium Talks. There are 6 talks in each Minisymposium. | Opens Early June; Closes August 1 |
| Abstract Review | Minisymposia Co-Chairs review and score the abstracts and the weighted average score is used determine top-scoring abstracts in each scientific track. | August 4 to August 18 |
| Session Scheduling | Co-Chairs use top-scoring abstracts to create Minisymposia sessions. | August 23 to August 30 |
| Speaker Notification | Abstract submitters are notified. Co-Chairs also receive correspondence about their session. | By September 15 |