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Host-Pathogen Interaction and Human Disease Stanley Falkow, May 2007 Stanford University School of Medicine /Department of Microbiology and Immunology

Lecture Overview Helicobacter pylori lives in the human stomach. It causes gastritis, ulcer disease and even gastric cancer. Some H. pylori can inject a protein, CagA, into gastric epithelial cells. CagA interacts with the tight junctions that bind cells together and with signaling molecules affecting motility and proliferation. CagA is associated with ulcer disease and cancer but we don't understand how it works to favor malignancy. Not long ago in history most humans carried H. pylori ; the incidence of carriage and gastric cancer is dropping but there is evidence that this microbe also had a protective effect on human health.

Part 2: Helicobacter pylori and Gastric Cancer (48:57) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format*   QuickTime 7 Required    *640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats: (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (92mb)     MP4 (572mb)     iPod/iPhone Video (572mb) PowerPoint Slides 1/page (4.7mb)     PowerPoint Slides 6/page (2.2mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software

Part 1: What is a Pathogen? Trying to Understand Human Biology by the Study of Pathogenic Bacteria (37:48)   Speaker Bio    Related Articles

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