ASCB President-Elect Peter Walter, professor of biochemistry and biophysics at the University of California, San Francisco (UCSF), is the co-winner of the 2014 Shaw Prize in Life Sciences and Medicine. Walter, who is also a Howard Hughes Medical Institute investigator, will share the $1 million Shaw Prize with Kazutoshi Mori of Kyoto University for their work on the unfolded protein response (UPR), the cell's quality control response to an accumulation of defectively folded proteins.
David L. Spector of the Cold Springs Harbor Lab (CSHL), a scientist long known for his pioneering work in live cell imaging of the nucleus and its surprisingly fluid geography and population, has been named to a pair of prestigious memberships, one in the American Academy of Arts & Sciences and the other in EMBO, the European Molecular Biology Organization. Spector, who is both a professor and Director of Research at CSHL, has been an ASCB member since 1980. He chaired the ASCB Annual Meeting program committee in 2008 and served on ASCB's governing Council from 2010 to 2012.
Once you could pity the lamins. As intermediate filaments, the lamins were often slighted as awkward siblings in between actin and microtubules. Found right under the inner nuclear membrane, lamins were regarded as little more than building materials for the nuclear lamina consisting of additional nuclear proteins. No more. Lamins have come up in the cell world, tied in recent years to transcriptional regulation and linked directly to a rare human developmental disorder of rapid aging called Hutchinson-Gilford progeria syndrome. But their fundamental place in eukaryotic cell biology remained unclear. Lamins are ubiquitously conserved across metazoans but are they essential to cell life?
The Big Day dawns at last. As the sun heaves itself out of the Atlantic Ocean this morning and Boston stirs to life, the Dicty World Race will roar into action in the Massachusetts General Hospital lab of Dan Irimia. Twenty teams have sent in their finely tuned racing organisms to settle the question of which will be faster in a race against the clock through a microfluidic maze, the Dictyostelium discoideum a.k.a. Dicty, the slime mold with a vast reputation (and literature), or a human neutrophil-like cell line called HL-60. You can follow the action live here.