Join us for Cell Bio 2024, the joint meeting of ASCB and the European Molecular Biology Organization (EMBO). This is your opportunity to network with scientists, present your research, explore the exhibit hall, and learn the latest cell biology science and technology.
Preprint Highlight: Age-dependent loss of cohesion protection in human oocytes
Age-dependent loss of cohesion is a determinant of aneuploidy in human oocytes. Mechanisms for how this loss is triggered with age are not known. Using oocytes from human participants of various ages, the authors correlate loss of Sgo2, a protector of cohesins, with age-related meiosis II cohesion defects including increased inter-kinetochore distances and single chromatids….
Preprint Highlight: 7-UP: generating in silico CODEX from a small set of immunofluorescence markers
Multiplexed molecular imaging enables the characterization of the spatial organization of different cell types in their native tissue context but is an expensive and labor-intensive technology. This study presents 7-UP, a method that computationally generates 40 protein expression markers, at single-cell resolution, from a panel of seven experimentally measured multiplexed immunofluorescence markers. The method relies…
Preprint Highlight: Learning orientation-invariant representations enables accurate and robust morphologic profiling of cells and organelles
One application of deep learning in analysis of cell biological microscopy data is developing meaningful quantitative representations of cellular and/or molecular phenotypic signatures. Because image orientation has no relevance for shape and morphology, encoding orientation within such representations confounds downstream analyses. This study presents O2-VAE, a neural method for learning orientation-invariant, image-based shape representations. The…
Preprint Highlight: Lateral and longitudinal compaction of PRC1 overlap zones drives stabilization of interzonal microtubules
Midzone microtubules, which support chromosome segregation during anaphase and define the cell division plane, transition from being dynamic in early anaphase to being stable in late anaphase. The mechanism of midzone microtubule stabilization is not well understood. Using photoactivation experiments, the authors find reduced turnover and sliding of midzone microtubules during late anaphase, after 50%…
Preprint Highlight: Constriction forces imposed by basement membranes regulate developmental cell migration
Extracellular matrix (ECM) stiffness affects many processes of ECM-associated cells, such as migration and differentiation. Whether ECM mechanical properties also affect distant cell populations remains largely unexplored. This preprint studies migration of border cells within Drosophila ovarian follicles as a model system. Border cells migrate toward the center of the follicle by moving between nurse…
COMPASS: Navigating Trainee Professional Development
Trainee-led professional development programming is an essential component of the ASCB Annual Meeting, and a key tenet of ASCB’s Strategic Plan to “expand and coalesce career and professional development offerings at the Annual Meeting.” The Committee for Postdocs and Students (COMPASS) was founded in 2013 to provide a platform for trainee professional development and trainee…
Molecular Biology of the Cell (MBoC)
Molecular Biology of the Cell (MBoC) is a premier journal for research in all areas of cell biology, from biophysics to genetics to neuroscience. Its 14 online issues per year include Special Issues in the important areas of Quantitative Cell Biology, and Forces on and within Cells. Readers and authors alike benefit from the journal’s review process, which offers authors constructive feedback by working scientists.
CBE—Life Sciences Education (LSE)
CBE—Life Sciences Education (LSE) is a peer-reviewed journal of life science education research and evidence-based practice published by the ASCB in editorial partnership with the Genetics Society of America and partially funded by Howard Hughes Medical Institute. Online and completely free, LSE emphasizes teaching innovations and evidence of their effectiveness and is designed for educators at all levels and across all life science disciplines.
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