Growth Control in Animal Development

Home | About | Credits | Seminar List | Poster | Feedback

Growth Control in Animal Development
Martin Raff, Nov. 2006
MRC Laboratory for Molecular Cell Biology

Lecture Overview
In the second segment of my talk, I describe our work on cell number control in the rat oligodendrocyte cell lineage. Cell numbers depend on controls on both cell death and cell proliferation. We have found that oligodendrocytes are normally overproduced and kill themselves in large numbers in a competition for survival signals on the surface of the axons that the oligodendrocytes myelinate. Most differentiated cells, including oligodendrocytes, develop from dividing precursor cells that divide a limited number of times before they terminally differentiate, but it is not known what stops cell division and initiates differentiation. We have found that oligodendrocyte precursor cells have an intrinsic timing mechanism that helps determine when they stop dividing and differentiate.

Part 2: Cell Number Control (37.13)

Click image above to start seminar in 320x240 format
Click here to view in larger 640x480 format*
QuickTime 7 Required    *640x480 System Requirements
(there may be a few seconds delay before seminars start)

Downloads in alternative formats:
(To Save, Right Click a link below and select "Save Target/Link As")
QuickTime (60mb)     MP4 (104mb)     iPod/iPhone Video (446mb)
PowerPoint Slides 1/page (921kb)     PowerPoint Slides 6/page (418kb)

Format Descriptions
Download Accelerator/Resume Broken Downloads Software

Part 1: Cell Size Control (40:56)

Speaker Bio    Related Articles

Disclaimers, Trademarks, & Terms of Use
© 2008 The American Society for Cell Biology
8120 Woodmont Avenue Suite 750, Bethesda, MD 20814-2762
Phone: (301) 347-9300 Fax: (301) 347-9310

Lecture Overview In the second segment of my talk, I describe our work on cell number control in the rat oligodendrocyte cell lineage. Cell numbers depend on controls on both cell death and cell proliferation. We have found that oligodendrocytes are normally overproduced and kill themselves in large numbers in a competition for survival signals on the surface of the axons that the oligodendrocytes myelinate. Most differentiated cells, including oligodendrocytes, develop from dividing precursor cells that divide a limited number of times before they terminally differentiate, but it is not known what stops cell division and initiates differentiation. We have found that oligodendrocyte precursor cells have an intrinsic timing mechanism that helps determine when they stop dividing and differentiate.	Part 2: Cell Number Control (37.13) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (60mb) MP4 (104mb) iPod/iPhone Video (446mb) PowerPoint Slides 1/page (921kb) PowerPoint Slides 6/page (418kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Cell Size Control (40:56) Speaker Bio Related Articles