Illuminating cell organization with CRISPR-based gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease. Scientists deploy glowing fluorescent tags to help them visualize  … Read more

MBoC plans special issue on Forces On and Within Cells
October 2017 Newslettermboc

David Drubin, Editor-in-Chief of Molecular Biology of the Cell (MBoC), and Valerie Weaver, an Associate Editor of MBoC, have announced plans to publish a second special issue on “Forces On and Within Cells.” The first such special issue was published in July 2017 ( Weaver,  … Read more

What’s it all about? Organoids

The second installment of the “What’s it all about series?” aims to tackle the broad utilization of in vitro three-dimensional (3D) culture models, termed organoids. There are numerous definitions for what constitutes an organoid, and just as many applications for their use. Though sometimes hard  … Read more

Cryo-EM: Nobel Prize-winning technique that’s sharpening view into cells

The 2017 Nobel Prize in Chemistry has been awarded to the team of scientists responsible for developing cryo-electron microscopy (cryo-EM), which allows researchers to view biomolecules with high resolution. The Nobel laureates include Jacques Dubochet of the University of Lausanne, Switzerland; Joachim Frank of Columbia  … Read more

Understanding nature through description
September 2017 NewsletterPresident's Columns

I had the good fortune to have an exceptionally good anatomy teacher during my first year of medical school. One of the exercises during labs was to identify structures. I recall how adamant he was in expecting us not to rush to a “guess,” even  … Read more

What’s it all about? CRISPR/Cas

Science changes over time. The collective knowledge of a field builds upon itself as new techniques allow us to ask new questions and find new answers. Sometimes as trainees we become ultra-focused on our current experiments and projects, missing these shifts in standards. Have you noticed  … Read more

Nanoscale forces measured in aortic smooth muscle cells tell story of disease

Researchers from Virginia Tech and the University of Pittsburgh have collaborated to employ a novel nanoscale fibrous system that can measure the tiny forces exerted by and upon individual cells with extreme precision. The team hopes that this platform, which investigators call nanonet force microscopy  … Read more

Data deleted, truth denied

Making data disappear does not change the truth. We find ourselves in a dangerous moment where data and science— availability and process—are concerned. Anyone working in science has seen the consequences of data manipulation by scientists themselves: shame, censure, and the spite of your colleagues  … Read more

Harris’s book explores critical topic of scientific rigor

The American Society for Cell Biology (ASCB) was one of the first to highlight issues of reproducibility with science, so it was with great anticipation that I picked up Richard Harris’s book, Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope and Wastes Billions.  … Read more

Green Is Not the New Gold: Beware of False Models for Open Access
March/April 2017 NewsletterPresident's Columns

This President’s Column is by guest columnist Maria Leptin, Director of the European Molecular Biology Organization (EMBO). EMBO and ASCB are holding joint meetings in 2017 and 2018. Publishing scientific results involves a large and complex network of participants and interested parties, each with its  … Read more