While it is known that two classes of actin nucleators, Arp2/3 and formins, regulate F-actin assembly, it remains unclear how…
Read MoreDeveloping cell-free transcription and translation systems is a key challenge in engineering synthetic cells. While lipid-derived compartmentalization of such systems…
Read MoreConventional dendritic cells type 1 (cDC1s) specialize in antigen “cross-presentation”, a mechanism that involves the presentation of exogenous antigens on…
Read MoreTo escape the immune system, trypanosome parasites remove antibodies bound to their cell surface via fast endocytosis. However, such high…
Read MoreAlthough most studies investigating the pathology of African trypanosomes, an extracellular protozoan parasite, have focused on parasites resident in the…
Read MoreTrypanosoma cruzi is a protozoan parasite that causes Chagas’ disease, a neglected tropical disease that kills approximately 50,000 people each…
Read MoreOligodendrocytes extend the plasma membrane surrounding axons with myelin sheaths. To accomplish this, oligodendrocytes rely on Golgi outposts, a compartment…
Read MoreDysfunctional telomeres in differentiated cells activate the ATM (ataxia telangiectasia-mutated)-dependent DNA damage response (DDR), leading to cell cycle arrest. However,…
Read MoreNET1 is a guanine nucleotide exchange factor for RhoA GTPase that plays different roles in the nucleus and cytoplasm. While…
Read MoreDividing cells assemble and constrict a contractile ring made up of actin and myosin anchored to the cell cortex. How…
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