Nearly every cell in your body is releasing microscopic bubbles that contain tiny messages to other cells in your body. The bubbles are so small that if a cell were the size of the Empire State Building, the vesicles would be the size of teenage couriers, running to deliver messages to neighboring buildings in the organism of Manhattan. But now there's evidence that at least in worms, these little bubbles, called extracellular vesicles (ECVs), can leave the cells of the Manhattan Island worm to deliver messages to cells in the Brooklyn worm. The first of these external messages to be discovered turns out to be a love note.
It's been nearly 14 years since the primary cilium pushed its way into cell biology's center ring with the discovery that this "irrelevant" vestigial organelle was connected to a common and fatal human disorder, polycystic kidney disease (PKD). In the years since, a long list of diseases and disorders have been classified as ciliopathies while the primary cilium currently has 2,347 citations on PubMed.
It was an all-or-nothing moment. Titia de Lange, a newly hired assistant professor at the Rockefeller University, had months of prep work and her entire grant's supply budget in hand as she waited to cross York Avenue, the busy north-south street on Manhattan's Upper East Side that separates Rockefeller from Memorial Sloan-Kettering Cancer Center, where a collaborator was waiting to sequence de Lange's protein distillate. "We walked with all the protein we had from 1,500 liters of HeLa cells," de Lange recalled. "If we had tripped it would have been a problem. "It was a potentially self-destructive experiment, but it worked."
Consider it progress but many in Congress are coming around to the idea that the current system for funding the U.S. National Institutes of Health (NIH) and other federal science programs isn't working. Getting everyone on the Hill to agree what should be done to protect research funding is another matter. Now, one senator has come up with a daring new idea on how to shelter biomedical research funding from the budgetary hurricanes blowing through both chambers.