Time (in ET)Description
10:30 – 10:35 AMWelcome Remarks
by Erika Holzbaur and Andrea Stavoe
10:35 – 10:55 AMSpeaker:
George Langford, Syracuse University
10:55 – 11:25 AMSpeaker:
Pietro De Camilli, Yale University
11:25 – 11:55 AMSpeaker:
Frank Bradke, German Center for Neurodegenerative Diseases
11:55 – 12:05 PMBreak
12:05 – 1:05 PMShort Talks (Round 1):

12:05-12:11pm
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury in familial and sporadic ALS
Alyssa Coyne, Johns Hopkins University School of Medicine

12:11-12:17pm
Elucidating the Cellular Functions of Timm50, a Mitochondrial Transport Protein, in Neurons and Astrocytes
Eyal Paz, Tel Aviv University

12:17-12:23pm
Ribosome collisions fuel a vicious cycle of neurotoxicity in Huntington’s Disease
Ranen Aviner, Stanford University

12:23-12:29pm
ER stress-induced JNK promotes stress granule formation via epigenetic modifications in C9orf72 mediated ALS/FTD
Sahana Gopalakrishna, Mayo Clinic

12:29-12:35pm
Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9
Sisi Yang, Yale University

12:35-12:41pm
Modulating Histone Modifications in ALS/FTD: New Avenues for Suppressing Toxicity of Neurodegenerative Disease Proteins
Mariana Torrente, Brooklyn College/City University of New York

12:41-12:47pm
SHIP164 is a Chorein Motif Containing Lipid Transport Protein that Controls Membrane Dynamics and Traffic at the Endosome-Golgi Interface
Michael Hanna, Yale University

12:47-12:53pm
ER network stability promotes organized microtubule disassembly during Compartmentalized Cell Elimination
Piya Ghose, The University of Texas at Arlington

12:53-12:59pm
Activation of the CaMKII-Sarm1-ASK1 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria
Chen Ding, Yale University

12:59-1:05pm
In Vitro Reconstituted Stress Granule-Like Condensates are Nucleation Sites for Aggregation of Misfolded Proteins
Andrii Kopach, International Institute of Molecular and Cell Biology in Warsaw
1:05 – 1:25 PMLunch & Networking (Round 1)
Topic: Science
1:25 – 1:45 PMLunch & Networking (Round 2)
Topic: Science
1:45 – 2:15 PMLunch & Networking (Round 3)
Topic: Inclusion in Cell Biology
2:15 – 3:15 PMShort Talks (Round 2):

2:15pm – 2:21pm
Mitochondria-lysosomes crosstalk alterations and neurodegeneration: Charcot-Marie-Tooth type 2B as the paradigm of nervous peripheral damage
Flora Guerra, University of Salento

2:21pm – 2:27pm
Phase Separation at the Synapse: Material Properties and Functional Implications
Dragomir Milovanic, German Center for Neurodegenerative Diseases (DZNE)

2:27pm – 2:33pm
Kinesin-13 regulates developmental pruning of dendrites in the PVD neurons of Caenorhabditis elegans
Swagata Dey, National Brain Research Centre, Manesar, India

2:33pm – 2:39pm
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
Jeeyun Chung, Harvard University

2:39pm – 2:45pm
Spastic paraplegia protein ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics
Rebecca Smith, University of Cambridge

2:45pm – 2:51pm
DLK regulates mitochondrial fission by phosphorylating DRP1 after axonal injury
Jorge Gomez Deza, National Institutes of Health

2:51pm – 2:57pm
ApoE targets astrocyte cytoplasmic lipid droplets to modulate phosphatidylcholine metabolism and droplet size
Ian Windham, University of North Carolina at Chapel Hill

2:57pm – 3:03pm
Exploring The Role of the E3 Ubiquitin Ligase TRIM9 in Alzheimer’s Disease
Charise White, University of North Carolina at Chapel Hill

3:03pm – 3:09pm
TPPP Forms Liquid Condensates and Aggregates in Multiple System Atrophy
Shahrnaz Kemal, National Institutes of Health

3:09pm – 3:15pm
Insulin signaling enhances the anterograde speed of Rab4-associated vesicles in the cholinergic neurons of Drosophila
Kamaldeep Singh, Tata Institute of Fundamental Research Mumbai, India
3:15 – 3:25 PMBreak
3:25 – 3:55 PMPanel Session:
Developing Therapeutic Approaches to Neurodegenerative Disease
Shalini Padmanbhan, The Michael J. Fox Foundation for Parkinson’s Research
Lucie Bruijn, AveXis, Inc.
3:55 – 4:25 PMSpeaker:
Ai Yamamoto, Columbia University
4:25 – 4:55 PMSpeaker:
Andrea Stavoe, UTHealth McGovern Medical School
4:55 – 5:00 PMClosing Remarks

Program Chairs

Erika Holzbaur
William Maul Measey Professor of Physiology
University of Pennsylvania Perelman School of Medicine
Andrea Stavoe
Assistant Professor, Neurobiology and Anatomy
University of Texas Health McGovern Medical School

2021 Doorstep Meeting:

The Cell Biology of Neurodegeneration and Repair
November 30, 2021
10:00 AM to 5:00 PM EST
Location: Virtual

Back to Cell Bio Virtual 2021 meeting site