Highlighted By: Vijayalakshmi V. Subramanian, Indian Institute of Science Education and Research (IISER) Tirupati
Preprint DOI: https://doi.org/10.1101/2023.01.13.523952
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Significance Statement:
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Age-dependent loss of cohesion is a determinant of aneuploidy in human oocytes. Mechanisms for how this loss is triggered with age are not known.
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Using oocytes from human participants of various ages, the authors correlate loss of Sgo2, a protector of cohesins, with age-related meiosis II cohesion defects including increased inter-kinetochore distances and single chromatids. High-resolution microscopy reveals age-dependent loss of Sgo2 specifically from pericentromeric bridges, but not from centromeric regions.
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This study highlights the role of pericentromeric cohesins in upholding sister-chromatid cohesion, even when centromeric cohesins are protected. This work is relevant to researchers interested in chromosome biology, meiosis, aneuploidy mechanisms, and fertility.
Read the Preprint:
Age-dependent loss of cohesion protection in human oocytes
Bettina P Mihalas, Gerard H Pieper, Cerys E Currie, David A Kelly, Geraldine M Hartshorne, Andrew D McAinsh, Richard A Anderson, Adele L Marston
bioRxiv 2023.01.13.523952; doi: https://doi.org/10.1101/2023.01.13.523952
This Preprint Highlight was previously published in Molecular Biology of the Cell on Apr 20, 2023: https://doi.org/10.1091/mbc.P23-04-0011
MBoC's Preprint Highlights are commentaries written by Early-Career Editors on recent preprints of interest. They do not constitute peer review or imply publication of the original preprint by MBoC. For more information, visit https://www.molbiolcell.org/curation-tools.
This work is licensed under CC BY 4.0
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