Minisymposium 13: Cell Death and Genome Instability

Tuesday, 4:15-6:50 pm
Room 103
Co-Chairs: Ingrid Wertz, Genentech, Inc.; and Junying Yuan, Harvard Medical School

4:15 pm       Introduction

4:20 pm   M131    RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Y. Ito1, D. Ofengeim1, J. Yuan1; 1Cell Biology, Harvard Medical School, Boston, MA

4:35 pm   M132    Helicobacter pylori infection promotes genomic instability through a caspase-dependent pathway without promoting cell death. A. Zamperone1, D. Cohen1, A. Muesch1; 1Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY

4:50 pm   M133    Cause and mechanism of Xenopus hybrid unviability. R. Gibeaux1, R. Heald1; 1Department of Molecular  Cell Biology, University of California, Berkeley, CA

5:05 pm   M134    Catastrophic Chromosome Shattering in Micronuclei Is Coupled to Inaccurate Reassembly by Canonical End Joining. P. Ly1,2, L.S. Teitz3,4, D.H. Kim1,2, O. Shoshani1,2, H. Skaletsky3,5, D. Fachinetti6, D.C. Page3,4,5, D.W. Cleveland1,2; 1Ludwig Institute for Cancer Research, La Jolla, CA, 2Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 3Whitehead Institute for Biomedical Research, Cambridge, MA, 4Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 5Howard Hughes Medical Institute, Cambridge, MA, 6CNRS UMR144, Institut Curie, Paris, France

5:20 pm   M135    Determining the missegregation rates of individual human chromosomes. J.T. Worrall1, S.E. McClelland1; 1Centre for Molecular Oncology, Barts Cancer Institute, London, United Kingdom

5:35 pm   M136    Small Molecule Antagonists of the Deubiquitinase USP7 Interfere with Ubiquitin Binding. I.E. Wertz1; 1Departments of Molecular Oncology and Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA

5:50 pm   M137    Covalent irreversible inhibitors of USP7 as small molecule cancer immunotherapy agents. J. Wang1, J. Wu1, L. Wang2, I. Sokirniy1, H. Wang1, P. Nguyen1, J. Weinstock1, M. Mattern1, W.W. Hancock2, S. Kumar1; 1Progenra, Malvern, PA, 2Children’s Hospital of Philadelphia, Philadelphia, PA

6:05 pm   M138    Targeting endoplasmic reticulum-resident proteins for the treatment of B cell cancer. C.A. Tang1, J. Del Valle2, C.A. Hu1; 1The Wistar Institute, Philadelphia, PA, 2Department of Chemistry, The University of South Florida, Tampa, FL

6:20 pm   M139    Endosomal interactions with mitochondria during mitochondrial outer membrane permeabilization. N.R. Brady1, A. Hamacher-Brady1; 1Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD

6:35 pm   M140    Genetically encoded fluorogenic protease reporters visualize spatiotemporal dynamics of apoptosis in vivo. X. Shu1; 1Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA