Highlighted By: Samuel Dean, University of Warwick
Preprint DOI: https://doi.org/https://doi.org/10.1101/2023.07.20.549860
This preprint has been assigned the following Badges:
Significance Statement:
- To escape the immune system, trypanosome parasites remove antibodies bound to their cell surface via fast endocytosis. However, such high flux through the endocytic compartments has not yet been reconciled with the requirement for multiple fission and fusion events thought to occur between different endocytic compartments.
- Using electron tomography, super-resolution colocalization, and 3D immunogold co-labelling of cryosections, the authors show that the trypanosome endosomal system is comprised of interconnected fenestrated sheets, circular cisternae, and tubular structures, forming a single intricate endosome. This endosome is segregated into functional subdomains enriched with classical markers for early, late, and recycling endosomes.
- This may facilitate very fast plasma membrane recycling through facilitated diffusion, representing an important adaptation for trypanosome immune evasion and pathogenicity.
Read the Preprint:
Title: Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes
Fabian Link , Alyssa Borges , Oliver Karo , Marvin Jungblut , Thomas Müller , Elisabeth Meyer-Natus , Timothy Krüger , Stefan Sachs , Nicola G. Jones , Mary Morphew , Markus Sauer , Christian Stigloher , J. Richard McIntosh , Markus Engstler
doi: 10.1101/2023.07.20.549860
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This work is licensed under CC BY 4.0
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