It may begin as a "simple" foot blister, but for patients with type 2 diabetes there is nothing simple about wounds that won't heal. That blister can evolve into a seriously infected wound that refuses to heal and, if gangrene develops, the patient's foot may have to be amputated. Such "simple" foot blisters and other diabetic ulcers or sores account for the vast majority of foot and leg amputations in the U.S. today. Paraplegics, quadriplegics, and anyone with severely limited mobility are also highly vulnerable to these chronic skin wounds as well as pressure ulcers and bedsores. Together, chronic wounds affect an estimated 6.5 million Americans at an annual cost of about $25 billion.
It seems an unlikely connection, and yet there is a significant link between Gaucher disease (GD), a purely genetic disease affecting lipid storage, and Parkinson's disease, a largely untreatable progressive degenerative movement disorder of the central nervous system that is often without a clear genetic cause. Those born with two recessive GD mutations, which cause a dangerous build-up of lipids, have a higher risk of developing Parkinson's disease than those with normal GD genes. More surprising is the higher risk for Parkinson's disease among carriers of GD mutation who have no overt GD symptoms, but still produce some level of the defective enzyme called glucocerebrosidase.