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Tuberculosis: A Persistent Threat to Global Health John D. McKinney, June 2007 Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL) |
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| Lecture Overview
The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary "persisters" that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of this lecture describes recent work in our laboratory using microfluidics and time-lapse microscopy to analyze the behavior of drug-stressed bacteria at single-cell resolution. These studies challenge conventional views of how antimicrobials kill (or fail to kill) bacteria. |
Part 3: Phenotypic Heterogeneity and Antibiotic Tolerance (27:15)
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QuickTime (51mb)
MP4 (319mb)
iPod/iPhone Video (319mb) |
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 Part
1: Tuberculosis: The Once and Future Plague (27:33)
 Part
2: Tools for Tuberculosis Control: Not Just a Problem of Implementation (28:18)
 Part
4: Targeting M. tuberculosis Carbon Metabolism
In Vivo (26:12) |
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