December 1-10, 2021
#cellbio2021
Minisymposia
Minisymposia sessions offer the most groundbreaking research representing each of the seven scientific meeting tracks at Cell Bio Virtual 2021. Top-scoring abstracts submitted to each scientific track will be scheduled into Minisymposium sessions. There are be 28 total scientific Minisymposia and one Education Minisymposium at the Cell Bio Virtual 2021 meeting.
Click here to view all Minisymposia Co-Chairs.
See below for full details on each session.
Minisymposia Sessions and Schedule
Wednesday, December 1, 10:30 am to 12:00 pm EST
Track(s): Education and Professional Development
Co-Chairs: Kimberly Baker, University of Indianapolis, Stephanie Levi Blumer, Oakton Community College, and Marina Crowder, University of California, Davis
10:30 am EM1 Evaluating the Impact of Student Created Videos in an Undergraduate Biology Classroom. K. Hefferon; Cornell University, Ithaca, NY.
10:45 am EM2 Student outcomes from a large-enrollment undergraduate introductory course-based undergraduate research experience in remote learning with laboratory kits sent to students. S. M. Lo; University of California San Diego, La Jolla, CA.
*11:00 am EM3 The Cell Biology Education Consortium. Building an Undergraduate Research Infrastructure. N. S. Reyna, M; Biology, Ouachita Baptist University, Arkadelphia, AR.
11:15 am EM4 Challenges and opportunities for students with disabilities in undergraduate research. L. E. Gin, D. A. Pais, K. M. Cooper, S. E. Brownell; School of Life Sciences, Arizona State University, Tempe, AZ.
11:30 am EM5 Examining how graduate research and teaching affect depression in life sciences Ph.D. students. K. Cooper, L. Gin, N. Wiesenthal; Arizona State University, Tempe, AZ.
11:45 am EM6 Reflections on Inclusive Excellence 1&2 and building capacity for institutional change in science education.. M. Juarez; Howard Hughes Medical Institute, Bethesda, MD.
* Reyna is the Innovation in Education awardee.
Monday, December 6, 11:30 am to 1:00 pm EST
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chair: Nuno Raimundo, Penn State University, and Hongying (Hoy) Shen, Yale University
11:30 am M1 Combinatorial G x G x E CRISPR screen of mitochondrial SLC25 carriers reveals their metabolic state dependency. X. Shi1, B. Reinstadler2, H. Shah2, T. To3, K. Byrne1, L. Summer1, S. Calvo3, O. Goldberger2, J. Doench3, V. Mootha2, H. Shen1; 1Yale University, New Haven, CT, 2Massachusetts General Hospital, Boston, MA, 3Broad Institute, Cambridge, MA.
*11:45 am M2 Deciphering the role of mitochondrial redox metabolism in cell proliferation. K. Birsoy; Rockefeller University, New York, NY.
12:00 pm M3 Optogenetic modification of membrane lipids using engineered Phospholipase Ds. R. Tei, J. Baskin; Cornell University, Ithaca, NY.
12:15 pm M4 Decoupling Mitochondrial Morphology and Activity as a Function of Metabolic State? G. Singh1, V. Vengayil1, S. Laxman2; 1The Institute for Stem Cell Science and Regenerative Medicine, Bangalore, INDIA, 2Regulation of Cell Fate, The Institute for Stem Cell Science and Regenerative Medicine, Bangalore, INDIA.
12:30 pm M5 Mitochondrial energy dysfunction induces remodeling of the cardiac mitochondrial protein acylome. J. Peoples1, N. Ghazal1, D. Duong2, K. Hardin3, N. Seyfried4, V. Faundez5, J. Kwong1; 1Pediatrics, Emory University School of Medicine, Atlanta, GA, 2Biochemistry, Emory University, Atlanta, GA, 3Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA, 4B, Emory University School of Medicine, Atlanta, GA, 5Cell Biology, Emory University School of Medicine, Atlanta, GA.
12:45 pm M6 The p97-UBXD8 complex regulates ER-mitochondria contacts. M. Raman1, R. Ganji1, J. Paolo2, J. Purdy3, S. Gygi2; 1Developmental Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 2Cell Biology, Harvard Medical School, Boston, MA, 3Dept. of Immunology, University of Arozona, Tucson, AZ.
*Birsoy is the Innovation in Research Awardee.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Vaishnavi Ananthanarayanan, EMBL Australia Node in Single Molecule Science, University of New South Wales, Australia, and Ekaterina Grishchuk, Perelman School of Medicine, University of Pennsylvania
11:30 am M7 Branched actin, microtubule motors, and heterochromatin function together to move nuclei through constricted spaces in C elegans. J. Ho1, L. Ma1, E. Gregory1, L. Guerrero1, D. Libuda2, D. Starr1; 1University California-Davis, Davis, CA, 2University of Oregon, Eugene, OR.
11:45 am M8 Differential regulation and fine tuning of kinesin and dynein motility by microtubule-associated septin complexes. A. Suber, K. Nakos, E. Spiliotis; Drexel University, Philadelphia, PA.
12:00 pm M9 Septins guide non-centrosomal microtubules to promote focal adhesion disassembly in migrating cells.. D. Merenich1, K. Nakos2, T. Pompan1, S. Donovan1, A. Gill1, P. Patel1, E. T. Spiliotis2, K. A. Myers1; 1University of the Sciences in Philadelphia, Philadelphia, PA, 2Drexel University, Philadelphia, PA.
12:15 pm M10 Vimentin Regulates Collagen Remodeling by Controlling the Aggregation of Myosin 10 at the Termini of Cell Extensions. Z. Ostrowska-Podhorodecka1, I. Ding1, S. Abbasi1, P. D. Arora1, T. H. F. Wong1, C. Ji2, Y. Wang1, K. Carneiro1, C. A. McCulloch1; 1Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA, 2bDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, CANADA.
12:30 pm M11 Sub-centrosomal mapping identifies augmin-gammaTuRC as part of a centriole-stabilizing scaffold. N. Schweizer1, L. Haren2, I. Dutto1, R. Viais1, C. Lacasa1, A. Merdes2, J. Luders1; 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, SPAIN, 2Molecular, Cellular and Developmental Biology, Centre de Biologie Intégrative, CNRS-Université Toulouse III, Toulouse, FRANCE.
12:45 pm M12 Microtubule dynamics are required for mammary epithelial cell migration and branching morphogenesis. A. K. Fraser, J. P. Carreras, I. A. Ryan, A. J. Ewald; Cell Biology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Thelma Escobar, University of Washington, and Sean E. Hanlon, National Institutes of Health
11:30 am M13 Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ. Z. Tan1, S. Cai1, A. J. Noble2, J. K. Chen1, J. Shi1, L. Gan1; 1National University of Singapore, Singapore, SINGAPORE, 2National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, and, New York, NY.
11:45 am M14 Quantitative image-based analysis of organization and reorganization of nuclear structures in hiPSCs and hiPSC-derived cardiomyocytes. C. L. Frick, .. Allen Institute for Cell Science, S. Rafelski; Allen Institute for Cell Science, Seattle, WA.
12:00 pm M15 Appling cryo-EM single-particle analysis to Xenopus egg extract system to understand structural mechanics behind chromosome architecture during the cell cycle. Y. Arimura, H. Funabiki; Rockefeller University, New York, NY.
12:15 pm M16 A Systematic Analysis of Argonaute Proteins in C. elegans. U. Seroussi, A. G. Charlesworth, M. S. Renaud, A. E. Sundby, R. X. Lao, A. R. Willis, W. Zhao, R. I. Molnar, A. D. Reinke, J. M. Claycomb; Molecular Genetics, University of Toronto, Toronto, ON, CANADA.
12:30 pm M17 Differential Genome Utilization In Early Development. H. Chen1, M. C. Good1,2; 1Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.
12:45 pm M18 Single Molecule In Situ Imaging of DNA Repair in Single Human Cells. P. Zrazhevskiy1, V. Nandakumar1, W. Kerwin1, R. Wang2, T. Ragoczy1, A. Funnell1, J. Stamatoyannopoulos2; 1Altius Institute for Biomedical Sciences, Seattle, WA, 2Altius Institute for Biomedical Sciences & University of Washington, Seattle, WA.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems
Co-Chairs: Sandra E. Encalada, Scripps Research, and Eric Adam Vitriol, Medical College of Georgia, Augusta University
11:30 am M19 Neuritogenesis in pyramidal neurons requires spatial coordination of actin protrusion and contractility by a novel network of septin filaments. M. R. Radler, E. T. Spiliotis; Biology, Drexel University, Philadelphia, PA.
11:45 am M20 Dendritic architecture determines mitochondrial distribution patterns in vivo. E. Donovan1, N. Liberman1, J. Kalai1, A. Agrawal2, E. Koslover2, E. Barnhart1; 1Columbia University, New York, NY, 2UC San Diego, San Diego, CA.
12:00 pm M21 Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. S. Yang1, D. Park1, L. Manning1, S. E. Hill1, M. Cao1, Z. Xuan1, I. Gonzalez1, E. M. Wisdom1, L. Shao1, I. Okeke2, P. D. Camilli1, D. A. Colón-Ramos1; 1Program in Cellular Neuroscience, Neurodegeneration and Repair, Departments of Neuroscience and Cell, Yale University, New Haven, CT, 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.
12:15 pm M22 Endoplasmic reticulum-lysosome interactions promote autophagy to regulate synaptic growth. R. Thakur1, C. Hogan2, K. O’Connor-Giles1,3; 1Department of Neuroscience, Brown University, Providence, RI, 2Department of Genetics, University of Wisconsin, Madison, WI, 3Carney Institute for Brain Science, Providence, RI.
12:30 pm M23 Nudc-dependent regulation of the axon terminal cytoskeleton in neurons. D. Kawano1, K. Pinter2, K. Drerup3; 1Stanford University, Palo Alto, CA, 2National Institute on Deafness and Communication Disorders, Bethesda, MD, 3University of Wisconsin-Madison, Madison, WI.
12:45 pm M24 Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons. J. Goldsmith1, A. Ordureau2, J. W. Harper3, E. L. F. Holzbaur1; 1University of Pennsylvania, Philadelphia, PA, 2Sloan Kettering Institute, New York, NY, 3Harvard Medical School, Boston, MA.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Fei Geng, McMaster University, Canada, and Mark A. LaBarge, City of Hope
11:30 am M25 The innate immunity sensor STING contributes to mitochondria dysfunction and muscular degeneration in a Drosophila melanogaster model of hereditary Parkinson’s disease. A. T. Moehlman1,2, R. J. Youle2; 1National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, 2Biochemistry Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
11:45 am M26 Impaired activity of the mitophagy regulator TBK1 is partially compensated by ULK1 but disrupts mitochondrial quality control in neurons. O. Harding1, C. S. Evans2,1, E. L. F. Holzbaur1; 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Cell Biology, Duke University, Durham, NC.
12:00 pm M27 Active Mechanisms Prevent Ectopic Condensation of FG Nucleoporins in the Cytoplasm. L. Thomas1, B. Taleb1, P. Askjaer2, G. Seydoux1; 1HHMI and Johns Hopkins University School of Medicine, Baltimore, MD, 2Andalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, Seville, SPAIN.
12:15 pm M28 TorsinA regulates nuclear pore complex assembly and localization during neuronal maturation. S. Kim1, S. Phan2, D. Boassa2, S. S. Pappas3, M. H. Ellisman2, S. J. Barmada4, W. T. Dauer3; 1Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 2National Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA, 3Peter O’Donnell Jr. Brain Institute, UT Southwestern, Dallas, TX, 4Department of Neurology, University of Michigan Medical School, Ann Arbor, MI.
12:30 pm M29 RNA-based regulation of TDP-43 nuclear export. L. Duan, B. Zaepfel, J. Rothstein, P. Kalab, L. R. Hayes; Johns Hopkins University, Baltimore, MD.
12:45 pm M30 Ataxin-2 polyQ expansions disrupt the liquid-like properties and anterograde transport of neuronal TDP-43 ribonucleoprotein condensates in the axon and suppress mRNA translation. D. Wijegunawardana, S. S. Vishal, P. P. Gopal; Pathology Department, Yale University, New Haven, CT.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Shirin Bahmanyar, Yale University, and Jonathan Friedman, UT Southwestern Medical Center
11:30 am M31 Taok2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. K. Nourbakhsh, A. Ferreccio, M. Bernard, S. Yadav; University of Washington, Seattle, WA.
11:45 am M32 Myo19-mediated F-actin tethering induces mitochondrial fragmentation. S. Coscia, E. Baltrusaitis, M. Lakadamyali, E. Holzbaur; University of Pennsylvania, Philadelphia, PA.
12:00 pm M33 Limiting ER membrane biogenesis prior to cell entry into mitosis ensures its reorganization to allow chromosome motions necessary for mitotic fidelity. H. Merta1, J. W. Carrasquillo Rodríguez1, M. I. Anjur-Dietrich2, T. Vitale1, M. E. Granade3, T. Harris3, D. Needleman4, S. Bahmanyar1; 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 2Department of Applied Physics, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 3Department of Pharmacology, University of Virginia, Charlottesville, VA, 4Department of Applied Physics and of Molecular and Cell Biology, Harvard University, Cambridge, MA.
12:15 pm M34 Invadopodia formation is spatiofunctionally coupled to the nuclear envelope by septin GTPases. J. Okletey1, T. Jones1, C. Montagna2, E. Spiliotis1; 1Drexel University, Philadelphia, PA, 2Albert Einstein College of Medicine, Bronx, NY.
12:30 pm M35 Non-vesicular lipid transport mediated by PDZD-8 and TEX-2 promote robust embryogenesis via regulation of endosomal PI(4,5)P2 homeostasis in C. elegans. D. Jeyasimman1, B. Ercan1, D. Dharmawan1, T. Naito1, J. Sun1, Y. Saheki1,2; 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SINGAPORE, 2Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, JAPAN.
12:45 pm M36 Membrane Fusion Machinery Mediates Protein Targeting from the Endoplasmic Reticulum to Lipid Droplets. J. Song1,2,3, A. Mizrak1,2, M. Cicconet2, Z. Lai1,2, C. Lu1,2, S. Mohr4, R. Farese, Jr.1,2,5, T. Walther1,2,5,6; 1Department of Molecular Metabolism, Harvard Chan School of Public Health, Boston, MA, 2Department of Cell Biology, Harvard Medical School, Boston, MA, 3Harvard/MIT MD-PhD program, Harvard Medical School, Boston, MA, 44DRSC/TRiP Functional Genomics Resources & DRSC-BTRR, Department of Genetics, Harvard Medical School, Boston, MA, 5Broad Institute of MIT and Harvard, Cambridge, MA, 6Howard Hughes Medical Institute, Chevy Chase, MD.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Margarida M. Barroso, Albany Medical College, and Partha Roy, University of Pittsburgh
11:30 am M37 Lateral transfer of macrophage mitochondria drives ERK signaling to promote cancer cell proliferation. J. CASALINI, C. Kidwell, J. S. Johnson, M. Roh-Johnson; Biochemistry, University of Utah, Salt Lake City, UT.
11:45 am M38 Investigating EGFRvIII extrinsic regulation of GBM invasion. M. J. Barraza1, A. Banisadr2, F. B. Furnari3, A. J. Engler4,5; 1Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, 2Turning Point Therapeutics, San Diego, CA, 3Department of Pathology, University of California, San Diego, La Jolla, CA, 4Department of Bioengineering, University of California, San Diego, La Jolla, CA, 5Sanford Consortium for Regenerative Medicine, La Jolla, CA.
12:00 pm M39 Mrtf-srf interaction is essential for metastatic colonization . D. Gau1, P. Chawla1, M. Joy2, D. Boone1, P. Lucas2, P. Roy1; 1University of Pittsburgh, Pittsburgh, PA, 2UPMC Hillman Cancer Center, Pittsburgh, PA.
12:15 pm M40 Investigating the molecular mechanisms underlying efficient metastatic extravasation. B. C. Traub1,2,3, L. Boriello2,3, A. Coste1,2,3, M. Oktay2,4, J. Condeelis2,3,5, D. Entenberg2,3,5; 1Department of Surgery, Albert Einstein College Med - Bronx, NY, Bronx, NY, 2Department of Anatomy and Structural Biology, Albert Einstein College Med - Bronx, NY, Bronx, NY, 3Gruss-Lipper Biophotonics Center, Albert Einstein College Med - Bronx, NY, Bronx, NY, 4Department of Pathology, Albert Einstein College Med - Bronx, NY, Bronx, NY, 5Integrated Imaging Program, Albert Einstein College Med - Bronx, NY, Bronx, NY.
12:30 pm M41 Measuring Drug-Induced Changes in ERK Activity on a Single Cell Level Predicts ERK Inhibition Efficacy for Combinational Therapy. T. Lebedev, S. Mareeva, E. Vagapova, V. Prassolov; Cancer Cell Biology, Engelhardt Institute of Molecular Biology, Moscow, RUSSIAN FEDERATION.
12:45 pm M42 Invadopodia dynamics in prostate cancer; identification of a p-21 activated kinase 4 (PAK4) molecular pathway.. C. M. Wells1, V. Manuelli1, F. Cahill2, H. Wylie2, C. Gillett1, I. Correa1, S. Heck3, A. Rimmer1, A. Haire2, M. Van Hemelrijck1, S. Rudman1; 1School of Cancer and Pharmaceutical Sciences, Kings College London, London, UNITED KINGDOM, 2Department of Translational Oncology and Urology Research, Kings College London, London, UNITED KINGDOM, 3Institute of Diabetes Research, Helmholtz Zentrum Munchen, Munich, GERMANY.
Tuesday, December 7, 11:30 am to 1:00 pm EST
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Ori Avinoam, Weizmann Institute of Science, and Julie A. Brill, The Hospital for Sick Children, Canada
11:30 am M43 In situ structure of VPS13 family proteins. S. Cai1,2,3, X. Li4, W. Hancock-Cerutti1,2,3, J. Liu4, P. De Camilli1,2,3,5; 1Departments of Neuroscience and Cell Biology, Yale University School of Medicine, New Haven, CT, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 4Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, 5Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT.
11:45 am M44 Reconstitution of human atlastin fusion activity reveals autoinhibition by the C-terminus. D. Crosby1, M. R. Mikolaj*2, S. B. Nyenhuis*2, J. E. Hinshaw2, T. H. Lee1; 1Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 2Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD.
12:00 pm M45 Reticulons initiate the endoplasmic reticulum stress surveillance checkpoint during the cell division. M. Niwa, F. Pina; University of California, San Diego, La Jolla, CA.
12:15 pm M46 Imaging the dynamics of vesicle formation supports the flexible model of clathrin-mediated endocytosis. T. Nawara1, T. Rao1, Y. Hu2, E. Sztul1, K. Salaita2, A. Mattheyses1; 1UAB, Birmingham, AL, 2Emory, Atlanta, GA.
12:30 pm M47 Asymmetric Arp2/3-mediated actin assembly facilitates clathrin-mediated endocytosis at stalled sites in genome-edited human stem cells. M. Jin1, C. Shirazinejad1, B. Wang1, A. Yan1, J. Schöneberg2, S. Upadhyayula1, K. Xu1, D. Drubin1; 1University of California, Berkeley, Berkeley, CA, 2University of California, San Diego, San Diego, CA.
12:45 pm M48 The Effects of Class II PI3K Variants During Autophagy. I. E. Cabrera, J. Groulx, A. Kiger; Biological Sciences, UCSD, San Diego, CA.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Suzanne Marie Ponik, University of Wisconsin-Madison, and Tomeka Suber, University of Pittsburgh
*11:30 am M49 Human Viruses Rewire Membrane Contact Site Tethering Interactions, Structures, and Functions for Pro-Viral Organelle Remodeling. K. C. Cook1, E. Tsopurashvili1, J. Needham2, S. Thompson2, I. M. Cristea1; 1Molecular Biology, Princeton University, Princeton, NJ, 2University of Alabama at Birmingham, Birmingham, AL.
11:45 am M50 The Role of Keratin 16 as a Regulator of the Interferon Pathway. E. Cohen1,2, P. A. Coulombe1,2,3,4; 1Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 2Center for Plasticity and Organ Design (CPOD), University of Michigan, Ann Arbor, MI, 3Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, 4Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI.
12:00 pm M51 Tunneling nanotubes: "intercellular highways" for Ebola virus dissemination in the host. R. Titone, O. Shtanko; TEXAS Biomedical Research Institute, San Antonio, TX.
12:15 pm M52 Trex-2 Complex: A New Player in Influenza A Virus mRNA Nuclear Export. P. Bhat1, V. Akenova2, M. Gazzara3, K. Zhang1, M. Esparza1, S. Aslam4, M. Dasso2, K. Lynch3, A. Garcia-Sastre4,5,6,7, B. M. A. Fontoura1; 1Cell Biology, University of Texas-Southwestern, Dallas, TX, 2Division of Molecular and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, MD, 3Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 5Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 6Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 7The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
12:30 pm M53 Nutrition is Linked to Immunity Against Bacterial Pathogens via the NRAMP1 Metal Transporter. V. Diaz-Ochoa, K. Lokken, L. Camacho, A. Muñoz, R. Tsolis; University of California, Davis, Davis, CA.
12:45 pm M54 Fancc in control of LPS induced septic shock and bone marrow failure. S. Beesetti, R. Sumpter, D. Green; Immunology Department, St Jude Children's research Hospital, Memphis, TN.
* Cook is the graduate student recipient of the Porter Prize for Research Excellence
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Lindsay Case, MIT, and Jan Lammerding, Cornell University
11:30 am M55 Mechanical stability of Afadin-based adhesion complexes. V. T. Vachharajani, A. R. Dunn; Stanford University, Palo Alto, CA.
11:45 am M56 Programming cellular interactions and organization with synthetic cell adhesion molecules. A. J. Stevens1, A. R. Harris2, J. Gerdts1, D. A. Fletcher3, W. A. Lim1; 1University of California-San Francisco, San Francisco, CA, 2Carleton University, Ottawa, ON, CANADA, 3University of California-Berkeley, Berkeley, CA.
12:00 pm M57 Lights, Camera, Action: Investigating the activation of the Rho flare tight junction repair pathway using optogenetics. S. Chumki, R. Stephenson, A. Rai, B. Hall, A. Miller; University of Michigan, Ann Arbor, MI.
12:15 pm M58 Mechanical stresses accelerate Red Blood Cell aging. A. Garcia-Herreros1, Y. Yeh2, Z. Peng3, J. Del Alamo2,1; 1Mechanical and Aerospace, University California San Diego, La Jolla, CA, 2Bioengineering, University of Washington, Seattle, WA, 3Bioengineering, University of Illinois at Chicago, Chicago, IL.
12:30 pm M59 Shaping of the C. elegans gonad by growth-induced pressure, matrix remodeling, & differential adhesion of a leader cell.. P. Agarwal1, S. Berger2, T. Shemesh3, R. Zaidel-Bar1; 1Tel Aviv University, Tel Aviv University, Israel, ISRAEL, 2ETH Zurich, Zurich, SWITZERLAND, 3Technion University, Technion University, ISRAEL.
12:45 pm M60 The mechanobiology of bacterial biofilms growing on soft substrates. A. Cont, A. Persat; EPFL, Lausanne, SWITZERLAND.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Tomohito Higashi, Fukushima Medical University, and Weihong Qiu, Oregon State University
*11:30 am M61 Single-molecule imaging of cytoplasmic dynein in vivo reveals the mechanism of motor activation and cargo capture. N. A. Tirumala1, G. Redpath2, N. Kapoor-Kaushik3, N. Ariotti3, V. Ananthanarayanan2; 1Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, INDIA, 2EMBL Australia Node in Single Molecule Science, University of New South Wales, Sydney, AUSTRALIA, 3Electron Microscopy Unit, University of New South Wales, Sydney, AUSTRALIA.
11:45 am M62 Cephalopod RNA Recoding Sites Modulate Dynein and Kinesin Function. K. J. Rangan1,2, S. L. Reck-Peterson1,2; 1CMM and Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 2Howard Hughes Medical Institute, Chevy Chase, MD.
12:00 pm M63 A single-stranded DNA based high-throughput force sensor for molecular motors. S. Shukla1, A. Troitskaia2, N. Swarna2, B. K. Maity2, M. Tjioe2, C. S. Bookwalter3, K. M. Trybus3, Y. R. Chemla2, P. R. Selvin2; 1University of Washington, Seattle, WA, 2University of Illinois at Urbana-Champaign, Urbana, IL, 3University of Vermont, Burlington, VT.
12:15 pm M64 Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding. A. L. Solon1, Z. Tan2,3, K. L. Schutt4, L. Jepsen5, S. E. Haynes6, A. I. Nesvizhskii6,7, D. Sept5, J. Stumpff4, R. Ohi1, M. A. Cianfrocco3,8; 1Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 2Department of Biophysics, University of Michigan, Ann Arbor, MI, 3Life Sciences Institute, University of Michigan, Ann Arbor, MI, 4Department of Molecular Physiology and Biophysics, University of Vermont, Ann Arbor, MI, 5Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 6Department of Pathology, University of Michigan, Ann Arbor, MI, 7Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 8Department of Biological Chemistry, University of Michigan, Ann Arbor, MI.
12:30 pm M65 The MAP kinase scaffold JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1. R. Celestino1, J. B. Gama1, D. J. Barbosa1, A. Rodrigues1, E. A. d'Amico2, A. X. Carvalho1, J. H. Morais-Cabral1, A. Musacchio2, R. Gassmann1; 1Institute for Research and Innovation in Health (i3S), Porto, PORTUGAL, 2Max Planck Institute of Molecular Physiology, Dortmund, GERMANY.
12:45 pm M66 Trak adaptors coordinate the recruitment and activation of dynein and kinesin to control mitochondrial transport. J. Canty, A. Hensley, A. Yildiz; University of California, Berkeley, Berkeley, CA.
* Ananthanarayanan is the WICB Junior Award for Excellence in Research.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Sunil Laxman, Institute for Stem Cell Science and Regenerative Medicine (inStem), India, and Wilhelm Palm, German Cancer Research Center (DKFZ)
11:30 am M67 Subcellular localization of mTOR mRNA in neuronal growth control. N. Samra1, P. K. Sahoo2, A. Di-Pizio1, I. Rishal1, C. Buchanan2, H. Reisin-Tzur1, J. A. Oses-Prieto3, O. Abraham1, L. Marvaldi1, N. Okladnikov1, S. Ben-Dor4, R. Haffner-Krausz5, M. Terenzio6, A. L. Burlingame3, J. L. Twiss2, M. Fainzilber1; 1Biomolecular Sciences, Weizmann Institute of Science, Rehovot, ISRAEL, 2Biology, University of South Carolina, Columbia, SC, 3Pharmaceutical Chemistry, University of California, San Francisco, CA, 4Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, ISRAEL, 5Veterinary Resources, Weizmann Institute of Science, Rehovot, ISRAEL, 6Molecular Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, JAPAN.
11:45 am M68 Spatiotemporal regulation of AMPK revealed by a sensitive kinase activity reporter. D. L. Schmitt1, S. D. Curtis2, A. Leung1, J. Zhang1, M. Chen1, C. Y. He1, S. Mehta1, P. Rangamani1, R. J. Shaw2, J. Zhang1; 1University of California, San Diego, La Jolla, CA, 2Salk Institute, La Jolla, CA.
12:00 pm M69 The amino acid sensor General Control Non-derepressible 2 (GCN2) suppresses TOP mRNA translation via La related Protein 1. Z. Farooq1, N. Tabatabaei1, J. Class2, P. Toboz1, J. M. Richner2, S. Tahmasebi1; 1Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 2Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL.
12:15 pm M70 Metabolic crosstalk in the skin: how adipocytes and immune cells communicate in the wound bed. M. Forni1, Y. Xu1, W. Krause1, R. Pannone1, V. Horsley2; 1Yale University, New Haven, CT, 2Yale University, New haven, CT.
12:30 pm M71 The lysosomal enzyme trafficking factor LYSET enables cancer cells to feed on extracellular proteins. C. Pechincha1, M. de Almeida2, S. Groessl1, J. Zuber2, W. Palm1; 1German Cancer Research Center, Heidelberg, GERMANY, 2Research Institute of Molecular Pathology, Vienna, AUSTRIA.
12:45 pm M72 Environmental nutrients alter SREBP-mediated lipid metabolism in pancreatic cancer cells. P. B. Jonker, A. Muir; Committee on Cancer Biology, University of Chicago, Chicago, IL.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Binyam Mogessie, University of Bristol, UK and Yale University, and Fede Pelisch, University of Dundee, UK
11:30 am M73 Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse. A. I. Mihajlović, J. Haverfield, G. FitzHarris; Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 900 Rue St Denis, H2X0A9, Montréal, QC, CANADA.
11:45 am M74 Opposing Effects of Tubulin Isotypes on Spindle Function During Yeast Mitosis. E. Nsamba, M. Gupta; Genetics Development and Cell Biology, Iowa State University, Ames, IA.
12:00 pm M75 Unique midbody structure in mouse oocytes is associated with asymmetric cytokinesis. G. Jung, K. Schindler; Rutgers University, New Brunswick, NJ.
12:15 pm M76 Pathogenic Mutations in the Chromokinesin KIF22 Disrupt Anaphase Chromosome Segregation. A. F. Thompson1, P. R. Blackburn2,3, J. B. Lian1, E. W. Klee3, J. K. Stumpff1; 1University of Vermont, Burlington, VT, 2St. Jude Children's Research Hospital, Memphis, TN, 3Mayo Clinic, Rochester, MN.
12:30 pm M77 Kinetochore-microtubule detachment is independent of depolymerization for powering poleward chromosome movement. M. K. Parks, D. A. Compton; Dartmouth College, Hanover, NH.
12:45 pm M78 Augmin regulates kinetochore tension and mitotic fidelity by nucleating bridging fibers. V. Stimac, I. Koprivec, M. Manenica, J. Simunic, I. M. Tolic; Division of Molecular Biology, Rudjer Boskovic Institute, Zagreb, CROATIA.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Ginger Hunter, Clarkson University, and Daniel Rios, Universidad Nacional Autonoma de Mexico
11:30 am M79 Dissecting the role of the Par6/aPKC polarity complex in epithelial tissue architecture with optogenetics. M. Osswald1,2, A. Barros-Carvalho1,2, A. M. Carmo1,2, N. Loyer3, P. Grácio4, C. Sunkel1,2, C. C. Homem4, J. Januschke3, E. Morais-de-Sá1,2; 1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, PORTUGAL, 2Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, PORTUGAL, 3School of Life Sciences, University of Dundee, Dundee, UNITED KINGDOM, 4iNOVA4Health, CEDOC, NOVA Medical School, NMS, Universidade Nova de Lisboa, Lisbon, PORTUGAL.
11:45 am M80 Sarcalumenin regulates myoblast-myotube fusion via modulating calcium homeostasis between ER and cytosol. S. Sinha1, G. Zarfati1, T. Eigler2, E. Tzahor2, O. Avinoam1; 1Department of Biomolecular Sciences, Weizmann Inst Science, Rehovot, ISRAEL, 2Department of Molecular Cell Biology, Weizmann Inst Science, Rehovot, ISRAEL.
*12:00 pm M81 A sub-apical network of non-muscle myosin 2C constrains cell- and tissue-scale morphology in the intestinal epithelium. C. R. Chinowsky, M. J. Tyska; Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
12:15 pm M82 The cofilin regulator LIM-kinase controls actin dynamics during embryonic wound closure. A. M. Carmo, R. Fernandez-Gonzalez; BME, University of Toronto, Toronto, ON, CANADA.
12:30 pm M83 Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. H. Harn1,2, S. Wang1,2, Y. Lai3, B. Van Handel4, Y. Liang5,3, S. Tsai6, I. Maria Schiessl7, A. Sarkar4, H. Xi8, M. Hughes2, S. Kaemmer9, M. Tang2, J. Peti-Peterdi7, A. D. Pyle8, T. E. Woolley10, D. Evseenko4, T. Jiang5, C. Chuong5; 1University of Southern California, Los Angeles, CA, 2International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, TAIWAN, 3Integrative Stem Cell Center, China Medical University, Taichung, TAIWAN, 4Department of Orthopaedic Surgery, University of Southern California, Los Angeles, CA, 5Department of Pathology, University of Southern California, Los Angeles, CA, 6Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, 7Department of Physiology and Neuroscience, University of Southern California, Los Angeles, CA, 8Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 9Park Systems Inc., Santa Clara, CA, 10Cardiff School of Mathematics, Cardiff University, Cardiff, UNITED KINGDOM.
12:45 pm M84 Building the muscular wall in the atrial chamber of the heart involves cell elongation and reorganization of tissue polarity. M. Albu1, F. Gunawan1, R. Priya2, D. Y. R. Stainier1; 1Max Planck Institute for Heart and Lung Research, Bad Nauheim, GERMANY, 2The Francis Crick Institute, London, UNITED KINGDOM.
* Chinowsky is the MBoC Paper of the Year Awardee
Thursday, December 9, 11:30 am to 1:00 pm EST
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Gautam Dey, European Molecular Biology Laboratory (EMBL), and Masayuki Onishi, Duke University
11:30 am M85 Molecular and anatomical transformations in cilia and centrosomes underlie ciliary retraction during cerebellar granule cell differentiation. C. Ott1, S. Constable2, A. Lemire1, A. Lim3, T. Nguyen4, W. Lee4, J. Lippincott-Schwartz1, S. Mukhopadhyay2; 1Janelia Research Campus, Ashburn, VA, 2UT Southwestern Medical Center, Dallas, TX, 3Wellesley College, Wellesley, MA, 4Harvard Medical School, Boston, MA.
11:45 am M86 A unicellular walker controlled by a microtubule-based finite state machine. B. T. Larson1, J. Garbus2, J. B. Pollack2, W. F. Marshall1; 1University of California, San Francisco, CA, 2Brandeis University, Waltham, MA.
12:00 pm M87 Non-centrosomal microtubule assembly at division site regulates actin-independentcleavage-furrow formation in Chlamydomonas. N. Tajima-Shirasaki1, F. Tulin2, J. E. Little3, M. Onishi1; 1Department of Biology, Duke University - Durham, NC, Durham, NC, 2Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, 3Stanford Summer Research Program Fellow, Gunn High School, Palo Alto, CA.
12:15 pm M88 A cryptic, bacteria-dependent collective invasion in Fonticula alba reveals a new multicellularity in fungi-animal tree. C. Toret1, A. Picco1, M. Boiero-Sanders2, A. Michelot2, M. Kaksonen1; 1Biochemistry Department, University of Geneva, Geneva, SWITZERLAND, 2CNRS, IBDM, Turing Centre for Living Systems, Aix Marseille Univ, Marseille, FRANCE.
12:30 pm M89 A non-canonical role for aminoacyl-tRNA synthetase links the actin cytoskeleton to Charcot-Marie-Tooth neuropathy. B. Ermanoska1, B. Asselbergh2, M. Petrovic-Erfurth2, S. Bervoets2, R. Leitão-Gonçalves2, T. Ooms2, L. Sun3, D. Atkinson2, E. Ydens2, S. Hosseinibarkooie4, L. Almeida-Souza5, F. P. Thomas6, I. Turnev7, B. Wirth8, X. Yang3, P. Verstreken9, V. Timmerman10, T. A. Godenschwege11, A. A. Rodal1, B. L. Goode1, A. Jordanova2; 1Department of Biology, Brandeis University, Waltham, MA, 2Center for Molecular Neurology, VIB/University of Antwerp, Antwerp, BELGIUM, 3Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 4Center for Molecular Medicine, University of Cologne, Cologne, GERMANY, 5Institute of Biotechnology, University of Helsinki, Helsinki, FINLAND, 6Department of Neurology, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, NJ, 7Department of Neurology, Medical University-Sofia, Sofia, BULGARIA, 8Center for Molecular Medicine, University of Cologne, Cologne, MA, 9Center for Brain and Disease Research, VIB/KU Leuven, Leuven, BELGIUM, 10University of Antwerp, Antwerp, BELGIUM, 11Department of Biological Sciences, Florida Atlantic University, Jupiter, FL.
12:45 pm M90 Naegleria mitotic spindles are built from unique tubulins and highlight core spindle features. K. B. Velle1, M. Trupinic2, A. Ivec3, A. J. M. Swafford1, A. S. Kennard1, E. Nolton1, L. M. Rice4, I. M. Tolic2, L. K. Fritz-Laylin1, P. Wadsworth1; 1Biology, University of Massachusetts, Amherst, Amherst, MA, 2Division of Molecular Biology, Ruder Boskovic Institute, Zagreb, CROATIA, 3Department of Physics, Faculty of Science, University of Zagreb, Zagreb, CROATIA, 4Departments of Biophysics and Biochemistry, UT Southwestern Medical Center, Dallas, TX.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Sonya Neal, University of California, San Diego, and Nava Segev, University of Illinois at Chicago
11:30 am M91 Fluorogen Activating Proteins as a powerful new imaging tool for quantitative protein trafficking studies in yeast. N. A. Hager1, C. K. McAtee1, J. A. Warnick1, M. Bruchez2, J. L. Brodsky1, A. F. O'Donnell1; 1University of Pittsburgh, Pittsburgh, PA, 2Carnegie Mellon University, Pittsburgh, PA.
11:45 am M92 In vitro Reconstitution of Membrane Curvature Sensing in Autophagy. L. E. Jensen1, C. Chang1, D. Fracchiolla2, A. K. Cada1, S. Martens2, J. H. Hurley1; 1Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, 2Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Vienna, AUSTRIA.
12:00 pm M93 A cell-based GEF assay reveals new substrates for DENN domains and cooperativity between Rab and Rho GTPases in the repressor pathway of primary ciliogenesis. R. Kumar, V. Francis, G. Kulasekaran, G. Armstrong, P. McPherson; Neurology and Neurosurgery, McGill University, Montreal, QC, CANADA.
12:15 pm M94 Rabip4 isoforms bind Arl8b and regulate retrograde transport of CI-M6PR to maintain lysosomal homeostasis. S. Rawat1, R. Marwaha2, G. Charak1, G. Kumar3, S. Shaw1, D. Khatter1, S. Sharma3, C. Heus4, N. Liv4, J. Klumperman4, A. Tuli3, M. Sharma1; 1Indian Institute of Science Education and Research, Mohali, INDIA, 2Tata Institute of Fundamental Research, Hyderabad, INDIA, 3CSIR-Institute of Microbial Technology, Chandigarh, INDIA, 4University Medical Center, Utrecht, NETHERLANDS.
12:30 pm M95 Mice lacking the BORCS5 subunit of BORC show impaired axonal lysosome transport and neonatal lethality. R. De Pace; NIH/NICHD, Bethesda, MD.
12:45 pm M96 Huntingtin and Rab7 co-migrate retrogradely on a signaling late endosome during axonal injury: A novel role for Huntingtin. T. J. Krzystek, J. A. White, L. Thurston, H. Hoffmar-Glennon, Y. Li, S. Gunawardena; SUNY-Buffalo, Buffalo, NY.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Keren Lasker, The Scripps Research Institute, and Michelle Peckham, University of Leeds, UK
11:30 am M97 Chromatin and lamins A, B, and C perturbations differentially affect nuclear shape, rupture, and function. J. Collado1, M. Pho1, M. Currey1, K. Chiu1, A. Padam1, A. Gunda1, A. Lavallee1, E. Banigan2, A. Vahabikashi3, S. Sivagurunathan3, L. Almassalha4, V. Backman4, K. Reddy5, S. Adam3, R. Goldman3, A. D. Stephens1; 1Biology Department, University of Massachusetts Amherst, Amherst, MA, 2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MA, 3Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Department of Biomedical Engineering, Northwestern University, Evanston, IL, 5Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD.
11:45 am M98 Upregulation of Lamin B Receptor Drives Nuclear Envelope Fragility in Metastatic Melanoma. M. A. Baird1,2, A. X. Cartagena-Rivera3, C. Jewett4, M. Pirooznia1, R. S. Fischer1, C. M. Waterman1; 1National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 2University of Maryland, College Park, MD, 3National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, 4Johns Hopkins University, Baltimore, MD.
12:00 pm M99 Age-dependent Nuclear Lamina Remodeling Induces Cardiac Dysfunction via Misregulation of Cardiac Transcriptional Programs. N. J. Kirkland1, A. J. Whitehead1, J. D. Hocker1, P. Beri1, G. Vogler2, B. Hum2, B. Ren1,3, R. Bodmer2, A. Engler1; 1University of California, San Diego, La Jolla, CA, 2Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 3Ludwig Institute for Cancer Research, La Jolla, CA.
12:15 pm M100 Non-local mechanical feedback functions as an important input for myosin recruitment during Drosophila germ-band extension. H. J. Gustafson1, N. Claussen2, S. J. Streichan1,2; 1Biomolecular Sciences and Engineering, UCSB, Santa Barbara, CA, 2Department of Physics, UCSB, Santa Barbara, CA.
12:30 pm M101 Tuning cellular contractility by assembly of subcellular actomyosin structures. W. Chou1,2, M. Molaei3, H. Wu4, J. Beach4, P. Oakes4, M. L. Gardel3,2,5,6; 1Graduate Program in Biophysical Sciences, The University of Chicago, Chicago, IL, 2Institute of Biophysical Dynamics, The University of Chicago, Chicago, IL, 3Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 4Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, 5James Franck Institute, The University of Chicago, Chicago, IL, 6Department of Physics, The University of Chicago, Chicago, IL.
12:45 pm M102 Building Membraneless Organelles to Control Cell Behavior. M. V. Garabedian1, W. Wang2, J. B. Dabdoub1, M. Tong1, R. M. Caldwell1, W. Benman1, B. S. Schuster3, A. Deiters4, M. C. Good5; 1Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, 3Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 4Chemistry, University of Pittsburgh, Pittsburgh, PA, 5Cell and Developmental Biology, Bioengineering, University of Pennsylvania, Philadelphia, PA.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Aaron F. Straight, Stanford University, and Dileep Varma, Northwestern University Feinberg School of Medicine
11:30 am M103 Nucleolar homeostasis connects with nuclear organization. C. Wang1, H. Ma2, S. Sondalle33, S. Baserga4, T. Pederson5, S. Huang1; 1Cell and Developmental Biology, Northwestern University Feinberg Sch Med, Chicago, IL, 2School of Life Science and Technology, Shanghai Tech University, Shanghai, CHINA, 3Department of Genetics, Yale University, New Haven, CT, 4Department of Genetics, Department of Molecular Biophysics and Biochemistry, Department of Therapeut, Yale School of Medicine, New Haven, CT, 5Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA.
11:45 am M104 Cenp-b-mediated dna loops regulate activity and stability of human centromeres. F. Chardon1, A. Japaridze2, H. Witt3, L. Velikovsky1, C. Chakraborty1, T. Wilhelm1, M. Dumont1, W. Yang2, C. Kikuti1, G. Wuite3, C. Dekker2, D. Fachinetti1; 1Institut Curie, Paris, FRANCE, 2Delft University of Technology, Delft, NETHERLANDS, 3Vrije Universiteit Amsterdam, Amsterdam, NETHERLANDS.
12:00 pm M105 How does the C-terminus of the Synaptonemal Complex Protein SYP-4 regulate Crossover Formation during C. elegans Meiosis?. A. R. Neves1,2, S. Koehler1; 1Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, GERMANY, 2Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg, GERMANY.
12:15 pm M106 Nuclear accumulation of CHMP7 initiates nuclear pore complex injury in familial and sporadic ALS. A. Coyne, J. Rothstein; Johns Hopkins University, Baltimore, MD.
12:30 pm M107 Identifying the role of centromeric island in centromere function using genome editing. P. Tandale, B. Mellone; University of Connecticut, Storrs, CT.
12:45 pm M108 Ewsr1 (ewing sarcoma breakpoint region 1) facilitates cenp-a maintenance at the centromere. K. Kitagawa; Department of Molecular Medicine, Greehey Childrens Cancer Research Institute, UT Health San Antonio, San Antonio, TX.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Breann Brown, Vanderbilt University, and Danfeng Cai, Johns Hopkins Bloomberg School of Public Health
11:30 am M109 Identifying the role of septins in mitochondrial fission. R. Shannon, P. K. Kim, W. S. Trimble; University of Toronto & Hospital for Sick Children, Toronto, ON, CANADA.
11:45 am M110 Ndc1 is a dynamic membrane adaptor necessary for assembly of nuclear pores after mitosis in C. elegans. M. Mauro1, G. Celma1, V. Zimyanin2, K. Gibson3, S. Redemann4, S. Bahmanyar1; 1Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 2Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA, 3Center for Cellular and Molecular Imaging: Electron Microscopy, Yale University, New Haven, CT, 4Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA.
12:00 pm M111 Mapping and quantifying inter-organelle interactions using Soft X-ray Tomography. V. Loconte1, J. Singla2, A. Li3, J. Chen1, A. Ekman1, G. McDermott1, A. Sali1, K. White2, C. Larabell1; 1University of California, San Francisco, San Francisco, CA, 2University of Southern California, Los Angeles, CA, 3iHuman Institute, ShanghaiTech University, Shanghai, CHINA.
12:15 pm M112 A mitotic chromatin phase transition renders chromosomes microtubule-impermeable. M. W. G. Schneider1, B. A. Gibson2, S. Otsuka3, M. F. D. Spicer1, M. Petrovic1, C. Blaukopf1, C. C. H. Langer1, L. K. Doolittle2, M. K. Rosen2, D. W. Gerlich1; 1Daniel Gerlich lab, IMBA - Institute of Molecular Biotechnology, Vienna, AUSTRIA, 2Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 3Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, Vienna BioCenter (VBC), Vienna, AUSTRIA.
12:30 pm M113 Liquid-crystalline phase transitions within lipid droplets can selectively remodel the LD proteome. M. Henne; Cell Biology, UT Southwestern Medical Center, Dallas, TX.
12:45 pm M114 The C. elegans homolog of Nucleolin, NUCL-1, contributes to nucleolar organization through its intrinsically disordered RG/RGG repeat domain. E. L. Spaulding, A. Feidler, L. Cook, D. L. Updike; Mount Desert Island Biological Laboratory, Bar Harbor, ME.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Dorothy Lerit, Emory University, and Jennifer Zenker, Australian Regenerative Medicine Institute (ARMI), Monash University, Australia
*11:30 am M115 Syndecan-2 expression marks hematopoietic stem cells and controls stem cell repopulating capacity. C. M. Termini1,2, A. Pang2, M. Li1, T. Fang1, V. Chang3, J. Chute2; 1University of California, Los Angeles, Los Angeles, CA, 2Cedars Sinai Medical Center, Los Angeles, CA, 3Pediatrics, University of California, Los Angeles, Los Angeles, CA.
11:45 am M116 Tetraspanin CD82 Regulates Hematopoietic Stem and Progenitor Cell Quiescence and Regeneration. E. M. Pascetti, S. Restrepo-Cruz, M. Floren, C. A. Saito-Reis, V. D. Balise, J. M. Gillette; Pathology, University of New Mexico, Albuquerque, NM.
12:00 pm M117 Differentiation-dependent changes in Lamin B Receptor (LBR) localization influence lamin B1 dynamics and expression of differentiation markers. C. C. Wesley, D. Levy; Molecular and Cellular Life Sciences, University of Wyoming, Laramie, WY.
12:15 pm M118 Using the epithelial to mesenchymal transition (EMT) in human induced pluripotent stem cells (hiPSC) as a model to study cell states and state transitions by combining cell behavior, cell organization, and cell identity. C. Hookway, S. M. Rafelski, . Allen Institute for Cell Science; Allen Institute for Cell Science, Seattle, WA.
12:30 pm M119 Asymmetric nucleosome density and differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell fates. R. Ranjan1, J. Snedeker1, M. Wooten2, X. Chen1; 1Johns Hopkins University, Baltimore, MD, 2Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA, Seattle, WA.
12:45 pm M120 X chromosome associated histone demethylase UTX reshapes neuronal transcriptomics landscape to regulate optic nerve regeneration. S. Yang1,2, X. Wang2, C. Liu1, F. Zhou2; 1Institute of Zoology, Chinese Academy of Science, Beijing, CHINA, 2Johns Hopkins University, Baltimore, MD.
*Termini is the postdoctoral recipient of the Porter Prize for Research Excellence
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Paramita M. Ghosh, University of California Davis, and Jenifer Prosperi, Indiana University School of Medicine - South Bend and University of Notre Dame
*11:30 am M121 New features and functions of cancer lysosomes. R. M. Perera; University of California, San Francisco, San Francisco, CA.
11:45 am M122 Egf-targeted toxin as efficient anti-bladder cancer agent able to circumvent the presence of egfr endocytosis-impairing mutations and her2 in vitro and in vivo. S. Subramanian1, A. Arias-Arellano1, S. Jack1, D. Knapp2, T. Ratliff2, R. C. Aguilar1; 1Biological Sciences, Purdue University, West Lafayette, IN, 2Purdue University, West Lafayette, IN.
12:00 pm M123 Cancer-associated somatic mutations alter allosteric regulation of human phosphofructokinase-1. M. A. Voronkova, M. P. Cooper, W. J. Geldenhuys, A. R. Robart, B. A. Webb; West Virginia University, Morgantown, WV.
12:15 pm M124 Arhgap17, a Cdc42-specific gap, localizes to invadopodia and regulates their turnover as part of an Arhgap17/Cdc42/CIP4 complex. G. Kreider-Letterman1, A. Castillo1, E. K. Mahlandt2, J. Goedhart2, S. Goicoechea1, R. Garcia-Mata1; 1Department of Biological Sciences, University of Toledo, Toledo, OH, 2Section Molecular Cytology, University of Amsterdam, Amsterdam, NETHERLANDS.
12:30 pm M125 Tumor microenvironment remodeling by cancer cells-released tracks on type I collagen. L. Normand1, L. Royer1, s. Di Tommaso2,3, N. Allain1, C. Dourthe2, A. Raymond1,3, J. Dupuy4, N. Dugot-Senant2,3, A. Favereaux5, V. Moreau1, M. Ros1, F. Saltel1,3; 1Bariton U1053, Inserm, Bordeaux, FRANCE, 2Inserm, Bordeaux, FRANCE, 3TBMcore UMS 005, Bordeaux, FRANCE, 4Proteome Platform, Bordeaux university, Bordeaux, FRANCE, 5IINS, UMR 5297, CNRS, Bordeaux, FRANCE.
12:45 pm M126 Introducing genetically modified fibroblasts to tumor microenvironment for stalling cancer progression. W. Jung, Y. Chen; Mechanical Engineering, Johns Hopkins University, Baltimore, MD.
* Rushika Perera is the Gunter Blobel Early Career Awardee.
Friday, December 10, 11:30 am to 1:00 pm EST
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Siddhartha S. Jana, Indian Association for the Cultivation of Science, Kolkata, India, and Alvaro Sagasti, University of California, Los Angeles
11:30 am M127 Tunneling Nanotubes Depend Upon Network Shifts Away from Branched Actin Formation to Promote Their Uniquely Long Growth. J. M. Henderson1,2, N. Ljubojevic2,3, T. Chaze4, Q. Giai Gianetto4,5, S. Descroix1,6, P. Bassereau1, C. Zurzolo2; 1Laboratoire Physico-Chimie Curie, CNRS UMR168, Institut Curie, Paris, FRANCE, 2Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et Infection, Institut Pasteur, Paris, FRANCE, 3Sorbonne Université, Paris, FRANCE, 4Plateforme Protéomique, Département de Biologie Structurale et Chimie, CNRS USR2000, Institut Pasteur, Paris, FRANCE, 5Hub de Bioinformatique et Biostatistique, Département de Biologie Computationnelle, CNRS USR3756, Institut Pasteur, Paris, FRANCE, 6Institut Pierre-Gilles de Gennes, Paris, FRANCE.
11:45 am M128 Protrusion growth driven by myosin-generated force. G. N. Fitz, M. Weck, O. Feehan-Nelson, M. J. Tyska; Vanderbilt University, Nashville, TN.
12:00 pm M129 Macrophage cortical actin counteracts tissue resistance. V. Belyaeva1, S. Wachner1, A. Gyoergy1, S. Emtenani1, M. Akhmanova1, I. Gridchyn1, M. Linder2, M. Sibilia2, D. Siekhaus1; 1Inst Science and Technology Austria, Klosterneuburg, AUSTRIA, 2Institute of Cancer Research, Medical University Vienna, Vienna, AUSTRIA.
12:15 pm M130 A Local Ca2+ and RhoA Signaling Crosstalk Facilitates Cell Migration by Reinforcing Actin Network in the Lamellipodia. E. Iu, A. Bogatch, S. Plotnikov; Cell and Systems Biology, University of Toronto, Toronto, ON, CANADA.
12:30 pm M131 Actomyosin ring architecture during cell wound repair requires the coordinated action of linear and branched actin nucleation factors. J. Hui, M. Nakamura, S. M. Parkhurst; Fred Hutchinson Cancer Research Center, Seattle, WA.
12:45 pm M132 Rho GTPase Signaling Dynamics in Migrating and Stationary Cells. I. Ghoshal, S. Marshall-Burghardt, A. Hayer; Biology, McGill University, Montreal, QC, CANADA.
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Shermali D. Gunawardena, SUNY-Buffalo, and Peri Kurshan, Albert Einstein College of Medicine
11:30 am M133 Neuronal polarity requires an endocytic clearance mechanism in the axon initial segment. K. Eichel, T. Uenaka, S. Cheng, J. Pak, C. Taylor, M. Wernig, E. Özkan; Stanford University, Stanford, CA.
11:45 am M134 Chemico-genetic Discovery of Inhibitory Synaptic Protein PhosphorylationIn Vivo. A. M. Purkey1, E. Soderblom2, S. Soderling1; 1Department of Cell Biology, Duke University, Durham, NC, 2Duke Proteomics and Metabolomics Shared Resource and Duke Center for Genomic and Computational Biolo, Duke University, Durham, NC.
12:00 pm M135 Neurexin localization and presynaptic assembly functions are mediated by intracellular interactions. E. B. Frankel, P. S. Henry, A. Tiroumalechetty, J. Rogow, P. Kurshan; Dept. of Neuroscience, Albert Einstein College of Medicine, Bronx, NY.
12:15 pm M136 The role of βII-spectrin in cerebellar circuitry. R. Edwards1, M. Kasten2, D. Ajit1, P. Manis3, D. Lorenzo4; 1Cell Biology & Physiology, University of North Carolina At Chapel Hill, Chapel Hill, NC, 2Department of Otolaryngology, University of North Carolina At Chapel Hill, Chapel Hill, NC, 3Cell Biology & Physiology; Department of Otolaryngology, University of North Carolina At Chapel Hill, Chapel Hill, NC, 4Cell Biology & Physiology; Neuroscience Center, University of North Carolina At Chapel Hill, Chapel Hill, NC.
12:30 pm M137 Role of ER architecture in regulating synaptic properties in Drosophila motor neurons. J. Pérez-Moreno1, R. Smith1, M. K. Oliva1, K. Chahwala1, L. Zhao1, B. Yalçın1, N. Nasiboulin1, N. Jeyapalan1, V. Baena2, M. Terasaki2, C. J. O'Kane1; 1Department of Genetics, University of Cambridge, Cambridge, UNITED KINGDOM, 2University of Connecticut Health Center, Farmington, CT.
12:45 pm M138 Inpp5k and Atlastin-1 maintain the non-uniform distribution of endoplasmic reticulum-plasma membrane contacts in neuron. J. Sun*, R. Harion*, T. Naito, Y. Saheki; Nanyang Technological University, Singapore, SINGAPORE.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Saikat Mukhopadhyay, University of Texas Southwestern Medical Center, and Kandice Tanner, National Cancer Institute, NIH
11:30 am M139 Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury. D. Hu, J. Yun, J. Elstrott, H. Jasper; Genentech, South San Francisco, CA.
11:45 am M140 Crosstalk Between DBL-1/BMP Signaling and Cuticle Collagen Genes in C. elegans Body Size Regulation. U. Madaan1, E. Rezaei2, H. Reich3, P. Kayastha3, A. Chowdhury3, M. B. Goodman2, C. Savage-Dunn1; 1Queens College and the Graduate Center, CUNY, Flushing, NY, 2Stanford University, Stanford, CA, 3Queens College, CUNY, Flushing, NY.
12:00 pm M141 Piezo ensures robust tissue size regulation by balancing proliferation, cell size, anisotropy and cell death. N. Kumar, M. Levis, M. Sahir Mim, M. Unger, J. Zartman; University of Notre Dame, Notre Dame, IN.
*12:15 pm M142 Identification and functional characterization of rare post-mitotic cell states induced by injury and required for whole-body regeneration in Schmidtea mediterranea. B. W. Benham-Pyle1,2, C. E. Brewster1, A. M. Kent1, F. G. Mann, Jr.1,2, S. Chen1, A. R. Scott1, A. C. Box1, A. Sánchez Alvarado1,2; 1Stowers Institute for Medical Research, Kansas City, MO, 2Howard Hughes Medical Institute, Kansas City, MO.
12:30 pm M143 Airgel: a tissue-engineered airway for the investigation of respiratory infections . T. Rossy, T. Distler, A. Persat; Global Health Institute and Institute of Bioengineering, Ecole Polytechnique Fédérale De Lausanne, Lausanne, SWITZERLAND.
12:45 pm M144 Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology. M. Hammer, A. Lim, O. Sirenko; Molecular Devices, San Jose, CA.
*Benham-Pyle is the Merton Bernfield Awardee
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Anna Greka, Harvard Medical School / Brigham and Women's Hospital / Broad Institute of MIT and Harvard, and James Olzmann, University of California, Berkeley and Chan Zuckerberg Biohub
11:30 am M145 Unraveling Fundamental Mechanisms of Uromodulin Quality Control and Their Role in Uromodulin-associated Chronic Kidney Disease. S. Bazua-Valenti1,2, E. H. Sidhom1,2, M. Dvela-Levitt1,2, V. Padovano1, J. Roignot1, E. Grinkevich1, K. Keller1,2, C. Arevalo1, M. Racette1, E. Reyes-Bricio1, S. Vaca1, M. Papanastasiou1, N. Udeshi1, S. Carr1, A. Weins2,3, N. Himmerkus4, M. Bleich4, K. Mutig5, S. Bachmann5, J. L. Marshall1, J. L. Shaw1, J. L. Pablo1, M. Kost-Alimova1, A. Greka1,2; 1Broad Institute of MIT and Harvard, Cambridge, MA, 2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 3Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 4Department of Physiology, Christian-Albrechts-Universität, Kiel, GERMANY, 5Department of Anatomy, Charité-Universitätsmedizin, Berlin, GERMANY.
11:45 am M146 Clogging the Drain: Investigating the Capacity of Selective Autophagy in Zellweger Spectrum Disorder. K. Germain1,2, R. Bandsma3,4, P. K. Kim1,2; 1Cell Biology, The Hospital for Sick Children, Toronto, ON, CANADA, 2Biochemistry, University of Toronto, Toronto, ON, CANADA, 3Translational Medicine, The Hospital for Sick Children, Toronto, ON, CANADA, 4Nutritional Sciences, University of Toronto, Toronto, ON, CANADA.
12:00 pm M147 Mitochondrial ROS signaling enables repair of injured cells and its disruption contributes to disease onset in LGMD2B. M. Hogarth1, D. Bittel1, A. Horn1, H. Abeyratne-Perera1, A. Malatras2, W. Duddy2, A. Panigrahi1, K. Brown1, T. Partridge1, J. Jaiswal1; 1Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, 2Ulster University, Ulster, UNITED KINGDOM.
12:15 pm M148 Persistent Autophagy of p62 Clients in Quiescent Cells Limits Their Future Proliferative Potential. A. Murley, K. Wickham, A. Dillin; Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.
12:30 pm M149 Ubiquitination and deubiquitination of membrane proteins. M. Mariappan, J. A. Culver; Yale University, West Haven, CT.
12:45 pm M150 Human Signal Peptidase Complex Acts as a Quality Control Enzyme for Multipass Membrane Proteins. A. Zanotti1, J. Coelho2, D. Kaylani2, G. Singh3, D. Avci4, R. Russell3, M. Lemberg1,4, M. Feige2; 1Zentrum Für Molekulare Biologie Der Universität Heidelberg, Heidelberg, GERMANY, 2Department of Chemistry and Institute for Advanced Study, Technical University of Munich, Munich, GERMANY, 3Biochemistry Center of Heidelberg University, Heidelberg, GERMANY, 4Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, GERMANY.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Hong Liu, Tulane School of Medicine, and Stefanie Redemann, University of Virginia, School of Medicine
11:30 am M151 The Ndc80 complex coordinates with dynein for the initial kinetochore-microtubule capture during early mitosis. M. A. Amin, D. Varma; Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, IL.
11:45 am M152 Coordinated poleward flux of sister kinetochore fibers drives chromosome alignment. P. Risteski1, D. Bozan2, M. Jagric1, N. Pavin2, I. M. Tolic1; 1Ruder Boskovic Institute, Zagreb, CROATIA, 2University of Zagreb, Zagreb, CROATIA.
12:00 pm M153 Nak associated protein 1 (NAP1) activates Tank binding kinase 1 (TBK1) to regulate mitosis. S. Paul1, S. A. Sarraf2, A. M. Pickrell3; 1Graduate Program in Biomedical and Veterinary Sciences, Virginia Tech, Blacksburg, VA, 2Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke,, National Institutes of Health, Bethesda, MD, 3School of Neuroscience, Virginia Tech, Blacksburg, VA.
12:15 pm M154 A mitotic stopwatch controlling G1 progression is frequently inactivated in p53-wildtype cancers. F. Meitinger, R. L. Davis, M. B. Martinez, A. K. Shiau, A. Desai, K. Oegema; Ludwig Institute for Cancer Research, San Diego, CA.
12:30 pm M155 The chromosomal passenger complex establishes chromosome biorientation via two parallel localization pathways. T. Marsoner, P. Yedavalli, C. Masnovo, S. Fink, K. Schmitzer, C. S. Campbell; Chromosome Biology, MPL, Vienna, AUSTRIA.
12:45 pm M156 Plekha5 Regulates Mitotic Progression by Promoting APC/C Localization to Microtubules. X. Cao1, A. Shami Shah1, E. J. Sanford2, M. B. Smolka2, J. M. Baskin1; 1Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 2Molecular Biology and Genetics, Cornell University, Ithaca, NY.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Peter Kent Jackson, Stanford University School of Medicine, and Malavika (Mali) Raman, Tufts University School of Medicine
11:30 am M157 Aurora kinase A proximity map reveals centriolar satellites as regulators of its ciliary function. M. Arslanhan1, N. Rauniyar2, Y. John R2, E. Fırat-Karalar1; 1Koc University, Istanbul, TURKEY, 2The Scripps Research Institute, La Jolla, CA.
11:45 am M158 Searching for Cytonemes: visualizing specialized filopodia in the developing mouse embryo. E. T. Hall1, Y. Zhang1, M. E. Dillard1, D. Stewart1, R. Wakefield2, A. Pitre2, C. Robinson2, S. Ogden1; 1Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, 2Cellular Imaging Shared Res, St. Jude Children's Research Hospital, Memphis, TN.
12:00 pm M159 Arachidonic acid is a direct allosteric activator of Smoothened ciliary trafficking. S. S. Ansari1, W. C. Wright2,3, B. M. Young2, Z. Rankovic2, T. Chen2, S. K. Ogden1; 1Department of Cell and Molecular Biology, St.Jude Children's Research Hospital, Memphis, TN, 2Department of Chemical Biology and Therapeutics, St.Jude Children's Research Hospital, Memphis, TN, 3Department of Computational Biology, St.Jude Children's Research Hospital, Memphis, TN.
12:15 pm M160 Accelerating imaging-based reverse genetics with spatial optical barcodes and deep learning. M. Schwartz, J. Soro, E. Pao, W. Graf, D. Van Valen; Biology, California Institute of Technology, Pasadena, CA.
12:30 pm M161 Furin promotes Sonic Hedgehog Signaling by Cleaving the Ligand Deployment Protein Dispatched. E. R. Cleverdon, E. T. Hall, M. Dillard, Y. Zhang, D. P. Stewart, S. Pruett-Miller, S. K. Ogden; Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN.
12:45 pm M162 Lipidated FGF induces bidirectional FGF-FGFR signaling through cytonemes. L. Du, A. Sohr, S. Roy; University of Maryland, College Park, College Park, MD.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Hawa-Racine Thiam, National Heart, Lung, and Blood Institute, NIH, and Iva Tolić, RBI, Zagreb, Croatia
11:30 am M163 Building a synthetic cell: Cell cycle robustness and hysteresis to cytoplasmic density variation. Q. Yang; University of Michigan, Ann Arbor, MI.
11:45 am M164 A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1. L. Donker1, M. Vliem1, H. Canever2, M. Gómez-González3, M. Bosch Padrós3, W. Pannekoek1, X. Trepat3, N. Borghi2, M. Gloerich1; 1Center for Molecular Medicine, UMC Utrecht, Utrecht, NETHERLANDS, 2Institut Jacques Monod, Paris, FRANCE, 3Institute for Bioengineering of Catalonia, Barcelona, SPAIN.
12:00 pm M165 Mechanical regulation of mitotic entry. M. Dantas1,2, A. Oliveira1, P. Aguiar1, H. Maiato1,3, J. G. Ferreira1,3; 1i3S, Porto, PORTUGAL, 2Instituto de Ciências Biomédicas Abel Salazar, Porto, PORTUGAL, 3Biomedicine, Faculdade de Medicina do Porto, Porto, PORTUGAL.
12:15 pm M166 Mitotic spindle architecture is formed by crosslinker-driven coarsening of a homogeneous microtubule mesh into discrete bundles. J. Matkovic1, S. Ghosh2, N. Pavin2, I. M. Tolic1; 1RBI, Zagreb, CROATIA, 2University of Zagreb, Zagreb, CROATIA.
12:30 pm M167 Mechanical regulation of cell division orientation: investigating the role of NuMA. N. Tarannum, D. Hargreaves, G. Goddard, O. Jensen, S. Woolner; University of Manchester-89047923, Manchester, UNITED KINGDOM.
12:45 pm M168 The Astrin-SKAP Complex Lubricates the Kinetochore-Microtubule Interface. M. Rosas Salvans1, R. Sutanto1, S. Dumont1,2; 1University of California, San Francisco, san francisco, CA, 2Chan Zuckerberg Biohub, San francisco, CA.
For Minisymposia Co-Chairs:
Minisymposium Co-Chairs are responsible for reviewing abstracts, assigning talks to Minisymposia sessions, and introducing the speakers on the day of the Minisymposium. Minisymposia Co-Chairs are only eligible to speak in their session if they end up in the top scoring abstracts when scored blindly by fellow co-chairs.
A minimum of four (4) and a maximum of twelve (12) Minisymposium Co-Chairs will be selected per scientific meeting track.
Minisympsium Co-Chairs will:
- Attend a one-hour training on Diversity, Equity, and Inclusion prior to the abstract review and selection processes.
- Review and blindly score up to 150 abstracts submitted to their scientific track. The review period will take place between August 5 and August 18.
- Create a specified number of Minisymposia sessions, with help by the Program Committee Track Chairs. Each Minisymposium session will consist of six (6) talks, selected from the top-scoring abstracts.
- Chair the session at Cell Bio Virtual 2021. Co-Chairs will work together to introduce the speakers in each Minisymposium and moderate the Q&A with each of the speakers live.
Diversity and Inclusion
ASCB is committed to ensuring that a diversified and inclusive program is presented to our attendees. Minisymposia Co-Chairs will be required to ensure talks selected are from presenters with diverse ethnic, gender, and research backgrounds, career levels, and geographic locations. In order to accomplish this, the scoring will be conducted in a blind review.
Availability Requirements
Minisymposium Co-Chairs must be available during the following time periods
- Thursday, August 5 through Wednesday, August 18 - Blind Abstract Scoring Review
- Monday, August 23 through Tuesday, August 31- Selecting talks from top scoring abstracts
- Monday, December 6 through Friday, December 10 around 11:30 am EST- Available virtually on the day of Minisymposium at a designated date and time
Co-Chair Benefits
Minisymposia Co-Chairs will receive complimentary registration to the meeting. No other funds or assistance will be provided.
Timeline & Key Dates
| Co-Chair Applications | Applications for Minisymposia Co-Chairs will be accepted for consideration in organizing a Minisymposium session. | Deadline: April 20 |
| Co-Chair Review | Program Committee Track Chairs will review and score applications to select Minisymposia Co-Chairs | Late April to Late May |
| Co-Chair Notifications | Applicants will receive selection notifications. | Late May/Early June |
| Abstract Submission | Abstracts will be accepted for consideration for Minisymposium Talks. There are 6 talks in each Minisymposium. | Opens Early June; Closes August 3 |
| Abstract Review | Minisymposia Co-Chairs will review and score the abstracts and the average score will be used to determine top-scoring abstracts. | August 5 to August 18 |
| Session Scheduling | Co-Chairs and Program Committee Track Chairs will assign top-scoring abstracts to Minisymposia sessions. | August 20 to August 30 |
| Speaker Notification | Abstract submitters will receive selection notifications. | September 15 |