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Adhesion, Signaling and Cancer Mary C. Beckerle, July 2007 Huntsman Cancer Institute, University of Utah

Lecture Overview In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed.

Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format*   QuickTime 7 Required    *640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats: (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (94mb)     MP4 (595mb)     iPod/iPhone Video (595mb) PowerPoint Slides 1/page (1.3mb)     PowerPoint Slides 6/page (618kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software

Part 1: Understanding Cancer From Its Beginnings (36:04)   Part 3: Focal Adhesions as Stress Sensors (30:57) Speaker Bio    Related Articles

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