A Sound-Based Probe for Cellular Mechanics
December 2018 Newsletter

Researchers from the laboratory of Gijs Wuite at Vrije Universiteit in Amsterdam, The Netherlands, collaborating with scientists from Weizmann Institute of Science in Israel, University of Groningen in The Netherlands, and the University of Barcelona in Spain, have developed a method that uses sound to  … Read more

Seeing beyond sight: new computational approaches to understanding cells
December 2018 Newsletter

Since Leeuwenhoek’s first illustrations were published, biologists have strived and struggled to extract understanding from the often noisy and nearly transparent interiors of cells. To better determine and comprehend all of the principles that drive cell behavior, we need to collect and integrate multiple types  … Read more

Combating antimalarial drug resistance
December 2018 Newsletter

Chloroquine (CQ) used to be considered the gold standard in the treatment of malaria caused by the parasite Plasmodium falciparum. However, several strains of P. falciparum are emerging as drug resistant and compromising the current drug treatment. Researchers at the University of São Paulo, Brazil,  … Read more

Developing a Computational Pipeline and Benchmark Datasets for Image-Based Transcriptomics
December 2018 Newsletter

A New Technology Multiplexed image-based transcriptomics is an emerging technology for measuring spatially resolved gene expression in cells and intact tissues at scale. These transcriptomic profiles can be correlated with other measures of cellular structure, function, and localization to obtain a better understanding of cellular  … Read more

Super resolution multi-color TIRF-SIM (Gustafson) images of actin cytoskeletal dynamics in living cells. (A) Cortical actin cytoskeleton in COS-7 (mRuby-LifeAct); (inset) high mag. Bars, 5 and 1 μm. (B) Cortical F-actin (mEmerald-LifeAct) and clathrin-coated pits (mKOrange-clathrin) in INS-1 832/13 cells; (inset) high mag. Bars, 1 μm and 300 nm. (C) Motile actin-derived membrane projections in INS-1 cells from a time-lapse video sequence. (D) 3D kymographs of the movement. (E) Heat color map of 3D kymograph. Bars, 300 nm.
HHMI Janelia’s Advanced Imaging Center: Breaking Barriers
December 2018 Newsletter

Back in the 1980s, I was astounded to be able to see individual microtubules in a squid giant axon the first time I looked through Robert Allen’s video microscope. As a postdoctoral fellow under the mentorship of Shinya Inoue, I observed spindle microtubules in living  … Read more

The cell biologist’s expanding toolbox
December 2018 Newsletter

The cell biologist’s toolbox grows more powerful with each passing year. As cell scientists collaborate with experts in computer science, chemistry, physics, and engineering, new technologies and new methods of using established technologies are added regularly. What can these advanced technologies tell us about cells  … Read more

Bioprinting: Ethical and societal implications

In a recent ASCB Post article in the “What’s it all about?” series, Amanda Haage explains developments in the recent field of 3D printing with biological materials (i.e., bioprinting). Although these methods are still being fine-tuned, the field holds tremendous promise in such areas as  … Read more

What’s it all about? 3D bioprinting

The idea of scientists growing body parts in the lab usually conjures up images of popular science fiction, too farfetched to ever be considered outside of a mad scientist stereotype. In reality, the fields of medical and tissue engineering have made great strides in utilizing  … Read more

Evidence indicates desire for change in undergraduate learning techniques

As an undergraduate psychology major, I had a mandatory course—Biological Basis of Behavior. Previously, I had taken a neurobiology course as an elective and absolutely loved it, so I was looking forward to this course. Unfortunately, the professor teaching the mandatory course never interacted with  … Read more

MBoC to begin publishing reviewer commentary along with articles

To promote transparency in scientific research, the basic research journal of the American Society for Cell Biology, Molecular Biology of the Cell (MBoC), will begin publishing peer review reports along with articles beginning in early 2019. “Publishing peer reviewers’ comments and authors’ responses will encourage  … Read more