Wednesday, 19 February 2014 10:32

Of Carp and Protein Translocation

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For those who think scientific discoveries pop up overnight, consider Tom Rapoport's tale of the holiday carp and how it led him to study the translocation channel through which proteins, such as insulin, are secreted. Rapoport's latest discovery starts with a fish 30 years ago and ends, or at least continues, this month with a publication in Nature of the first x-ray structure of an open protein translocation channel.

John Pringle has been going to different sorts of meetings this last decade. He is still a regular at the ASCB Annual Meeting and at smaller yeast biology gatherings. Indeed he was in New Orleans for the ASCB Annual Meeting in December to receive the E.B. Wilson Medal, the ASCB's highest scientific honor, for his pioneering work on cell polarization and cytokinesis. But Pringle also goes, when he can, to the International Coral Reef Symposium, the Society for Microbial Ecology, and the International Symbiosis Society. He still has a small yeast group in his lab although his other interests have represented the majority since 2007. He is becoming known at these marine biology and ecology meetings, but Pringle says that he wishes there were more cell biologists there. John Pringle aims to correct that.

Dear fellow bench scientist,
I cannot tell a lie. Dr. Washington is off today. But if you're working hard in the lab, either because your PI or your inner PI (you) requires it, Dr. Washington has a workaround. Sure, your Facebook friends are posting selfies with their President or El Presidente cocktails. But put down the beaker of despair (think of alcohol as just more glassware to wash) and take Dr. Washington's Instant Holiday.

Biologists are passionate about papers. Here we ask an ASCB member to pick two journal articles that were important, either personally or scientifically, and to answer—briefly and informally—three questions: Why did you pick this paper? What's it about? What does it mean to you?

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