Catching Single Molecules in the Act

The ongoing quest to delve ever deeper into a living cell has brought new insight into dynamic biological processes. But conditions inside a cell, including crowds of individual molecules, often flout the best efforts of modern imaging technology to observe activity. And that’s not to  … Read more

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Zooming in on Imaging with New Technologies

Biologists now can see more clearly inside cells than ever have been able to before. But there are advantages and challenges to each of the new imaging technologies becoming available. So some of the brightest minds in cell imaging spoke Sunday at an afternoon workshop  … Read more

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Nanoparticles Probe Cell Signals Precisely

We may know a great deal about how cells interact with their environment and each other, but we haven’t been able to get down to the nitty-gritty of how those signal pathways work at a molecular, or even cell-wide, level. Traditional tools like atomic force  … Read more

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Glowing Stem Cell Structures Light a Path Toward Understanding

Getting a clearer view inside a normal cell is a critical part of understanding what goes wrong when disease sets things awry. At Saturday’s sub-group meeting on the biology of stem cells, the Allen Institute for Cell Science debuted the first group of human induced  … Read more

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Hitting the Drug Target—Can a 3D Cell Cycle Scoring System Help Understand What’s Really Going on in Tumors?

The promise of targeted cancer therapies depends on knowing which target is truly being hit. Say you have an effective drug that you believe is inhibiting mitosis in tumors. Confirming the exact mechanism of action on the single cell level might allow finer tuning or  … Read more

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