Subgroup K: Neuronal Cytoskeleton: Cytoarchitecture and Dynamics (Room 33B)

Saturday, December 12, 1:00 pm–5:00 pm

ORGANIZERS: Anthony Brown, Ohio State University; Stephanie Gupton, University of North Carolina at Chapel Hill; Laura Ann Lowery, Boston College; and Subhojit Roy, University of California, San Diego

 

Nerve cells extend and maintain long and sometimes elaborately branched processes, axons and dendrites, which define the wiring pattern of the nervous system. This unique and highly polarized morphology is critically dependent on the cytoskeleton, including the specialized and regulated cytoskeletal machinery that generates the dynamic molecular architecture of axonal and dendritic microdomains such as growth cones, synaptic boutons, nodes of Ranvier, axon initial segments, branch points and dendritic spines. This session will highlight exciting findings on the dynamics and cytoarchitecture of the cytoskeleton in these regions of axons and dendrites and their function in axon guidance, extension and regeneration, and in dendritic plasticity and morphogenesis.

 

PRESENTATIONS:

1:00–1:05 pm Opening remarks. Anthony Brown, Ohio State University; Stephanie Gupton, University of North Carolina at Chapel Hill; Laura Ann Lowery, Boston College; and Subhojit Roy, University of California San Diego
1:05–1:25 pm Interplay between the cytoskeleton and scaffolds at the axon initial segment. Christophe Leterrier, CNRS, Aix-Marseille Université
1:30–1:40 pm Novel actin organization and dynamics in the axon shaft. Archan Ganguly, University of California, San Diego
1:45–2:05 pm Coordination of axonal cytoskeletal dynamics by mitochondria. Gianluca Gallo, Shriners Hospitals Pediatric Research Center, Temple University
2:10-2:30 pm Regulation of microtubule plus-end dynamics during axon outgrowth. Laura Ann Lowery, Boston College
2:35–2:55 pm A filopodia stability switch for axon guidance. Stephanie Gupton, University of North Carolina Chapel Hill
3:00–3:15 pm Break
3:15–3:25 pm Slit stimulates filopodium formation and elongation to mediate repulsive axon guidance. Russell McConnell, Massachusetts Institute of Technology
3:30–3:50 pm Conditioning drives axon regeneration by Cofilin-mediated actin turnover. Frank Bradke, German Center for Neurodegenerative Diseases (DZNE)
3:55–4:15 pm Cytoskeletal dynamics of the regenerating axon. Andrew Chisholm, University of California, San Diego
4:20–4:30 pm The Down syndrome critical kinase, Minibrain/Dyrk1a, controls dendrite morphogenesis through direct regulation of the microtubule cytoskeleton. Kassandra Ori-McKenny, University of California, Davis
4:35–4:55 pm A new cytoskeletal model for trafficking material to dendritic spines during synaptic plasticity. Erik Dent, University of Wisconsin, Madison

 

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