The UPR has unfolded into the 2014 Albert Lasker Basic Medical Research Award for ASCB President-Elect for 2016 Peter Walter. A Howard Hughes Medical Institute investigator and Professor of Biochemistry and Biophysics at the University of California, San Francisco (UCSF), Walter was named co-winner winner today along with Kazutoshi Mori of Kyoto University for their independent but closely related work on untangling the unfolded protein response or UPR, a signaling pathway that protects cells by flagging misfolded proteins in the cytoplasm and switching on a protective response.
In Hollywood and in 3D molecular printing, you start with a script. But the scripts that Darrell Hurt offers bioscience researchers help them to make molecular discoveries more easily. Hurt is the section head at the Computational Biology Bioinformatics and Computational Biosciences Branch at the NIH, where he recently launched the NIH 3D Print Exchange. http://3dprint.nih.gov/ The Exchange offers open-access to ready-to-use scripts, the instructions that drive 3D printers, so scientists can turn their .pdb and other data files into print-it-yourself plastic models.
It's rare to find a young scientist in a big office, yet Gregory Alushin, age 29, has generous space, a U-shaped desk, and a floor-to-ceiling window with a view of the NIH campus. He is semi-apologetic about the arrangement, insisting that it's only temporary. "We're going to have to leave this place in a few months," Alushin hastily explains. "Another institute had just moved out of this space so we got to be the temporary sole occupants." His lab was founded only seven months ago, says Alushin, and he doesn't want to get too comfortable.
"I grew up in a very big family in a very small house," says Lydia Villa-Komaroff. That house was in Santa Fe, New Mexico, where few Mexican-American kids like herself were lucky to even finish high school. But Villa-Komaroff knew from a young age that she wanted to become a scientist. She remembers when she was nine, hearing her uncle talking about his work as a chemist and deciding that this sounded like the career for her. "All children are scientists, but... I think it gets lost because people forget about the excitement and the joy of discovery," she says. "I wanted to continue to explore things, take them apart, put them back together."
Fishermen can tell you many tales of the teleosts but most cell biologists know but one—the zebrafish. That's a shame, says John Postlethwait, professor of biology at the University of Oregon, who made his scientific mark with the zebrafish but is a fan of a much wider circle of the teleosts, ray-finned fish whose ranks include nearly all of the important sport or commercial bony fish on Earth. Postlethwait thinks there are discoveries to be made amongst the lesser-known teleosts. Consider the blackfin icefish, a three-foot long, shovel-jawed fish that once almost set an Antarctic research station on fire. The blackfin icefish may hold clue to osteoporosis, he says.
The 40 came from all over North America, Europe, and Africa, 24 grad students and 16 postdocs, chosen from the 532 applications the ASCB received from members for a special 12-day "short" course on "Managing Science in the Biotech Industry" at the Keck Graduate Institute (KGI) with funding from EMD Millipore. Besides their ASCB connection, what the participants had in common were years of academic training and a curiosity about life in biotech.
Sometimes in science it pays to turn over a new leaf or an old laboratory animal. Stephen M. King at the University of Connecticut Health Center recently turned over planarian Schmidtea mediterranea, the nonparasitic flatworm justly renowned for its incredible regenerative powers, and saw on its underside a new way into a old problem. King, who is an ASCB member, believes that planaria could be an alternate model system for studying ciliary motility and its associated diseases now known as ciliopathies.
Sebastian Mana-Capelli of the University of Massachusetts Medical School was named by the Molecular Biology of the Cell (MBoC) Editorial Board as recipient of the 23nd annual MBoC Paper of the Year Award. As a postdoc in Dannel McCollum's lab, Mana-Capelli was first author of the article "Angiomotins link F-actin architecture to Hippo pathway signaling" (Mol. Biol. Cell 25, 1676–1685).
Yale professor, Howard Hughes Medical Institute investigator, and ASCB member, Joan Argetsinger Steitz has been elected a foreign member of the Royal Society in the UK. Steitz was an early pioneer in RNA biology, discovering much of the machinery and key players in RNA splicing. She went onto elucidate the role of small nucleic ribonucleoparticles (snRNPs or "snurps") in modifying non-coding introns and continues her work on microRNAs in gene regulation. The Royal Society membership joins a long list of Steitz's honors and awards including the Gairdner International Award in 2006 and the ASCB's highest scientific honor, the E.B. Wilson Medal, in 2005.
ASCB President-Elect Peter Walter, professor of biochemistry and biophysics at the University of California, San Francisco (UCSF), is the co-winner of the 2014 Shaw Prize in Life Sciences and Medicine. Walter, who is also a Howard Hughes Medical Institute investigator, will share the $1 million Shaw Prize with Kazutoshi Mori of Kyoto University for their work on the unfolded protein response (UPR), the cell's quality control response to an accumulation of defectively folded proteins.