8:45 AM - 9:45 AM

Professional Development

Mentoring Keynote
Speaker: Margaret Werner-Washburne, University of New Mexico

10:00 AM - 11:00 AM

Professional Development

Research-based Careers in Biotechnology and Pharmaceutical Industries
Speakers: Brae Bigge, Robert Cail, Donald Gracias, Bruno da Rocha-Azevedo

10:00 AM - 12:00 PM

Special Interest Subgroups

Cell Biology at the Extremes
Presentations:

• Cell membranes of the extreme: characterizing the biosynthesis and physiological roles of membrane-spanning lipids in archaea - Andy Garcia
  
• Living with a killer: how coevolved Saccharomyces cerevisiae become killer toxin resistant - Michelle Hays
  
• Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular protist Stentor - Shashank Skekhar
  
• Cellular Transformers: Surface Glycans Mediate Robust Assembly of Silica Cages in Loricate Choanoflagellates - Deepak Krishamurthy
  
• The chytrid fungus Batrachochytrium dendrobatidis differentially regulates actin networks between its animal-like and yeast-like cell types - Sarah Prostak
  
• Extreme membrane invaginations in the largest Campylobacterota reveal novel mechanisms of bacterial cellular organization - Jean-Marie Volland

RNA Biology in Living Cells and Tissues
Presentations:

• mRNAbow: A Versatile IVT mRNA Toolkit for Multiplexed Organelle Labeling- Heejun Choi
• Cristae shaped by stochastic mRNA localization and ATP synthase oligomerization- Tatsuhisa Tsuboi
• Mitochondrial Transcription Sustains Phase Co-Existence of Mitochondrial Nucleoids and RNA Granules - Nidhi Parikh
  
• Regulation of RNA condensation by ribosomes - Stephanie Moon
• Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Sofia Quinodoz
• Investigating the Quality Control Mechanisms that Cope with Defective Ribosomal RNA - Zachary Stolp
• Direct interaction of Drosophila Vasa with the core granule protein Oskar regulates its condensation and mRNA localization - Siran Tian
• Paternal effect in early embryos - Mustafa Aydogan

Physical Biology of the Cytoplasm
Presentations:

• The role of cell ionic homeostasis in regulating cell mass density and cell membrane voltage -Sean Sun
• PKA Activity Modulates Cytoplasmic Density and Stress Resistance Through Storage Carbohydrate Production -Marina Kunzi
• Determining mechanisms underlying nuclear size control in fission yeast -Joël Lemière
• Single-molecule and super-resolution diffusivity quantification elucidates physical properties of the cytoplasm -Ke Xu
• Hag accumulation in the Bacillus subtilis cytoplasm slows Mesoscale Diffusion and limits Z-ring Condensation -Katherine Andre
• Beyond Brownian motion: Statistical complexity in cytoplasmic diffusion -Alexandros Papagiannakis
• Nuclear morphogenesis reflects both cell lineage and environmental context in 2D and 3D hiPS cell models -Leigh Harris

Cellular machines during regulation of homeostasis
Presentations:

• Probing the influences of cell state and sequence variation on the biogenesis and stability of the nuclear lamina - Abigail Buchwater
• Catching transcription factors for proteasomal degradation - Xin Gu
• Uncovering the specificity of gene expression programs in cellular quiescence and senescence - Yi Fei Tao
• How endo-lysosomal super-organelles maintain proteostasis in mammalian oocytes - Gabriele Zaffagnini
• Turning the Oxygen and Vitamin Dials - Isha Jain
• Ribosomes in Gene Regulation: Controlling the diversity of proteins made in specific cells, tissues, & organisms - Maria Barna

The Peroxisome Renaissance: From Molecular Mechanisms to Cellular Functions
Presentations:

• Peroxisome Dynamics in Arabidopsis
• Import mechanism of peroxisomal proteins with an N-terminal signal sequence
• Molecular Mechanisms of Peroxisomal Fatty-Acid Uptake
• Peroxisomal regulation of host recovery after infection
• Peroxisomes in immunity and inflammation
• How Peroxisomes keep Mitochondria Respiring

11:15 AM - 12:00 PM

Professional Development

Transitions Academy: Organizing Your Lab and Your Lab Budget
Speakers: TBD

Exhibitor Tech Talks

Bruker: Imaging of Spheroids and Organoids Using High-content Screening and Light-sheet Microscopy
Speaker: Dane Maxfield, Bruker

12:00 PM - 1:00 PM

Roundtable Discussions

Missing Half the Picture: Rethinking Women's Health in Cell Biology
Organizer: Alejandro Sanchez Pedreno Jiminez

Building Bridges, Not Islands: Having Meaningful Conversations About Science With the Public
Organizer: Jessica Sullivan

Elevating the Impact of Minority-Serving Institutions on Cell Biology Research and Education
Organizer: Jim Vigoreaux

Finding Our Flow: Connecting Neurodivergent Scientists in Academia
Organizer: Jeremiah Keyes

Fund Your Outreach Event with a Grant from COMPASS
Organizer: Ross Pedersen

Managing Uncertainty While Staying Productive
Organizer: Keren Lasker

1:00 PM - 2:30 PM

Professional Development

Special Presidential Session: The Rising Tide of Science Denial and How Cell Biologists Can Combat It
Speakers:
Kenneth Miller, Brown University
Michael Mann, University of Pennsylvania
Paul Offit, Children's Hospital of Philadelphia
Gale Sinatra, University of Southern California

1:00 PM - 3:00 PM

Special Interest Subgroups

Biological Size Control and Scaling
Presentations:

• Cell crowding drives mass density increase through changes in osmotic regulation in epithelial tissue -Heather Rizzo
• Image-enabled cell sorting identifies molecular determinants of nuclear-to-cell volume scaling -Evgeny Zatulovskiy
• Yeast growth is controlled by the proportional scaling of mRNA and ribosome concentrations -Xin Gao
• Polyploidization leads to context-dependent effects on cell growth -Matilde Galli
• AI-driven automated microscopy video analysis reveals a major origin of species-level cell cycle diversity -Kurt Schmoller
• Spatial organization and compartmentalization modulate embryonic cell cycle timing -Lendert Gelens
• CK2 modulation of the Ran pathway drives spindle morphology changes at the meiosis to mitosis transition -Helena Cantwell
• RNA Polymerase II-dependent transcriptional activity is a limiting factor for skeletal myofiber growth, size and myonuclear accretion. -Fabian Montecino-Morales

Cell Behavior and Cognition
Presentations:

• Dynamics switches in cilia coordination encode the swimming behaviors of a unicellular predator -Guillermina Ramirez-SanJuan
• A morphological circuit optimizes predatory strategy in the unicellular hunter P. collini -Scott Coyle
• Hierarchical Decision-making in Stentor -Daniel Cortes
• Decoding behavioral algorithms in cells -Ben Larson
• Decision making without central nervous systems or processors: how cells and robots navigate complex landscapes? -Yun Chen
• Multicellular collaboration: how do cells work together in the wild? -Allyson Sgro
• What is it like to be a choanoflagellate? -Thibaut Brunet

Cell Biology of Functional Condensates: Metabolons and Membrane Interfaces
Presentations:

• Multienzyme Condensates of Various Sizes Mediate Functional Crosstalk Between Glucose Metabolism and Signaling Pathways in a Size-specific Manner -Songon An
• Disrupted purinosome assembly in purine de novo synthesis disorders -Veronika Baresova
• Cytoplasmic Crowding and Diffusion Dynamics Regulate Biomolecular Condensation -Hui Li
• Primary partitioning principles of the cell: Cytoophidium assembly, phase separation and membrane enclosure -Ji-Long Liu
• Jurkat T cell activation requires raft-associated LAT condensates -Sze Ham Chan
• Nano-liquid Signal Integration Hubs Promoting Cell Survival and Growth -Akihiro Kusumi
• Lipids facilitate protein assembly at membranes through prewetting -Sarah Veatch
• Contact sites at the interface of membraneless organelles and membranes -Dragomir Milovanovic

Stress Signaling Networks and the Aging Cell
Presentations:

• Interrogating the function of the nuclear lamina using deep mutational scanning in human iPSCs -Jessica Mella
• Rational sequence design for enhanced editing specificity of RNA sensors -Jennifer Wang
• Beyond unfolded proteins and lipid stress: ER protein influx as a regulator of IRE1 activity -Diego Acosta-Alvear

Physical Biology of Infection and Immunity
Presentations:

• Chromatin organization regulates plasma membrane tension and cell integrity independently of gene expression - Aidan Cabral
• In Vitro Generated Neutrophils Reveal High Deformability is an Emergent Property - Allen Yesin
• Target cell motility dictates the phagocytic outcome by initiating a mechanical tug-of-war - Brandon Scott
• An automated imaging platform for quantitative antibody-dependent cellular phagocytosis - Valentin Jaumouillé
• Role of listeriolysin O and phospholipases C in Listeria monocytogenes intercellular protrusion dynamics, resolution, and autophagy avoidance - Stéphanie Seveau
• Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference - Kelli Hvorecny
• Molecular thresholds of CAR T cell activation - Shalini Low-Nam
• Bacteria Distinguish Between Local and Global Envelope Stress - Enrique Rojas

1:45 PM - 3:15 PM

Professional Development

Transitions Academy: Mentored Undergraduate Research Showcase
Speakers: TBD

2:45 PM - 3:30 PM

Professional Development

Early Career Women Faculty Development
Speakers: Megan King, Mary Munson, Bettina Winckler

3:30 PM - 4:00 PM

Pre-Keynote Networking

4:00 PM - 5:30 PM

Opening Keynote Session

The Evolving Cell: From Ancient Origins to Modern Defenses
Speakers:
Buzz Baum, MRC Laboratory of Molecular Biology
Zhijian "James" Chen, University of Texas Southwestern

5:30 PM - 6:45 PM

Opening Night Reception

8:30 AM - 9:45 AM

Community Building

Planetary Cell Biology
Speakers:
Amy Gladfelter, Duke University
Karla Neugebauer, Yale University
Chad Pearson, University of Colorado
Courtney Stairs, Lund University
Abbas Zaki, University of Texas Southwestern
Alexandra Worden, Marine Biological Laboratory

8:45 AM - 9:45 AM

Symposia

Multimodal Imaging and AI in Cell Biology
Speakers:
Gaia Pigino, Human Technopole
Guoqiang Bi, University of Science and Technology of China

Evolutionary Cell Biology
Speakers:
Nicole King, University of California, Berkeley
Lilian Fritz-Laylin, University of Massachusetts Amherst

9:30 AM - 12:00 PM

Professional Development

Career Coaching Sessions

10:00 AM - 10:45 AM

Professional Development

Maintaining Inclusion in Science
Speakers:
Imge Ozugergin, Institut Pasteur - Paris, France
Adam Martin, Massachusetts Institute of Technology
Erin Goley, Johns Hopkins University School of Medicine
Claire Thomas, Pennsylvania State University

10:00 AM - 12:00 PM

Minisymposia

Cell Biology of Meiosis
Presentations:

• Transcription factor Ovo orchestrates an inducible response to episodes of transposon threat in the male germline - Amelie Raz
  
• Essential roles of BRCA2 in spermatogenesis and oogenesis - Hunter Neil
  
• Real-time visualization of crossover designation in meiosis - Simone Koehler
  
• ESCRT recruitment to meiotic nuclear envelope hole - Arnav Pandey
  
• A Ring-Shaped Chromosome-Associated Protein Complex Promotes Proper Microtubule Organization in C. elegans Oocytes - Jordy Martinez
  
• Illuminating actin-driven mechanisms of chromosome segregation in mouse oocyte meiosis - Andrea Rix
• Differential contributions of β-tubulin isotypes to spindle assembly and chromosome separation dynamics during C. elegans acentrosomal oocyte meiosis - Emmanuel Nsamba
  
• DDX4 and HDLBP Regulate the Progression of Meiosis through Translational Regulation of Emi2 mRNA in Mouse Oocyte - Takahiro Sanada

Dynamics of the Actin Cytoskeleton Across Physiological States
Presentations:

• Mechanism of processive pointed-end elongation of actin filaments by Leiomodin2 - Shashank Shekhar
  
• A new family of pointed end actin regulators (Aip5/SH3BGRL) conserved between animals and fungi - Joseph Magliozzi
  
• EPS8 dampens the growth dynamics and prolongs the lifetime of actin-based protrusions - Alexandra Mulligan
  
• Cyclase Associated Actin Cytoskeleton Regulatory Protein 2 (CAP2) Organizes the Actin Cytoskeleton to Influence the Biomechanical Properties of the Ocular Lens - Sepideh Cheheltani
  
• Cofilin controls the sorting of tropomyosin to distinct actin networks - Shane McInally
  
• CAP1-driven actin filament disassembly organizes epidermal morphogenesis in vivo - Chen Luxenburg
• Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers - Tianyang Liu
• Beyond Branching: Structural Basis of Arp2/3 Complex Activation for Linear Actin Filament Nucleation by a SPIN90 Dimer - Justus Francis

Cell Biology of Organelles
Presentations:

• The ER crossing guard: Djp1 facilitates peroxisomal membrane protein trafficking - Megan Balzarini
  
• Mitochondrial presequences harbor variable strengths to maintain organellar function - Natalie Niemi
  
• A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo - Christina Gladkova
  
• Structural insights into GTP-coupled conformational changes in Mfn1 revealed by time-resolved transition metal ion FRET - Sophie Hurwitz
  
• A Sir2-dependent pathway regulates nuclear lipid droplet biogenesis - Lauren Carson
  
• Lipid Droplet-Associated Opa1 Regulates Fatty Acid Release - Xiao Li
• Mitophagy amplitude is regulated by an interplay between receptor protection and turnover - Abhishek Kumar
• VPS13C interaction with GATOR2 is required for mTORC1 activation in plasma membrane-endoplasmic reticulum contact sites - Wim Annaert

Integrative Cell and Developmental Systems Biology
Presentations:

• Aggregation and DNA binding of Dorsal/NF-κB in early embryos - Gregory Reeves
  
• Signal processing and robustness of the BMP network during zebrafish embryogenesis - Nissa Larson
  
• Reactive Oxygen Species Counteract Zebrafish Wound Contraction and Promote Wound Healing - Chang Ding
  
• Reverse engineering organ size and shape control through the integration of quantitative experiments and multi-scale computational modeling - Jeremiah Zartman
  
• Investigating cytoskeletal and cellular dynamics during morphogenesis in the zebrafish - Bakary Samasa
  
• AI-powered Acceleration and Parameter Tuning for Computational Modeling - Linlin Li

Physical Cell Biology from Molecules to Organisms
Presentations:

• Tuning the Emergent, Time and Length Scales Dependent Viscoelasticity of Biomolecular Condensates - June Ho Hwang
  
• Adhesion-Cortical Flow Coupling Drives Spinning Cytokinesis to Establish Embryonic Chirality - Yuxuan Rain Xiong
  
• Single-molecule analysis of morphogen diffusion revealed tightly regulated, dynamic morphogen-matrix interactions that shape the evolution of animal morphology - Gavin Schlissel
  
• Epigenetic Remodeling Stores Mechanical Memory and Stabilizes Gene Regulation - Rohit Joshi
  
• Limits of Cell and Nuclear Scaling in a Remodeling Epithelium - Liam Russell
  
• Contractile dampening of tissue wetting underlies embryo implantation defects in aged females - Kate Cavanaugh
• Tissue fluidity: A double-edged sword for multicellular patterning - Rikki Garner
• A self-limiting positive feedback loop ensures robust inner ear canal morphogenesis - Yusuke Mori
• Nanorobot microheology in vivo: spatiotemporal mapping of the mesenchymal tissue viscoelasticity in development - Fengtong Ji

10:15 AM - 11:00 AM

Exhibitor Tech Talks

Bruker: Advanced AFM Imaging and Analysis of Cellular and Tissue Samples: Innovations in Large-Area Mapping and Mechanobiology
Speaker: Yi Wei, Bruker

Bruker: Characterizing membrane-associated molecular interactions directly on cells using single-cell Interaction Cytometry
Speaker: Matthew Peterfreund, Bruker Biosensors

11:15 AM - 12:00 PM

Exhibitor Tech Talks

MilliporeSigma: HUB Organoid Technology: Advancing Drug Discovery and Biobank Access
Speaker: Javier Frias Aldeguer, Millipore Sigma

Oxford Instruments: Reproducible Research Made Simple: Introducing Imaris 11 Workflows
Speaker: Amelia Ralowicz-Perrone, Oxford Instruments

12:00 PM - 12:45 PM

Roundtable Discussions

Childcare in Academia: Challenges and Solutions
Organizer: Allyson O'Donnell

Closing the Digital Skills Gap in Life Sciences
Organizer: Helen Jourdain-Dawe

Meet ASCB President Mary Munson
Organizer: Mary Munson

Organizing the Nuclear Cell Biology Community
Organizers: Mary Dasso and Ross Pedersen

Postdocs and Early Career Faculty Jobs in the UK and Europe
Organizers: Laura Machesky and Robert Insall

Meet with NSF BIO Program Officers
Organizer: Matthew Buechner

12:15 PM - 1:00 PM

Exhibitor Tech Talks

Allen Institute for Cell Science: BioFile Finder (BFF): An Easy-to Use, Web-based Solution for Sharing Image Data & Increasing Transparency.
Speakers:
Caroline Hookway, PhD, Sr Scientist, Allen Institute
Gideon Dunster, PhD, Scientific Program Manager, Allen Institute

Carl Zeiss Microscopy, LLC: ZEISS Lunch and Learn: Advances in Microscopy for Cell Biology Research
Speaker: Antonio Pedrosa, PhD.

12:45 PM - 1:45 PM

12:45 PM - 2:15 PM

Professional Development

Scholarship for Transformative Change Keynote Lecture
Speaker: Bryan Dewsbury, Florida International University

Professional Development

EMBO Training: Writing an Effective Abstract and Title for Papers
Moderator: Poonam Bheda, EMBO

1:00 PM - 4:00 PM

Professional Development

Career Coaching Sessions

1:15 PM - 2:00 PM

Exhibitor Tech Talks

MilliporeSigma: CRISPR editing technologies: from knockouts to base edits
Moderator: April Bauer, MilliporeSigma
Speaker: Erin Brettman, MilliporeSigma

2:00 PM - 3:00 PM

Awards

Education Awards Session featuring:
Bruce Alberts Award for Excellence in Science Education: Janet Iwasa
Innovation in Education Award: Lara Goudsouzian

2:15 PM - 3:00 PM

Exhibitor Tech Talks

Syncell Inc.: Microscoop: Sub-Organelle Photo-Biotinylation Microscope for Protein Purification and Discovery
Speakers:
Jung-Chi Liao, Syncell Inc.
Luisa Iruela-Arispe, Northwestern University

Thermo Fisher Scientific: Modernize your Cell Culture: Save Time, Improve Consistency
Speaker: Josh DiGiacomo, Thermo Fisher Scientific

4:00 PM - 5:00 PM

Professional Development

Transitions Academy: The road to independence within and beyond academia
Speakers: TBD

4:00 PM - 5:15 PM

Scientific Sessions

Cilia Biogenesis, Structure, and Function
Presentations:

• Cilia, little organelles with big roles in development and disease - Gregory Pazour
  
• Single-molecule imaging of intraflagellar transport train assembly in C. elegans chemosensory cilia - Erwin Peterman
  
• Ciliary signaling regulates adipocyte stem cell fate - Keren Hilgendorf
• Ciliary ARL13B prevents obesity in mice - Tiffany Terry
• The DNA damage response pathway is required for multiciliated cell differentiation - Cayla Jewett
• Autoinhibition, Microtubule Bundling, and Centriole Amplification: The Surprising Biology of a Novel MAP in Multiciliated Cells - Venkatramanan Rao

Science and Art: Bridging Two Creative Universes
Presentations:

• Making Science Inclusive Through Art: The Tactile Mitosis Project - Ahna Skop
  
• Molecular Animation: Past, Present, and Future - Janet Iwasa
• Conveying Science With Art in Everyday Settings - Julia Licholai
• From Microscopes to the Masses: Turning Data into Art That Stops the Scroll - Dylan Burnette
• The (sci)art of microscopy - Nathanaël Prunet

Synthesizing Chromatin States through New Tools and Models
Presentations:

• Synthetic histone fragments to block histone chaperones - Andrew Lipchik
  
• Protein ligation tools to synthesize chromatin - Yael David
• Synthetic transcription factors for diseased cells - Graham Erwin
• Inducible Epigenome Editing Using Chemical Dimerizers - Jacob Kirkland

4:00 PM - 6:00 PM

Awards Session

Visionary Awards Session featuring:
E.B. Wilson Award: Sandra Schmid
E.E. Just Lecture: Joel Blankson
EMBO Gold Medal: David Bikard
Sandra Masur Senior Leadership Award: Kristen Verhey

5:30 PM - 6:45 PM

Scientific Sessions

AI Applications in Cell Biology
Presentations:

• Harnessing AI/ML for Quantitative Cell Biology - Margaret Gardel
  
• Geometry for cells: Analyzing microscopy images from the cell’s point of view - Meghan Driscoll
  
• Foundation Models for Spatial Biology - David Van Valen

Bench-to-Bedside and Rare Diseases
Presentations: TBD

Biophysical Modeling of the Cell
Presentations:

• Introduction to rule-based modeling. Hands-on practice with BioNetGen - James Faeder
• Graphical Rules and Spatial Rule-based Modeling. Hands-on Practice with VCell - Michael Blinov
• Simulating Macromolecular Self-assembly for Cell Biology. Hands-on Practice with NERDSS' - Margaret Johnson and Samuel Foley

Use Optogenetic Tools to Interrogate Cellular Mechanisms
Presentations:

• Foundations of Optogenetic Control of Proteins and Cells - Lukasz Bugaj
  
• Optogenetic Control of Cytosolic Protein Transport - Anna Vankeuren
• Optogenetic Control of Receptor Signaling and Growth Gone Dynamics - Siddharth Karthikeyan
• Optogenetic Control of Developmental Patterning in Live Embryos - Nathan Lord

5:30 PM - 6:30 PM

Professional Development

Careers in Life Sciences Venture Capital and Consulting (COMPASS)
Speakers: Cynthia Cai, Yi-Yen Chen, Sarah Johnson

5:30 PM - 7:00 PM

Scientific Sessions

Ancillary Session: Interfacing Cells with the Extracellular Matrix
Sponsored by HHMI Janelia Research Campus
Speakers:
Rebecca Wells, University of Pennsylvania
Kayvon Pedram, HHMI Janelia Research Campus
Valerie Weaver, University of California, San Francisco
Jiefu Li, HHMI Janelia Research Campus

8:15 AM - 9:00 AM

Exhibitor Tech Talks

Leica Microsystems Inc.: NAMs Unlocked: Visualizing Organoid Complexity Through Advanced Imaging
Speakers: Andrew Barazia, Leica Microsystems Inc.

8:30 AM - 9:45 AM

Professional Development

Bioengineering: deriving knowledge and translating findings
Speakers: TBD

8:45 AM - 9:45 AM

Symposia

Cell Biology of Organelles and the Cytoskeleton
Speakers:
Mike Rout, Rockefeller University
Amy Gladfelter, Duke University

Motility, Mechanics, and Migration
Speakers:
Jie Xiao, Johns Hopkins University
Robert Insall, University College London

9:30 AM - 12:00 PM

Professional Development

Career Coaching Sessions

10:00 AM - 10:45 AM

Professional Development

Two or More Bodies: Science While Parenting and Partnering
Speakers: Robert Cail, Binyam Mogessie, Sadie Wignall

10:00 AM - 11:30 AM

Professional Development

EMBO Training: Providing Constructive Feedback in Peer Review
Speakers: Sara Monaco, EMBO - Review Commons

10:00 AM - 12:00 PM

Minisymposia

Cell-Cycle Mechanisms and Cancer Vulnerabilities
Presentations:

• CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication - Samsara Upadhya
  
• Fluorescent cross-correlation spectroscopy reveals the affinity of cyclin–CDK complexes using green and near-infrared fluorescent proteins - Aika Toyama
  
• Phosphoproteomics identifies a new role for Cdr2 kinase in cell division - Veronica Garrido
  
• Untimely Fibrous Corona Expansion Driven by MPS1 Overexpression Underlies Chromosomal Instability in Colorectal Cancer - Ana Pinto-Teixeira
  
• Cytokinesis failure can be predicted before mitosis in mammary epithelial cells - Maryam Kohram
  
• Characterizing a Novel Class of Antimitotic Compounds - Keming Li
• Targeting cyclin-dependent kinases to overcome therapy resistance in breast cancer - Sungsoo Kim

Compartmentalized Signaling in Neurons
Presentations:

• Decoding Synaptic Signaling Dynamics Underlying Plasticity - Ryohei Yasuda
  
• Live Super-Resolution Imaging Reveals Regulated Phase Separation of Postsynaptic Proteins - Matthew Dalva
  
• A Potential Role for Par3 in Organizing the Postsynaptic Scaffold - Hanna Caiola
  
• Temporal-specific degradation of activity-induced nascent proteins by membrane-associated proteasomes in the developing visual circuit - Haiyan He
  
• Synapses drive local mitochondrial ATP synthesis to fuel plasticity - Ilika Ghosh
  
• BAI1/ADGRB1-mediated Regulation of Mitochondria Morphology in Axons - Kimberley Tolias
• Endocytic machinery maintains active zone assembly at presynaptic nerve terminals - Javier Emperador Melero
  
• Synaptojanin1 supports VPS35-dependent trafficking of dopamine D2 autoreceptors at presynaptic terminals - Pingyue Pan

Plasticity and Cross-talk Between Cytoskeletal Components
Presentations:

• Curved microtubule regions mark sites of lattice compaction in cells and neurons - Nisha Mohd Rafiq
  
• Cortical microtubule reinforcement enables mechanical resistance of actomyosin-driven contractions in C. elegans and mouse oocytes - Alyssa Quiogue
  
• Readers of a tubulin conformational code - Takashi Hotta
  
• Mechanism of APC-mediated branched actin assembly at the microtubule tip - Xingyuan Fang
  
• The Interplay Between the Tubulin- and MAP-Codes and Their Effects on Kinesin Motility - Jonathan Fernandes
  
• Septin crosstalk with microtubules and actin filaments is regulated by phosphorylation of septin 9 by the glycogen synthase kinase 3 beta - Md Noor A Alam
• A metaphase, septin-associated myosin filament cage ensures lumen integrity in intestinal organoids by promoting metaphase cell rounding and planar cell division - Sulaiman Yousafzai
  
• Structural Basis of Tubulin Post Translational Modification Recognition by EML Proteins - Aryan Taheri

Immune Cell Biology
Presentations:

• Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center - Jue Wang
  
• The functional role of localized plasma membrane scrambling in immune cell activation - Daryna Sputay
  
• Glycosylation inhibition enhances natural killer cell cytotoxicity through nanoscale reorganization of CD16a signaling and effector domains - Hijab Fatima
  
• Role of citrullinated vimentin in the pathogenesis and progression of multiple sclerosis - Lukasz Suprewicz
  
• Tropomyosin and integrin engagement cooperate to promote actomyosin arc-dependent force generation at the T cell immune synapse required for efficient target cell killing - Dillon Schrock
  
• A time limit for phagocytosis: FcRIIB triggers delayed inhibition of phagocytic cup extension - Erika Snyder
• Peroxisomes in immunity and inflammation - Francesca Di Cara
  
• Chimeric Antigen Receptor T Cells generate antigen-specific mechanical forces - Rachel Fitzgerald

Structure, Function and Mechanics of the Nuclear Envelope
Presentations:

• Rainbow Nucleus Charts Dynamic Interactome of Membrane-less Organelles - Songtao Ye
  
• An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity - Nicholas Ader
  
• Lamin-B1 maintains nuclear peripheral protein localization to promote proper genome organization and efficient cardiomyocyte differentiation during early development - Katherine Bossone
  
• Phosphoinositide Phosphatase Myotubularin (MTM1) Regulates Myonuclear Architecture and Regional Chromatin Modifications - Matthew Haemmerle
  
• Muscular dystrophy-associated lamin mutations disrupt cytoplasmic macromolecular crowding via a nucleolar-ribosome axis - Xiangyi Ding
  
• Nuclear envelope-endoplasmic reticulum junctions regulate the diffusional exchange of proteins to the nuclear envelope - Marc Goudge
• Cell confinement aftereffects include heritable loss of chromosomes and a persistently dysregulated division program - Jeneille Deans
  
• Membrane dynamics driven by the Arp2/3 complex regulate myofibers growth and myonuclear accretion during skeletal muscle postnatal development - Catarina Sequeira

10:15 AM - 11:00 AM

Exhibitor Tech Talks

Quartzy: The Operating System for the Lab: Turning Fragmented Workflows Into a High-Output Engine
Speakers: Justin Friedman, Quartzy

11:00 AM - 11:45 AM

Professional Development

Connecting Conversations
Speakers: Quyen Aoh, Gannon University; Kaitlyn Casimo, Allen Institute; and Sarah Vandal, Dartmouth College. This session is facilitated by members of ASCB's Science Communication, Outreach, and Public Engagement (SCOPE) Committee.

11:00 AM - 12:00 PM

Professional Development

Scripts of Success: Award Winning Scientists Take the Stage with Humor and Honesty
Speakers: Kamena Kostova, Kathy Schmeidler, Julie Van De Weghe

12:00 PM - 12:45 PM

Roundtable Discussions

microPublication Biology: Opportunities for Authors, Reviewers, and Educators
Organizer: Lina Dahlberg

INSPIRING the Future of Biomedical Research Through Resilience
Organizer: Juan Alvarez

Meet the members of the Women in Cell Biology (WICB) committee and discuss issues of interest to our community
Organizer: Allyson O'Donnell

From Membrane Proteins Trafficking to AI and Computational Modeling: Developing Skills for Interdisciplinary Careers
Organizer: Rinalda Proko

Strategic Collaboration Exchange: Architecting High-Impact Scientific Partnerships
Organizer: Anoop Arunagiri

Navigating Grant Funding Opportunities with NIGMS Program Directors
Organizer: Kalynda Gonzales Stokes

Meet with NSF BIO Program Officers
Organizer: Matthew Buechner

12:15 PM - 1:00 PM

Exhibitor Tech Talks

Leica Microsystems Inc.: Visualize Life in Motion — Fast, Uncompromised, and Over Time with Innovative Light Sheet Microscopy
Speakers: Judith Reddington, Leica Microsystems Inc.

12:45 PM - 1:45 PM

Professional Development

Ben Barres LGBTQ+ Diversity Session
Speaker: Bruno da Rocha-Azevedo, Eikon Therapeutics

1:00 PM - 4:00 PM

Professional Development

Career Coaching Sessions

1:15 PM - 2:00 PM

Exhibitor Tech Talks

Thermo Fisher Scientific: Advancing iPSC-Derived NK Cell Therapy: Optimizing Genome Editing and Automated Manufacturing for Enhanced Cancer Treatment
Speakers: Olga Cohen, Thermo Fisher Scientific

2:00 PM - 3:30 PM

Professional Development

Explaining Your Science Beyond the Lab
Speakers: TBD

4:00 PM - 5:00 PM

Professional Development

Elevator Pitch Contest: Show Off Your Two-Minute Speech
Facilitators: Quyen Aoh, Gannon University; Katie Coscia, Middle Tennessee State University; Mike Onken, Washington University in St. Louis; and Melanie Stegman. This session is facilitated by members of ASCB's Science Communication, Outreach, and Public Engagement (SCOPE) Committee.

4:00 PM - 5:15 PM

Scientific Sessions

Evolutionary Cell Biology
Presentations:

• Losses of Deeply Conserved Genes in the Mitotic Exit Network Led to Multiple Rewiring Events in Budding Yeasts - Xiaoxue Zhou
  
• Differential regulation of actin paralogs as a conserved mechanism of stress response - Ananya Nidamangala Srinivasa
  
• Testis-Specific Actl8 Is a Novel Nuclear Actin Related Protein That Alters Gene Expression - Nuria Cortes-Silva
• A Rapidly Evolving Protein Domain of Flightin Influences Flight Muscle Myofilament Lattice Structure, Power Output, Courtship Song Quality, and Mating Success in Drosophila - Jim Vigoreaux
• Intraprotein domain competition dictates pulsatile response of photoreceptors shaped by temperature and evolution - Zikang (Dennis) Huang
• Signaling pathways governing the trigger of regeneration in Stentor coeruleus - Connie Yan
• Organelle inheritance and scaling in a multi-budding yeast - Alison Wirshing
• Subcellular localization and expression patterns of de novo emerged microproteins - Carly Houghton

Mathematical Modeling for Cell Biology Workshop
Presentations:

• Optimizing Models of Circadian Rhythms - Pedro Mendes
  
• Spatial Modeling of Calcium Waves - Ion Moraru
• Managing Combinatorial Complexity in EGFR Signaling - Michael Blinov
• Mesoscale Modeling of Multivalent Molecular Assembly - Leslie Loew

MBoC Highlights: The Future of Cell Biology
Presentations:

• A human interpretable cell behavior grammar to democratize simulations in virtual multicellular laboratories - Paul Macklin
  
• Biological imaging across scales with reconfigurable reactive microscopes - Wesley Legant
• Tubulin glutamylation increases tau condensate diffusivity and enables kinesin motility - Antonina Roll-Mecak
• A human interpretable cell behavior grammar to democratize simulations in virtual multicellular laboratories - Elana Fertig

Spatial Proteomics Workshop
Presentations:

• Super-resolution Spatial Proteomics using FLASH-PAINT - Joerg Bewersdorf
• Where Cells Meet: Quantitative Mapping of Cellular Borders Across Scales - John Hickey
• Integrative Structural Cell Biology: When Light & Electron Microscopy Meet Subcellular Proteomics - Manuel Leonetti

Ancillary Session:
Organelle Dynamics and Multicellularity
Sponsored by the Chinese Society for Cell Biology
Speaker: Xing Liu, University of Science and Technology of China

4:15 PM - 5:15 PM

Keith R. Porter Legacy Awards Session:

Keith R. Porter Lecture: Valerie Weaver
Porter Prize for Research Excellence (Postdoc): Damian Dudka
Porter Prize for Research Excellence (Graduate): Jimmy Ly

5:30 PM - 6:30 PM

Emerging Leader Awards Session:

Gunter Blobel Early Career Award: Itay Budin
Innovation in Research Award: Shigeki Watanabe
WICB Junior Award for Research Excellence: Sarah Cohen
Merton Bernfield Memorial Award: Mikael Garabedian

5:30 PM - 6:30 PM

Professional Development

Transitions Academy: Getting into Graduate School: the Do's, the Don'ts, and the What If's
Speakers: TBD

5:30 PM - 6:45 PM

Scientific Sessions

Bacterial and Archaeal Cell Biology
Presentations:

• Biomolecular condensates as stress-responsive chemically distinct microenvironments within the bacterial cytoplasm - Seth Childers
  
• Ferries, tunnels and bridges for lipid transport across the bacterial cell envelope - Gira Bhabha
• The Biochemical and Physiological Drivers of Membrane Modifications in Thermophilic Archaea - Paula Welander

Methods to Accelerate iPSC-derived Disease Modeling and Therapeutics
Speakers: TBD

Organoids in Focus: From Physiology to Pathology and Drug Discovery
Speakers: TBD

What's Next: Cell Biology from ASCB MOSAIC Program Alumni
Presentations:

• How augmin establishes the angle of the microtubule branch site - Jodi Kraus
  
• Loss of indiscriminate GLDR-2 tailing enhances body length and reduces fertility and embryonic viability in C. elegans - Karl-Frédéric Vieux
• AAV Delivery of MET Channel Subunits (Tmc, Cib2, Tmie) Restores Hearing and Balance in KO Mice - Evan Ratzan
• The Biology of Longevity: From Energy Metabolism in the Brain to Reproductive Aging - Ewa Bomba-Warczak

5:30 PM - 7:00 PM

Scientific Sessions

Ancillary Session:
Cell Biology in Germany – an introduction to three research hubs
Sponsored by German Research Federation
Speakers:
Britta Maedge, Deutsche Forschungsgemeinschaft
Waldemar Kolanus, University of Bonn
Carien Niessen, University of Cologne
Christina Gross, University of Freiburg

8:45 AM - 9:45 AM

Symposia

Cellular Quality Control and Homeostasis
Speakers:
Christina Towers, Salk Institute
Phyllis Hanson, University of Michigan

Life in 3D
Speakers:
Minoru Takasato, Riken
Xin Sun, University of California, San Diego

8:45 AM - 9:45 AM

Professional Development

A Figure Says a 1,000 Words: Tips and Tools for Creating Standout Figures
Speaker: TBD

9:30 AM - 12:00 PM

Professional Development

Career Coaching Sessions

10:00 AM - 10:45 AM

Professional Development

Small Publications, Big Impact: microPublications as a Path to Scholarship for PUI Faculty and Their Undergraduates
Speaker: TBD

10:00 AM - 12:00 PM

Minisymposia

Advancing Vision and Change: Examining Student Identity Formation in Science Education
Presentations:

• Examining the influence of Vision & Change and a mentoring network on teaching philosophies and strategies - Michael Wolyniak
  
• Using Science Practices to Enact Vision and Change in the Introductory Biology Laboratory - Lina Dahlberg
  
• Assessing the impact of open science in classrooms on student learning outcomes and attitudes - Kaitlyn Casimo
  
• Undergraduates’ sense of belonging in science is enhanced by a curriculum on preprint peer review - Rebeccah Lijek
  
• The Council on Undergraduate Research (CUR) Biology Division: A Dynamic Community Promoting Best Practices in Undergraduate Biology Education - Michael Wolyniak

Cancer Cell Biology: Cellular Interactions in the Tumor Microenvironment
Presentations:

• ZBTB18 limits tumor cell pliancy and tumor cell-myeloid cell crosstalk to inhibit metastasis - Myriam Labelle
  
• Nuclear envelope rupture of breast cancer cells drives epigenetic and inflammatory reprogramming - Kayla Snare
  
• Adipose-Mimetic Granular Hydrogels Reveal Biophysical Cues Driving Breast Cancer Invasion - Brianna Knode
  
• Mitochondria Anchor Local Translation and Drive Metastatic Migration - Subhajit Dutta
  
• Targeting ACSS2 Induces Immunogenic Cell Death and Enhances Immune Activation in Breast Cancer Brain Metastases - Riley Young
  
• Mechanotransduction Signals from Cancer-Associated Fibroblasts Regulate Nuclear Structure and Invasive Characteristics in Cancer Cells - Christal Rolling
• Loss of actin-binding protein Profilin-1 leverages genomic instability to trigger anti-tumor immune response in breast cancer - Ian Eder

Cell Biology at Scale: New Technologies for Systematic Exploration of Cellular Biology
Presentations:

• Large-scale functional genetics approaches reveal the mechanistic basis for core cellular processes - Iain Cheeseman
  
• Cell Biology at the Scale of the Organism: Whole Body Cellular Activity Imaging in Vertebrates - Virginia Ruetten
  
• A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology - Jingbo Sun
  
• Ballistic Microscopy (BaM) - Jijumon A. S.
  
• A multiplexed approach for genetic screening of human cells by electron microscopy uncovers an intermembrane space protein impacting mitochondrial cristae-shape - Sarah Hassdenteufel
  
• Ribosome demographics link molecular aging to chronological aging - Jordy Botello
• Toward a software ecosystem for subcellular proteomics - Duo Peng
• Toward understanding cellular dynamics at scale: Lessons from the study of actin-based motility - Julie Theriot

From Mechanisms to Therapeutic Insight in Neurodegeneration
Presentations:

• Designed Ankyrin Repeat Proteins as tools to investigate the role of Leucine Rich Repeat Kinase 2 autoinhibition in Parkinson’s Disease linked mutants - Kathryn Hatch
  
• LASER senses lysosomal damage and initiates ESCRT assembly for membrane repair - Aakriti Jain
  
• Neuronal Aβ generation is elevated by Swedish APP bypassing a lysosomal trafficking pathway that degrades wild-type APP - Cameron Plowinske
  
• Lysosomal PI(4)P Signaling Links PIKfyve Dysfunction to Organelle Repair and Mitochondrial Homeostasis - Candice Kutchukian
  
• Novel crosstalk between TDP-43 oxidation and the GADD34-PP1 complex at RNA granule-mitochondria contact sites in ALS - Hannah Ball
  
• Harnessing PINK1 Kinase Molecular Glues to Trigger Mitophagy in Parkinson’s Therapy - Kumar Suresh

Bridging Structural and Cell Biology with Cryo-EM and Cryo-ET
Presentations:

• Structural Insights into Lysosomal Supercomplexes and Niemann-Pick Type C Pathology - Daniel Serwas
  
• Cryogenic electron tomography uncovers the native filamentous architecture of inactive lipoprotein lipase - Kathryn Gunn
  
• Tubulin variant-mediated allosteric effects modulate paclitaxel efficacy - Shih-Chieh Ti
  
• Architecture of HIV-1 capsid bound to the dynein transport machinery - Michael Cianfrocco
  
• The Eg5 motor, not spindle bipolarity, is responsible for assembling and maintaining interdigitated, anti-parallel microtubule bundles in metaphase spindles - William Conway
  
• Nanoscale Biopsy of Biomolecular Condensates: SOLIST Unlocks Phase Separation in Cancer and Beyond - Philipp Erdmann
• Coordination between mitochondrial fission and mitochondrial DNA replication - Nitish Dua
• Genetically encoded V-tag for molecular-resolution protein localization in 3D cellular imaging - Qiangjun Zhou

11:00 AM - 11:45 AM

Professional Development

LGBTQ+ Ally Session
Speakers:
Imge Ozugergin, Institut Pasteur - Paris, France
Claire Thomas, Pennsylvania State University

12:00 PM - 12:45 PM

Roundtable Discussions

Bridging Academia and Industry: Collaborative AI Approaches in Biomedical Research
Organizer: Sriparna Ghosh

Navigating Challenging Science Communication
Organizers: Quyen Aoh, Gannon University; Kaitlyn Casimo, Allen Institute; Sarah Vandal, Dartmouth College. This session is organized by members of ASCB's Science Communication, Outreach, and Public Engagement (SCOPE) Committee.

Mechanobiology for Nonexperts & Experts
Organizers: Dennis Discher, Guilherme Nader

Transferable Skills and Biotech
Organizer: David Elzi

Navigating Grant Funding Opportunities with NIGMS Program Directors
Organizer: Kalynda Gonzales Stokes

Alternative Career Paths in Microscopy: Core Facilities and Beyond
Organizer: Constadina Arvanitis

Meet with NSF BIO Program Officers
Organizer: Matthew Buechner

12:45 PM - 1:45 PM

Professional Development

Bridging the Gap: Advocating for Cell Biological Research to Policymakers and the Public
Speakers: TBD

12:45 PM - 2:15 PM

Professional Development

EMBO Training: Giving a Flash Talk or Poster Presentation
Speaker: Poonam Bheda, EMBO

1:00 PM - 4:00 PM

Professional Development

Career Coaching Sessions

2:15 PM - 3:45 PM

Professional Development

Raising mental health in the CellBio research community: sidestep stigma and learn peer and trainee support
Speakers: TBD

4:00 PM - 5:00 PM

Professional Development

Thriving in Uncertain Times: Navigating Career and Funding Challenges
Speakers:
Needhi Bhalla, University of California, Santa Cruz
Kandice Tanner, NCI/NIH
Jaye Gardiner, Tufts University
Iain Cheeseman, MIT

4:00 PM - 6:00 PM

Minisymposia

Cell Biology of the Nucleus - Form and Function
Presentations:

• Measuring Force Propagation and Mechanical Properties of the Chromatin in Live Cells - Ivan Surovtsev
  
• The material properties and organization of the synaptonemal complex regulate protein diffusion along meiotic chromosomes - Lexy von Diezmann
  
• Liver regeneration CRISPR screen identifies E3 ligase NEURL1B regulates hepatocyte mitosis by destabilizing microtubule organizing centers - Yuan Yao
  
• Decoding Enhancer-Mediated Control of Transcription Dynamics through Live-Cell Super-Resolution Imaging - Aniket Jana
  
• Quantitative analysis of the impact of local chromatin organization on transcriptional dynamics - Noel Buitrago
  
• Transcriptional activity generates chromatin motion that drives nuclear blebbing - Andrew Stephens
• Understanding the role of CENP-A in modulating responses to DNA damage and R-loops formation in human cancers - Elena Di Tommaso
• Topbp1 mediates the response to DNA damage and acentric chromosomes in inviable Xenopus hybrids - Cordell Clark

Epithelial cell polarity and polarized trafficking in organ health and disease
Presentations:

• The role of polarized vesicular trafficking in intestinal tissue homeostasis and ageing - Sandra Scharaw
  
• ESCRT-0 Condensation and Smoothened Clustering drive Extracellular Vesicle Budding from Cilia - Mingli Zhu
  
• Actomyosin cortex integration with plasma membrane topography over the one-cell Drosophila embryo - Rowan Naidoo
• Adapter sequestration and EGFR suppression are widespread features among oncogenic RTK fusions - Carol Gao 
• Occludin Links Endosomal Trafficking to Mitotic Spindle Assembly and Epithelial Morphogenesis - Pengfei Lu
• Matrix stiffness induces heritable changes in chromosome numbers, aligning with solid tumor heterogeneity - Markus Spranger
• EGFR S442 Mutation Drives Cetuximab Resistance via Impaired Antibody Binding and Sustained Signaling, Reversed by ERBB2 Co-Targeting - Bhuminder Singh

Metabolism and cell size in tissue regeneration
Presentations:

• The fate of pyruvate: metabolic regulation of cellular homeostasis - Ashish Toshniwal
• Endothelial Plasticity and Metabolic Stress: Mechanisms Driving Fibrotic Remodeling - Nazish Sayed
• Cell size homeostasis as basis for mTORC1 homeostasis, disease resilience and longevity - Ran Kafri
• A Novel Doxorubicin-Adaptive hiPSC Model Links Early Stem Cell Stress to Impaired Cardiomyocyte Maturation - Rosy Joshi-Mukherjee
• Cytoskeletal Control of Rosette Remodeling and Lumen Formation in the Zebrafish Left-Right Organizer - Yan Wu
• Gene Expression Changes Induced by MAHS Expression in Human Cells Include Stress-Associated Genes - Sara Nafar

Quantitative Modeling Insights for Cytoskeleton Dynamics and Cell Polarity
Presentations:

• STAGED: A Multi-Agent Neural Network for Learning Cellular Interaction Dynamics - Dhananjay Bhaskar
  
• Space Negotiation Strategies of Cells Invading Extracellular Matrix: Lessons from a Physics-Based Model - Andreas Buttenschoen
  
• Context-dependent spatial multicellular network motifs for single-cell spatial biology - Assaf Zaritsky
• Using mathematical modeling to understand mechanisms of microtubule dynamics and polarity in neurons - Anna Nelson
• Organelle packing interactions and cell anatomy patterns revealed by whole-cell imaging: a two-pronged approach - Mary Mirvis

The Centrosome in Cell Division, Development, and Disease
Presentations:

• Orb2 is required for neural stem cell centrosome and cell size asymmetries - Joey Buehler
  
• The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication - Abraham Martinez
  
•  Liver regeneration CRISPR screen identifies E3 ligase NEURL1B regulates hepatocyte mitosis by destabilizing microtubule organizing centers - Dingzi Yin
  
• Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of fungi with motile cilia - Alexandra Long
  
• Isotropic ultrastructural imaging reveals novel membrane organization in ciliogenesis initiation - Quanlong Lu
  
• A novel mechanism for centrosome expulsion ensures metabolic activity in polyploid cells - Renata Basto
• A KASH-less Msp300 isoform has a novel outer nuclear membrane targeting domain and scaffolds the non-centrosomal microtubule organizing center in fat body cells - Tania Sultana
• A mechano-chemical model for γTuRC-mediated microtubule nucleation - Kenneth Tsui

5:30 PM - 6:30 PM

Professional Development

Teaching with authentic data and open science: opportunities, best practices, and outcomes
Speakers: TBD

9:00 AM - 11:00 AM

Minisymposia

Cell Adhesion, Migration and the Extracellular Environment
Presentations:

• Nematic fluctuation of FA elements, energized by active forces, mediates “patrolling” mechanosensing - Congying Wu
  
• Long range mutual activation establishes Rho and Rac polarity during cell migration - Henry De Belly
  
• Neutrophil migration patterns change in response to elevated extracellular viscosity - Daniel Yan
  
• Dynamics and underlying mechanism of chemotaxis in the green algae model system Chlamydomonas reinhardtii - Alexis Strain
  
• DAAM1 formin and VASP polymerize functionally distinct actin filament populations at focal adhesions - Xiang Le Chua
• Intracellular pH modulates cancer migration phenotypes under compressive environments - Carlos Arias-Matus
• Protein Glycosylation Pathway Mutants of Pseudomonas aeruginosa Show Distinct Phenotypes in Biofilm Formation - George Trekell
• Novel spatial arrangement of signaling modules driving mechanics of bleb-based migration - Ankita Jha

Mechanisms of Protein Turnover and Roles in Terminally Differentiated Cells
Presentations:

• A novel ribosome assembly surveillance pathway (RASP) ensures continuous ribosome production and maintains cellular proteostasis - Kamena Kostova
  
• PP2A and CDK16 regulate WIPI2B phosphorylation and neuronal autophagy - Heather Tsong
  
• SNX-RGS proteins are conserved phospholipid transporters which loss causes lysosome membrane lipid disruption and neurodegeneration - Vanessa Sanchez
  
• Enhanced recruitment of lysosomal repair pathways in response to lysosomal damage in astrocytes versus neurons - Erin Smith
  
• Analysis in vivo using a new method, ARGO (Analysis of Red-Green-Offset), reveals complexity, cell-type specificity, and requirement for TFEB/HLH-30 in presynaptic turnover of synaptic vesicle protein Synaptogyrin/SNG-1 - Claire Richardson
• The Autophagy Protein BECN1 Regulates AMPA Receptor Stability To Promote Social Behavior - Congcong He
• Uncovering mechanisms underlying the trans-cellular spreading of tau and a-synuclein in neurodegenerative diseases - Eloïse Néel

Spatiotemporal Control of Cell Signaling Across Scales
Presentations:

• Temporal-spatial regulation of protein synthesis and degradation serves as a key checkpoint of G0 transition and fate change - Rachel Turn
  
• A Dynamical Systems Framework Applied to Live Cell Imaging of hiPSC-Derived Endothelial-Like Cells Under Flow Uncovers a First-Order Phase Transition Between Morphology-Based Cell States - Serge Parent
  
• ERK signaling dynamics and alveolar epithelial cell fate - Evelyn Navarro Salazar
• Integrating molecular dynamics and high-speed single-molecule tracking to link protein structure and function - Safal Shrestha
• PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration - Yu Deng
• Synchronous Erk Oscillations Control the Pace of Zebrafish Notochord Segmentation - Priyom Adhyapok
• Single-Molecule Tracking Reveals Amphiregulin Mediated Modulation of HER2 - Eric Burns
• Metabolic-STAMP reveals spatiotemporal kinase signaling and phosphorylation node logic during GPCR-regulated insulin secretion in pancreatic β-cells - Mohammad Ovais Azizzanjani

The Endoplasmic Reticulum: Master Regulator of Cellular Homeostasis
Presentations:

• SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis - Shanshan Liu
  
• The Role of the GRP170 Molecular Chaperone in Endoplasmic Reticulum, Cellular, and Organismal Proteostasis - Jeffrey Brodsky
• Roles of ubiquitin-fold modifier 1 (UFM1) in protein quality control at the endoplasmic reticulum - Yihong Ye
• Direct visualization of ER-associated degradation by correlative, real-time single protein tracking - Christopher Obara
• Organization of specialized ER subdomains for lipid droplet biogenesis - Amit Joshi
• Derlins in control: shaping sphingolipid metabolism and mitochondrial dynamics - Nicola Scott
• ER-Shaping Proteins and Contact Site Organization in the Differentiated Sarcoplasmic Reticulum - Ana Pereira
• Unraveling the architecture of an ER stress sensing complex - Malaiyalam Mariappan
• The kinesin-14 Kar3-Vik1 is required for Endoplasmic Reticulum-Associated Degradation - Eric Rubenstein
• The Small Molecule, BRD4780, Prevents ER-export to the Cell Surface and Promotes ER-degradation of Misfolded GPI-anchored Proteins - Prasanna Satpute-Krishnan

Interplay Between Nuclear Pore Complex and Cell Physiology
Presentations:

• A conserved mechanism of membrane fusion in nuclear pore complex assembly - Jonas Fischer
  
• GlcNAcylation of NPCs modulates the diffusion barrier in response to cell type and mechanical state - Sunandini Chandra
• The role of Spindle Assembly Checkpoint proteins at Nuclear Pore Complexes: Implications beyond Chromosome Segregation - Sanjana Sundararajan
• Reconstitution of lamin assembly on nuclear pore complex-containing membranes - Ross Pedersen
• Early Inner Nuclear Membrane Deformations Induced by Progerin Are Modulated by Cell Division - Ayse Turkmen
• ESCRT III-Driven Repair of Nuclear Rupture Reverses Transcriptional Arrest in Lamin-Related Cardiomyopathy - Kohta Ikegami
• Fission yeast SPB proteins establish an alternative proteinaceous diffusion barrier at the nuclear envelope during mitosis - William Chadwick
• Determining the order of import of nuclear proteins post-mitosis required for the gradual activation of mRNA transcription, processing and export - Yaron Shav-Tal

11:15 AM - 12:30 PM

Closing Keynote

Visualizing Form and Function in the Cell
Speakers:
Eva Nogales, University of California, Berkeley
Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute/Janelia Research Campus