Cell Organization & Cell Motility - Part 1, Julie Theriot

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Cell Organization & Cell Motility
Julie Theriot, May 2006
Stanford University, Dept of Biochemistry, Dept of Microbiology & Immunology, Program in Biophysics

Lecture Overview
This lecture covers the biochemical basis of actin-based motility (focusing on the pathogen Listeria as a model system for this process), the biophysical mechanism of polymerization-based force generation, and an evolutionary perspective of cell shape in prokaryotes and eukaryotes. The first part covers our understanding of how cells use the actin cytoskeleton to crawl. The pathogenic bacteria Listeria (which causes food poisoning) uses the actin cytoskeleton to propel itself in the cytoplasm and also invade other cells. This system has been an important model for understanding the actin cytoskeleton at the leading edge of a motile cell and for understanding host-pathogen interactions.
Part 1: Cell Motility and the Cytoskeleton:
Protein Polymers Crawling Cells and Comet Tails (43:53)

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Downloads in alternative formats:
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QuickTime (88mb)      MP4 (358mb)      iPod Video (262mb)
PowerPoint Slides 1/page (1.2mb)     PowerPoint Slides 6/page (914kb)

Format Descriptions
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Part 2: Force Generation by Actin Assembly: Theories and Experiments (46:16)

Part 3: Principles of Cellular Organization: The Universal Cytoskeleton (29:17)

Speaker Bio   Related Articles

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Lecture Overview This lecture covers the biochemical basis of actin-based motility (focusing on the pathogen Listeria as a model system for this process), the biophysical mechanism of polymerization-based force generation, and an evolutionary perspective of cell shape in prokaryotes and eukaryotes. The first part covers our understanding of how cells use the actin cytoskeleton to crawl. The pathogenic bacteria Listeria (which causes food poisoning) uses the actin cytoskeleton to propel itself in the cytoplasm and also invade other cells. This system has been an important model for understanding the actin cytoskeleton at the leading edge of a motile cell and for understanding host-pathogen interactions.	Part 1: Cell Motility and the Cytoskeleton: Protein Polymers Crawling Cells and Comet Tails (43:53) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (88mb) MP4 (358mb) iPod Video (262mb) PowerPoint Slides 1/page (1.2mb) PowerPoint Slides 6/page (914kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Force Generation by Actin Assembly: Theories and Experiments (46:16) Part 3: Principles of Cellular Organization: The Universal Cytoskeleton (29:17) Speaker Bio Related Articles