Membrane Rafts - Part 2, Satyajit 'Jitu' Mayor

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Membrane Rafts
Satyajit 'Jitu' Mayor, May 2007
Cellular Organisation and Signalling, National Centre for Biological Sciences, Bangalore, India

Lecture Overview
In this part, I focus on our laboratory's ongoing preoccupation with rafts where we study the characteristics a popular "raft-marker", a class of cell surface lipid-tethered proteins, the GPI-anchored proteins. These lipid-tethered molecules are sorted at the cell surface into a specialized endocytic pathway, suggesting their segregation at the cell surface. Here I describe collaborative interdisciplinary work from my laboratory and that of my physicist colleague, Prof. Madan Rao, where we explore the organization of lipid-tethered proteins in living cells using new biophysical tools developed for this purpose. These studies have compelled us to refine the notion of membrane rafts as functional lipid-assemblies consisting of nanoscale clusters and monomers. This organization appears to be characteristic of many other putative "raft" lipids and lipid-anchored proteins at the inner and outer leaflet of cell membranes.
Part 2: Looking for Functional Rafts in Cell Membranes (41:55)

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Format Descriptions
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Part 1: Historical Perspective: What are Membrane Rafts? (38:19)

Part 3: Making Rafts in Living Cell Membranes (20:39)
not yet available

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Lecture Overview In this part, I focus on our laboratory's ongoing preoccupation with rafts where we study the characteristics a popular "raft-marker", a class of cell surface lipid-tethered proteins, the GPI-anchored proteins. These lipid-tethered molecules are sorted at the cell surface into a specialized endocytic pathway, suggesting their segregation at the cell surface. Here I describe collaborative interdisciplinary work from my laboratory and that of my physicist colleague, Prof. Madan Rao, where we explore the organization of lipid-tethered proteins in living cells using new biophysical tools developed for this purpose. These studies have compelled us to refine the notion of membrane rafts as functional lipid-assemblies consisting of nanoscale clusters and monomers. This organization appears to be characteristic of many other putative "raft" lipids and lipid-anchored proteins at the inner and outer leaflet of cell membranes.	Part 2: Looking for Functional Rafts in Cell Membranes (41:55) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (77mb) MP4 (490mb) iPod/iPhone Video (490mb) PowerPoint Slides 1/page (1.6mb) PowerPoint Slides 6/page (1mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Historical Perspective: What are Membrane Rafts? (38:19) Part 3: Making Rafts in Living Cell Membranes (20:39) not yet available Speaker Bio Related Articles