Cancer: From genome instability to therapy

2019 ASCB DOORSTEP MEETING

**Walter E. Washington Convention Center, East Salon * December 7, 2019**

ABOUT

The Doorstep Meeting features leaders in genome instability and therapies who have studied mechanisms by which cancer cells respond.

This full-day meeting will take place on Saturday, December 7, 2019 in Washington, DC from 8:00 am – 4:15 pm. The meeting is being organized by Karlene Cimprich, Stanford University, and David Pellman, Harvard Medical School and Dana Farber Cancer Institute.

ORGANIZERS

Karlene Cimprich

Stanford University School of Medicine

The focus of the Cimprich lab is on understanding how cells maintain genomic stability, particularly during DNA replication, where many challenges threaten its accurate completion and can lead to DNA damage. This is a complex, multi-faceted process and the lab is investigating how cells sense DNA damage during replication, choose between possible responses to stalled replication forks, and coordinate transcription with DNA replication.

David Pellman

Dana-Farber Cancer Institute & Children's Hospital, Boston/HHMI

David Pellman studies normal cell division mechanisms and the cell division defects of cancer cells. He seeks to understand how cell division defects, particularly defects in mitosis, shape cancer genomes. His work may lead to the development of new therapeutic strategies for cancer.

ATTENDEES

MINUTES OF DEDICATED NETWORKING INCLUDING POSTERS

EXPERT INVITED SPEAKERS

SPEAKERS

Andrea Ablasser

École Polytechnique Fédérale de Lausanne

Andrea Ablasser studied Medicine at the University of Munich, GER, and received her MD in 2010. After a post-doctoral stay at the University of Bonn, GER, she joined the Swiss Federal Institute of Technology, Lausanne, CH, in 2014 as tenure-track assistant professor. Ablasser`s research focuses on mechanisms of intracellular sensing of DNA - a fundamental strategy of innate immunity.

Samuel Bakhoum

Memorial Sloan Kettering Cancer Center (MSKCC)

Samuel Bakhoum is currently an Assistant Member (Professor) in the Human Oncology and Pathogenesis Program and the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center (MSKCC). His laboratory focuses on understanding the consequences of chromosomal instability on tumor evolution, centering on cancer metastasis and tumor-immune interaction. Samuel obtained his M.D., Ph.D. at the Geisel School of Medicine at Dartmouth.

James Chen

UT Southwestern

Dr. Chen is a George L. MacGregor Distinguished Chair in Biomedical Science, director of the Inflammation Research Center, and a professor of molecular biology at the University of Texas Southwestern Medical Center.

Irene Chiolo

University of Southern California

Research in Professor Chiolo’s laboratory focuses on the mechanisms of DNA repair in heterochromatin. Using the Drosophila system, currently the best working model for heterochromatin repair studies, research in my lab aims to identify the mechanisms involved, and to address how they protect genome integrity at cellular and organismal levels. This research will ultimately contribute to our understanding of human diseases associated with genome instability, including cancer, aging, and developmental defects.

Jan Lammerding

Cornell University

In the Lammerding laboratory, we investigate this intricate interplay between cellular structure, mechanics and function through an interdisciplinary research approach that combines engineering principles, microfabrication, and cell and molecular biology techniques, as well as the development and application of novel experimental assays.

Serena Nik-Zainal

University of Cambridge

Dr. Nik-Zainal is a CRUK Advanced Clinician Scientist and Honorary Consultant in Clinical Genetics in Cambridge, UK. Serena went to the UK as a PETRONAS scholar from Malaysia in 1993, obtaining a First in Physiology at the University of Cambridge before completing her medical degree in 2000. She trained as a physician and specialized in Clinical Genetics. She undertook a PhD at the Wellcome Sanger Institute in 2009 pioneering exploration of breast cancers through whole genome sequencing (WGS).

Michael Yaffe

MIT

Michael B. Yaffe studies the chain of reactions that controls a cell’s response to stress, cell injury, and DNA damage. The goal of our research is to understand how signaling pathways are integrated at the molecular and systems level to control cellular responses. We are particularly interested in: (1) signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy; and (2) cross-talk between inflammation, cytokine signaling and cancer.

"The amount of opportunity we had to network was unlike any other meeting I've ever experienced"