Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies
Brian Druker, March 2007
HHMI / Oregon Health & Science University Cancer Institute

Lecture Overview
The lessons learned from the clinical trials of imatinib will be reviewed in this section. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to other malignancies. The section concludes with what this means for research to control or cure cancer in the coming decades.
Part 3: Extending the Imatinib Paradigm (22:09)

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PowerPoint Slides 1/page (144kb)     PowerPoint Slides 6/page (59kb)

Format Descriptions
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Part 1: Chronic Myeloid Leukemia (CML) and Imatinib (33:54)

Part 2: Imatinib Resistance and Other Diseases Targeted by Imatinib (25:12)

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Lecture Overview The lessons learned from the clinical trials of imatinib will be reviewed in this section. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to other malignancies. The section concludes with what this means for research to control or cure cancer in the coming decades.	Part 3: Extending the Imatinib Paradigm (22:09) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (41mb) MP4 (259mb) iPod/iPhone Video (259mb) PowerPoint Slides 1/page (144kb) PowerPoint Slides 6/page (59kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Chronic Myeloid Leukemia (CML) and Imatinib (33:54) Part 2: Imatinib Resistance and Other Diseases Targeted by Imatinib (25:12) Speaker Bio Related Articles