Subgroup P: The Cellular and Molecular Basis of Invasive Metastatic Cancer (Room 32B)

Tuesday, December 15, 3:00 pm–6:30 pm

ORGANIZERS: Mark A. McNiven, Mayo Clinic; Laura M. Machesky, Beatson Institute, Cancer Research UK; and Alissa M. Weaver, Vanderbilt University

This subgroup will focus on understanding the important and widespread process of how tumor cells actively interact with and remodel the surrounding microenvironment through a combination of migration, matrix degradation, physical forces, and signal transduction during the metastatic process. The program will feature experts in matrix biology, tumor microenvironment, cytoskeletal and organelle dynamics, in situ live cell imaging, mouse and other genetic model systems, and human pathology to provide a state-of-the-art update on new findings and technologies to both understand and curtail metastatic disease.


3:00–3:10 pm Introduction. Alissa M. Weaver, Vanderbilt University; Mark A. McNiven, Mayo Clinic; Laura Machesky, Beatson Institute, Glasgow, UK
3:10–3:35 pm Actin cytoskeletal control of migration and metastasis of pancreatic cancer. Laura Machesky and Amelie Juin, Beatson Institute, Glasgow, UK
3:35–4:00 pm Mechanical and structural cues within the 3D microenvironment in metastatic cell migration. Cynthia Reinhart-King, Cornell University
4:00–4:25 pm The role of the physical microenvironment in cancer cell invasion.  Denis Wirtz, Johns Hopkins University
4:25–4:50 pm When cells collide: contact inhibition as a migratory cue. Brian Stramer, King’s College London, UK
4:50–5:15 pm Stromal-tumor cell interactions in matrix remodeling. Gina L. Razidlo and Mark A. McNiven, Mayo Clinic
5:15–5:40 pm Localized energy sensing through LKB1 and AMPK recruits mitochondria to the leading edge. Alan Howe, University of Vermont
5:40–6:05 pm Wnt5a regulates protein depalmitoylation to promote polarized cell movement. Eric Witze, University of Pennsylvania
6:05–6:30 pm Stromal regulation of tumor aggressiveness. Erik Sahai, Francis Crick Institute, London, UK


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