Protein Secretion and Vesicle Traffic - Part 3, Randy Schekman

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Protein Secretion and Vesicle Traffic
Randy Schekman, March 2007
Department of Molecular and Cell Biology, HHMI, University of California, Berkeley

Lecture Overview
Human COPII genes are duplicated and some may have evolved specialized functions. Two rare human diseases affect the activity of one of two copies of Sar1 and the Sec23A subunit of the COPII coat. Anderson's disease results in the failure of enterocytes of the absorptive epithelium to secrete large lipoprotein particles called chylomicrons. Point mutations in one of two copies of Sar1 results in the accumulation of chylomicrons in the ER. CLSD, a rare craniofacial disorder likely due to the selective failure of secretion of certain connective tissue proteins such as collagen, is caused by a conservative amino acid substitution in Sec23A that blocks completion of COPII coat assembly.
Part 3: Human Diseases of Vesicle Budding (32:28)

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Format Descriptions
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Part 1: Genetic Dissection of the Secretory Pathway (36:35)

Part 2: Biochemical Reconstitution of Transport Vesicle Budding (25:14)

Speaker Bio    Related Articles

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Lecture Overview Human COPII genes are duplicated and some may have evolved specialized functions. Two rare human diseases affect the activity of one of two copies of Sar1 and the Sec23A subunit of the COPII coat. Anderson's disease results in the failure of enterocytes of the absorptive epithelium to secrete large lipoprotein particles called chylomicrons. Point mutations in one of two copies of Sar1 results in the accumulation of chylomicrons in the ER. CLSD, a rare craniofacial disorder likely due to the selective failure of secretion of certain connective tissue proteins such as collagen, is caused by a conservative amino acid substitution in Sec23A that blocks completion of COPII coat assembly.	Part 3: Human Diseases of Vesicle Budding (32:28) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (61mb) MP4 (376mb) iPod/iPhone Video (376mb) PowerPoint Slides 1/page (1.1mb) PowerPoint Slides 6/page (444kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Genetic Dissection of the Secretory Pathway (36:35) Part 2: Biochemical Reconstitution of Transport Vesicle Budding (25:14) Speaker Bio Related Articles